目的:分析小柴胡胶囊在免疫球蛋白A肾病(Immunoglobulin A Nephropathy,IgAN)患者中的应用效果。方法:选取2018年5月-2019年8月笔者所在单位收治的IgAN患者76例作为研究对象,根据不同治疗措施分成甲组和乙组,两组各38例。甲组患者接受...目的:分析小柴胡胶囊在免疫球蛋白A肾病(Immunoglobulin A Nephropathy,IgAN)患者中的应用效果。方法:选取2018年5月-2019年8月笔者所在单位收治的IgAN患者76例作为研究对象,根据不同治疗措施分成甲组和乙组,两组各38例。甲组患者接受常规治疗,乙组患者在甲组基础上应用小柴胡胶囊。比较两组临床疗效、血尿相关指标。结果:甲组患者临床总有效率低于乙组,P<0.05。治疗前,两组患者尿红细胞、血肌酐、24 h尿蛋白定量等临床指标水平相比,P>0.05;治疗后,两组上述临床指标水平相比,P<0.001。结论:小柴胡胶囊治疗IgAN的疗效可靠,明显能改善患者血肌酐等指标。展开更多
Halogen substituted β-amino acids, D,L-3-amino-3-（4-fluoro）phenylpropionic acid（D,L-HL1, 1） and D,L-3-amino-3-（4-bromo）phenylpropionic acid（D,L-HL2, 2）, as well as their Cu（II） coordination complexes [Cu（L...Halogen substituted β-amino acids, D,L-3-amino-3-（4-fluoro）phenylpropionic acid（D,L-HL1, 1） and D,L-3-amino-3-（4-bromo）phenylpropionic acid（D,L-HL2, 2）, as well as their Cu（II） coordination complexes [Cu（L1）2（CH3OH）2].2CH3OH（3） and [Cu（L2）2（CH3OH）2]-2CHaOH（4） were investigated and their single crystal structures were discussed in details. Supramolecular helical chains were found in β-amino acids 1 and 2 while there was no helix in their coordination complexes 3 and 4. The formation of supramolecular helixes could be due to the hydrogen bonds between terminal -NH3＋ and adjacent -COO- in β-amino acids 1 and 2. While, this kind of hydrogen bonds could not be observed in their Cu（II） coordination complexes 3 and 4, in which central-symmetrical dimers could be formed via coplanar coordinated bonds（N-Cu-O） between -NH2 and -COO-.展开更多
文摘目的:分析小柴胡胶囊在免疫球蛋白A肾病(Immunoglobulin A Nephropathy,IgAN)患者中的应用效果。方法:选取2018年5月-2019年8月笔者所在单位收治的IgAN患者76例作为研究对象,根据不同治疗措施分成甲组和乙组,两组各38例。甲组患者接受常规治疗,乙组患者在甲组基础上应用小柴胡胶囊。比较两组临床疗效、血尿相关指标。结果:甲组患者临床总有效率低于乙组,P<0.05。治疗前,两组患者尿红细胞、血肌酐、24 h尿蛋白定量等临床指标水平相比,P>0.05;治疗后,两组上述临床指标水平相比,P<0.001。结论:小柴胡胶囊治疗IgAN的疗效可靠,明显能改善患者血肌酐等指标。
基金Supported by the National Natural Science Foundation of China（Nos.21071018, 21271026）.
文摘Halogen substituted β-amino acids, D,L-3-amino-3-（4-fluoro）phenylpropionic acid（D,L-HL1, 1） and D,L-3-amino-3-（4-bromo）phenylpropionic acid（D,L-HL2, 2）, as well as their Cu（II） coordination complexes [Cu（L1）2（CH3OH）2].2CH3OH（3） and [Cu（L2）2（CH3OH）2]-2CHaOH（4） were investigated and their single crystal structures were discussed in details. Supramolecular helical chains were found in β-amino acids 1 and 2 while there was no helix in their coordination complexes 3 and 4. The formation of supramolecular helixes could be due to the hydrogen bonds between terminal -NH3＋ and adjacent -COO- in β-amino acids 1 and 2. While, this kind of hydrogen bonds could not be observed in their Cu（II） coordination complexes 3 and 4, in which central-symmetrical dimers could be formed via coplanar coordinated bonds（N-Cu-O） between -NH2 and -COO-.
