[目的]本文对国内外已经发表的自然语言处理领域有关文本嵌入的研究进行较深入的分析和对比,详细描述文本嵌入的知识结构和发展脉络,以及针对不同领域、不同数据集的模型改进方法,讨论流行的嵌入模型,比较每个模型在文本嵌入中的优缺点...[目的]本文对国内外已经发表的自然语言处理领域有关文本嵌入的研究进行较深入的分析和对比,详细描述文本嵌入的知识结构和发展脉络,以及针对不同领域、不同数据集的模型改进方法,讨论流行的嵌入模型,比较每个模型在文本嵌入中的优缺点,同时指出文本嵌入所面临的挑战,提出可能的解决方案。[方法]检索Web of Science数据库、CNKI数据库和万方数据,获取国内外文本嵌入研究的相关文献,运用内容分析法对文献做系统梳理分析,对这些文献中利用的文本嵌入技术以及改进方案、建模思想、生成过程等方面进行对比与分析。[结果]经过去重和合并,保留内容最相关的61篇文献。文本嵌入方法可以归纳为三类:基于频率的文本嵌入、基于神经网络的文本嵌入和基于主题建模的文本嵌入。针对语料库的规模大小、多义词嵌入、通用嵌入的域适应等文本嵌入所面临的挑战,从被调查的研究文章中提出了可能的解决方案。展开更多
为了探究胶合板在室内开放环境下VOCs(挥发性有机化合物)释放的规律,选取18 mm厚的三聚氰胺浸渍纸饰面胶合板(MI)、PVC饰面胶合板(PVC)、水性漆饰面胶合板(WP)以及胶合板素板(UP)作为实验材料进行换气率为1次/h的循环试验,利用15 L VOC...为了探究胶合板在室内开放环境下VOCs(挥发性有机化合物)释放的规律,选取18 mm厚的三聚氰胺浸渍纸饰面胶合板(MI)、PVC饰面胶合板(PVC)、水性漆饰面胶合板(WP)以及胶合板素板(UP)作为实验材料进行换气率为1次/h的循环试验,利用15 L VOCs动态采样舱和气相色谱-质谱联用仪,对4种胶合板在实验的第1、3、7、14、21、28 d进行采样分析,进而得到VOCs的释放浓度与组分特征。结果表明:4种胶合板的VOCs浓度在释放平衡期受到装载率的影响要小于释放初期;MI释放初期在4种装载率条件下VOCs浓度差最大;装载率对于WP释放的VOCs浓度影响最小。饰面材料可以有效地阻隔板材内部芳香烃等VOCs向外散发。4种胶合板释放的VOCs浓度随装载率的增大呈现非线性上升趋势。占比大、浓度高的芳香烃类化合物随着装载率的变化呈现不同的增长趋势,醛类物质浓度较低,但总体上也随着装载率的增大而增大。实验测得4种胶合板释放的VOCs浓度以及醛类化合物的浓度均不超过优等品释放限值规定,本次研究为进一步探索胶合板优等品的最大装载率限量提供理论基础,也为室内装修胶合板的科学选材用材提供参考。展开更多
Dihydroartemisinin(DHA)is the primary active metabolite of Artemisia annua,which is used to treat malaria worldwide.DHA can activate autophagy to remove the harmful or useless su bstances from eukaryotic cells,and mai...Dihydroartemisinin(DHA)is the primary active metabolite of Artemisia annua,which is used to treat malaria worldwide.DHA can activate autophagy to remove the harmful or useless su bstances from eukaryotic cells,and maintain the cell viability through autolysosomal degradation system.Autophagy activation and autophagy flux are playing an important neuroprotective role in the CNS,as they accelerate the removal of toxic protein aggregates intracellularly and extracellularly to prevent Alzheimer's disease(AD).展开更多
Autophagy has been reported to play a dual"double-edged sword"role in the occurrence and development of Alzheimer's disease(AD).To assess the relationship between AD and autophagy,the dynamic changes of ...Autophagy has been reported to play a dual"double-edged sword"role in the occurrence and development of Alzheimer's disease(AD).To assess the relationship between AD and autophagy,the dynamic changes of autophagic flux in the brain of postmortem AD patients,animal models and cell models were studied.The results showed that in AD patients,LC3 was accumulated in large amount,but the expression of Lamp1 and CTSB decreased,and the co-expression of LC3 and CTSB decreased.In the brain of APP/PS1 double transgenic mice,autophagosomes(APs)and autolysosomes(ALs)accumulation occur with the deposition of senile plaques(SPs),and the levels of lysosomal markers CTSB and Lamp1 protein decreased significantly.In the brain of APP/PS1/LC3 triple transgenic mice,the number of APs increased with the age of mice,but the number of ALs did not increase accordingly.展开更多
