高肺血流性肺动脉高压大鼠模型改良

目的:为高肺血流性肺动脉高压的机制研究建立更稳定的实验动物模型。方法:将60只SD大鼠随机分为假手术组、常规分流组、改良分流组,每组20只。假手术组予开腹夹闭腹主动脉5 min;常规分流组和改良分流组均行腹主动脉—下腔静脉穿刺分流术。对穿刺分流术的穿刺口缝合方式进行改良,常规分流组穿刺口予荷包缝合,改良分流组对穿刺口行四点勾线打结缝合。建模11周后,对大鼠腹主动脉—下腔静脉瘘口行B超探查,评估瘘口形成情况;测右心室压力及右心室肥厚指数,评估成模情况;剖腹探查血管肉眼下大体解剖情况。结果:改良分流组大鼠存活率(95%)明显高于常规分流组(65%)(P<0.05);改良分流组瘘口狭窄率(0%)明显低于常规分流组(36.4%)(P<0.05);改良分流组成模率(90%)高于常规分流组(40%)(P<0.05);改良分流组和常规分流组右心室压力和右心室肥厚指数均增高,其中改良分流组较常规分流组右心室压力升高明显(P<0.05)。结论:腹主动脉—下腔静脉穿刺分流术穿刺口缝合方式的改良,使大鼠存活率提高、瘘口狭窄率降低、成模率提高,右心室压力升高更明显,更有利高肺血流性肺动脉高压的机制的研究。

Mineralogical and Geochemical Constraints on the Origin of the Ultramafic Rocks from Wuwamen Ophiolite at the Southern Margin of Middle Tianshan, Xinjiang

Wuwamen ophiolite is located at the southern margin of Middle Tianshan, Xinjiang Province. In this paper, petrology, mineralogy and geochemistry of the ultramafic rocks from Wuwamen ophiolite were studied to constrain their origin and tectonic setting. The studies will be helpful in interpreting the evolution process of the South Tianshan Ocean.

Petrological, Geochemical and the Origin of the Cuobuzha Peridotite in the Western Yarlung Zangbo Suture Zone

Ophiolites are fragments of ancient oceanic lithosphere emplaced onto continental margins, accretionary prisms, or island arcs during plate collisions （Dilek and Fumes, 2011）. The well-preserved ophiolitic sequence provides important information on melt extraction, melting,