Although bacterial persistence was first observed in 1944,its underlying mechanism is just beginning to be understood and many fundamental questions remain.In this review,we summarize studies in order to chart the ful...Although bacterial persistence was first observed in 1944,its underlying mechanism is just beginning to be understood and many fundamental questions remain.In this review,we summarize studies in order to chart the full map of bacterial persistence.Because persistence significantly contributes to disease recalcitrance,we also elucidate the probable relationships between bacterial persistence and prolonged chronic infections,with some comments on future research directions and therapeutic strategies.展开更多
基金supported by the National Natural Science Foundation of China(31370847)the Recruitment Program of Global Youth Experts
文摘Although bacterial persistence was first observed in 1944,its underlying mechanism is just beginning to be understood and many fundamental questions remain.In this review,we summarize studies in order to chart the full map of bacterial persistence.Because persistence significantly contributes to disease recalcitrance,we also elucidate the probable relationships between bacterial persistence and prolonged chronic infections,with some comments on future research directions and therapeutic strategies.