OBJECTIVE:To assess the effectiveness and safety of traditional Chinese medical therapy for cancer-related fatigue.METHODS:We systematically searched eight electronic databases up to June 2017 for randomized clinical ...OBJECTIVE:To assess the effectiveness and safety of traditional Chinese medical therapy for cancer-related fatigue.METHODS:We systematically searched eight electronic databases up to June 2017 for randomized clinical trials of traditional Chinese medical therapy for cancer-related fatigue.Two authors independently extracted data and assessed the risk bias of the included trials using the Cochrane Handbook.Data were analyzed by Rev Man 5.2 software.RESULTS:A total of 23 trials involving 1832 participants identified with cancer-related fatigue were included.Twenty trials reported a beneficial effect of traditional Chinese medical therapy on cancer-related fatigue.On pooling the data from Chinese herbal medicine therapy and acupuncture or moxibustion therapy,respectively,significant differences were found between experimental groups and control groups.Fatigue improvement rates showed significant differences between traditional Chinese medical therapy and control groups[odds ratio(OR),7.62;95%confidence interval(CI),3.75-15.49;P<0.00001;and OR,3.78;95%CI,2.29-6.23;P<0.00001).Fatigue change scores also showed significant differences between the two groups(mean difference,-0.91;95%CI,-1.16 to-0.65;P<0.00001).Eleven trials demonstrated that traditional Chinese medical therapy improved the quality of life of cancer patients.No severe adverse effects occurred in traditional Chinese medical therapy groups.CONCLUSION:Meta-analysis showed that Chinese medical therapy seems to be effective and safe in the treatment of cancer-related fatigue.展开更多
文摘[目的]本文对国内外已经发表的自然语言处理领域有关文本嵌入的研究进行较深入的分析和对比,详细描述文本嵌入的知识结构和发展脉络,以及针对不同领域、不同数据集的模型改进方法,讨论流行的嵌入模型,比较每个模型在文本嵌入中的优缺点,同时指出文本嵌入所面临的挑战,提出可能的解决方案。[方法]检索Web of Science数据库、CNKI数据库和万方数据,获取国内外文本嵌入研究的相关文献,运用内容分析法对文献做系统梳理分析,对这些文献中利用的文本嵌入技术以及改进方案、建模思想、生成过程等方面进行对比与分析。[结果]经过去重和合并,保留内容最相关的61篇文献。文本嵌入方法可以归纳为三类:基于频率的文本嵌入、基于神经网络的文本嵌入和基于主题建模的文本嵌入。针对语料库的规模大小、多义词嵌入、通用嵌入的域适应等文本嵌入所面临的挑战,从被调查的研究文章中提出了可能的解决方案。
文摘为了探究胶合板在室内开放环境下VOCs(挥发性有机化合物)释放的规律,选取18 mm厚的三聚氰胺浸渍纸饰面胶合板(MI)、PVC饰面胶合板(PVC)、水性漆饰面胶合板(WP)以及胶合板素板(UP)作为实验材料进行换气率为1次/h的循环试验,利用15 L VOCs动态采样舱和气相色谱-质谱联用仪,对4种胶合板在实验的第1、3、7、14、21、28 d进行采样分析,进而得到VOCs的释放浓度与组分特征。结果表明:4种胶合板的VOCs浓度在释放平衡期受到装载率的影响要小于释放初期;MI释放初期在4种装载率条件下VOCs浓度差最大;装载率对于WP释放的VOCs浓度影响最小。饰面材料可以有效地阻隔板材内部芳香烃等VOCs向外散发。4种胶合板释放的VOCs浓度随装载率的增大呈现非线性上升趋势。占比大、浓度高的芳香烃类化合物随着装载率的变化呈现不同的增长趋势,醛类物质浓度较低,但总体上也随着装载率的增大而增大。实验测得4种胶合板释放的VOCs浓度以及醛类化合物的浓度均不超过优等品释放限值规定,本次研究为进一步探索胶合板优等品的最大装载率限量提供理论基础,也为室内装修胶合板的科学选材用材提供参考。
文摘Dihydroartemisinin(DHA)is the primary active metabolite of Artemisia annua,which is used to treat malaria worldwide.DHA can activate autophagy to remove the harmful or useless su bstances from eukaryotic cells,and maintain the cell viability through autolysosomal degradation system.Autophagy activation and autophagy flux are playing an important neuroprotective role in the CNS,as they accelerate the removal of toxic protein aggregates intracellularly and extracellularly to prevent Alzheimer's disease(AD).
