Background Noninvasive detection of vulnerable plaque has a significant implication for prevention and treatment of atherosclerotic disea±ses. The aim of this study is to investigate the difference between vulner...Background Noninvasive detection of vulnerable plaque has a significant implication for prevention and treatment of atherosclerotic disea±ses. The aim of this study is to investigate the difference between vulnerable plaques and stable plaques in magnetic resonance （MR） images. Methods Atherosclerosis was induced in twenty male New Zealand white rabbits by high cholesterol diet and balloon injury of the abdominal aorta. After baseline （pre-triggering） MR imaging （MRI） scan, the rabbits underwent pharmaceutical triggering with Russell＇s viper venom and histamine to induce atherothrombosis, followed by another MRI scan 48 hours later （post-triggering）. Rabbits were euthanized to obtain pathological and histological data. The results of MRI were compared with those of pathology and histology. Results MRI showed that abdominal aorta of the rabbits had pathological change of atherosclerosis in different degrees. Seventy-five plaques were analysed, among which 14 had vulnerable thrombi and 61 stable. Thrombosis was identified in 7 of 11 rabbits by post-triggering MRI, the sensitivity and K value of MR in detection of vulnerable plaque was 71% and 0.803 （P 〈0.05）. MRI data significantly correlated with the histopathological data in fibrous cap thickness （t=0.749） plaque area （t=0.853）, lipid core area （r=0.900）. Compared with stable plaques, vulnerable plaques had a significantly thinner fibrous cap （（0.58±0.27） mm vs. （0.95±0.22） mm）, larger lipid core area （（7.56±2.78） mm2 vs. （3.29±1.75） mm2）, and a higher ratio of lipid core area/plaque area （（55±16）% vs. （27±17）%）, but plaque area was comparable in two groups on MRI. The ratio of lipid core area/plaque area was a strong predictor of vulnerable plaques. Conclusion MRI could distinguish vulnerable plaques from stable plaques in a rabbit model of atherothrombosis and may thus be useful as a noninvasive modality for detection of vulnerable plaques in humans.展开更多
基金This study is supported by grants from the National Natural Science Foundation of China （No. 30972810 and No. 81101173）.
文摘Background Noninvasive detection of vulnerable plaque has a significant implication for prevention and treatment of atherosclerotic disea±ses. The aim of this study is to investigate the difference between vulnerable plaques and stable plaques in magnetic resonance （MR） images. Methods Atherosclerosis was induced in twenty male New Zealand white rabbits by high cholesterol diet and balloon injury of the abdominal aorta. After baseline （pre-triggering） MR imaging （MRI） scan, the rabbits underwent pharmaceutical triggering with Russell＇s viper venom and histamine to induce atherothrombosis, followed by another MRI scan 48 hours later （post-triggering）. Rabbits were euthanized to obtain pathological and histological data. The results of MRI were compared with those of pathology and histology. Results MRI showed that abdominal aorta of the rabbits had pathological change of atherosclerosis in different degrees. Seventy-five plaques were analysed, among which 14 had vulnerable thrombi and 61 stable. Thrombosis was identified in 7 of 11 rabbits by post-triggering MRI, the sensitivity and K value of MR in detection of vulnerable plaque was 71% and 0.803 （P 〈0.05）. MRI data significantly correlated with the histopathological data in fibrous cap thickness （t=0.749） plaque area （t=0.853）, lipid core area （r=0.900）. Compared with stable plaques, vulnerable plaques had a significantly thinner fibrous cap （（0.58±0.27） mm vs. （0.95±0.22） mm）, larger lipid core area （（7.56±2.78） mm2 vs. （3.29±1.75） mm2）, and a higher ratio of lipid core area/plaque area （（55±16）% vs. （27±17）%）, but plaque area was comparable in two groups on MRI. The ratio of lipid core area/plaque area was a strong predictor of vulnerable plaques. Conclusion MRI could distinguish vulnerable plaques from stable plaques in a rabbit model of atherothrombosis and may thus be useful as a noninvasive modality for detection of vulnerable plaques in humans.
