Four new prenylflavonoid glycosides,namely koreanoside H-K(1-4),together with eleven known ones(5-15)were isolated from the leaves of Epimedium koreanum Nakai.Their structures were elucidated by ID NMR,2D NMR,HR-ESI-M...Four new prenylflavonoid glycosides,namely koreanoside H-K(1-4),together with eleven known ones(5-15)were isolated from the leaves of Epimedium koreanum Nakai.Their structures were elucidated by ID NMR,2D NMR,HR-ESI-MS,IR and UV.The identification of the sugar moieties was carried out by means of acid hydrolysis and HPLC analysis of their derivatives.It is worth noting that compound 3 and compound 4 were elucidated to contain fucose and quinovose moieties,which were two extremely rare sugar units from the genus Epimedium.The anti-pulmonary fibrosis activity of the new compounds was evaluated using A549 cell line.Compounds 1,2 and 4 showed significant anti-pulmonary fibrosis activities.展开更多
基金supported by the National Natural Science Foundation of China(Nos.81673548 and U20A20407)Liaoning Revitalization Talents Program(No.XLYC1902119).
文摘Four new prenylflavonoid glycosides,namely koreanoside H-K(1-4),together with eleven known ones(5-15)were isolated from the leaves of Epimedium koreanum Nakai.Their structures were elucidated by ID NMR,2D NMR,HR-ESI-MS,IR and UV.The identification of the sugar moieties was carried out by means of acid hydrolysis and HPLC analysis of their derivatives.It is worth noting that compound 3 and compound 4 were elucidated to contain fucose and quinovose moieties,which were two extremely rare sugar units from the genus Epimedium.The anti-pulmonary fibrosis activity of the new compounds was evaluated using A549 cell line.Compounds 1,2 and 4 showed significant anti-pulmonary fibrosis activities.