文摘Autophagy has been reported to play a dual"double-edged sword"role in the occurrence and development of Alzheimer's disease(AD).To assess the relationship between AD and autophagy,the dynamic changes of autophagic flux in the brain of postmortem AD patients,animal models and cell models were studied.The results showed that in AD patients,LC3 was accumulated in large amount,but the expression of Lamp1 and CTSB decreased,and the co-expression of LC3 and CTSB decreased.In the brain of APP/PS1 double transgenic mice,autophagosomes(APs)and autolysosomes(ALs)accumulation occur with the deposition of senile plaques(SPs),and the levels of lysosomal markers CTSB and Lamp1 protein decreased significantly.In the brain of APP/PS1/LC3 triple transgenic mice,the number of APs increased with the age of mice,but the number of ALs did not increase accordingly.
基金Supported by Grants from the Natural Science Foundation of China(No.81903991,No.81974543)the Natural Science Foundation of Guangdong Province(No.2017A030310326,No.2019A1515011362)+3 种基金the Guangzhou science and technology plan project(No.201804010149,No.202002030155)the Chinese medicine science and technology research project of Guangdong Provincial Hospital of Chinese Medicine(No.YN2019MJ09)the Major Research Projects in First-class Disciplines of Guangzhou University of Chinese Medicine(No.A1260619111001)the Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome(No.ZH2020KF03)
文摘OBJECTIVE:To assess the effectiveness and safety of traditional Chinese medical therapy for cancer-related fatigue.METHODS:We systematically searched eight electronic databases up to June 2017 for randomized clinical trials of traditional Chinese medical therapy for cancer-related fatigue.Two authors independently extracted data and assessed the risk bias of the included trials using the Cochrane Handbook.Data were analyzed by Rev Man 5.2 software.RESULTS:A total of 23 trials involving 1832 participants identified with cancer-related fatigue were included.Twenty trials reported a beneficial effect of traditional Chinese medical therapy on cancer-related fatigue.On pooling the data from Chinese herbal medicine therapy and acupuncture or moxibustion therapy,respectively,significant differences were found between experimental groups and control groups.Fatigue improvement rates showed significant differences between traditional Chinese medical therapy and control groups[odds ratio(OR),7.62;95%confidence interval(CI),3.75-15.49;P<0.00001;and OR,3.78;95%CI,2.29-6.23;P<0.00001).Fatigue change scores also showed significant differences between the two groups(mean difference,-0.91;95%CI,-1.16 to-0.65;P<0.00001).Eleven trials demonstrated that traditional Chinese medical therapy improved the quality of life of cancer patients.No severe adverse effects occurred in traditional Chinese medical therapy groups.CONCLUSION:Meta-analysis showed that Chinese medical therapy seems to be effective and safe in the treatment of cancer-related fatigue.
