构建管流式冲刷腐蚀实验装置研究γ预辐照对铍在一号电火花加工油(EDM-1)中腐蚀性能的影响,研究铍试样质量变化,进行表面形貌及成分分析.结果表明,铍在EDM-1管流冲刷条件下受冲刷腐蚀和化学腐蚀的共同作用,前者主要受试样表面形态影响,...构建管流式冲刷腐蚀实验装置研究γ预辐照对铍在一号电火花加工油(EDM-1)中腐蚀性能的影响,研究铍试样质量变化,进行表面形貌及成分分析.结果表明,铍在EDM-1管流冲刷条件下受冲刷腐蚀和化学腐蚀的共同作用,前者主要受试样表面形态影响,后者主要受γ预辐照剂量、杂质元素、EDM-1中含硫有机物等的影响.辐照前后,试样质量均呈现先减小、后增大、再减小趋势,腐蚀速率基本随辐照剂量的升高而增大.γ预辐照促进了铍试样在EDM-1中点蚀核和蚀孔的产生,腐蚀2880 h后,未接受预辐照试样仅产生较为明显点蚀核,而接受200和100 k Gy预辐照试样中的部分点蚀核发展成为蚀孔,前者直径约为后者2倍.点蚀核和蚀孔区域出现Al、Si、Fe、Cr、Ti等杂质元素及S元素,杂质元素为诱导产生点蚀的重要因素,含S有机物发生化学反应分别生成物理吸附和化学吸附于蚀孔内部的SO2和SOx,促进蚀孔的形成及扩展.展开更多
Background A bioactive compound from Paecilomyces tenuipes （BCPT） has an inhibitory effect on monoamine oxidase A （MAO-A） and monoamine oxidase B （MAO-B） in vitro and in vivo, which indicates BCPT may be a poten...Background A bioactive compound from Paecilomyces tenuipes （BCPT） has an inhibitory effect on monoamine oxidase A （MAO-A） and monoamine oxidase B （MAO-B） in vitro and in vivo, which indicates BCPT may be a potential antidepressant. In this study we aimed to study the antidepressant effects of BCPT in the chronic unpredictable stress （CUS） model in rats and explore underlying mechanisms in the hypothalamic-pituitary-adrenal （HPA） axis. Methods The antidepressant effects of BCPT were studied in the chronic unpredictable stress model in rats. Animals were housed isolated, except the control group. Rats were exposed daily to different random stressors from day 1 to 21. Awarding response was detected by calculating the 24-hour consumption of sucrose water. Cortisol （CORT） and adrenocorticotropic hormone （ATCH） contents in serum and arginine vasopressin （AVP） contents in the pituitary body were detected by radio immunoassays. Total RNA of hippocampus or hypothalamus was extracted and subjected to reverse transcription-polymerase chain reaction （RT-PCR） for the measurement of corticotrophin releasing hormone （CRH） mRNA or mineralocorticoid receptor （MR） mRNA and glucocorticoid receptor （GR） mRNA levels. Statistical analyses were performed using one way analysis of variance （ANOVA） followed by Student-Newman-Keuls （SNK） test. Results Chronic unpredictable stress resulted in reduction of sensitivity to reward and abnormality in the HPA axis in the animal model. BCPT improved the reward reaction as measured by increasing sucrose consumption, remarkably reduced serum CORT and ACTH levels and the AVP content in the pituitary body in the CUS-treated rats, decreased the expression of CRH mRNA, enhanced the expression of hippocampus MR mRNA, GR mRNA and decreased the ratio of MR/GR. Conclusions BCPT has potentially antidepressant-like activity and normalized the HPA axis hyperactivity in a CUS model of depression in rats. This may be an important mechanism of its antidepressant effect.展开更多
Tibetan medicinal plants have been used for more than 2 000 years. In order to find their differences in antioxidant activity, total phenolics and total flavonoids between "hot-nature" and "cold-nature&...Tibetan medicinal plants have been used for more than 2 000 years. In order to find their differences in antioxidant activity, total phenolics and total flavonoids between "hot-nature" and "cold-nature" herbs, we investigated the antioxidant activities of 40 Tibetan herbs from Qinghai plateau, with 20 herbs in cold-nature and 20 herbs in hot-nature. Antioxidant capacities were evaluated by the following methods: scavenging ABTS?+(2, 2′azinobis-(3-ethylbenz-thiazoline-6-sulfonic acid), scavenging O2?-, and Ferric-reducing antioxidant power(FRAP). The effects on inhibition of mitochondrion lipid peroxidation were determined by measuring the formation of TBARS(Thiobarbituric acid reactive substrates). Total phenolics and flavonoids were estimated by Folin-Ciocalteu and Na NO2-Al(NO3)3-Na OH colorimetric methods. Interestingly, the cold-nature herbs displayed higher antioxidant activities than the hot-nature ones, corresponding to nearly three-fold higher total phenolic contents in the cold-nature herbs. Moreover, the antioxidant activities correlated linearly with the levels of total phenolics for both cold-nature and hot-nature herbs, but only with the levels of total flavonoids for the hot-nature herbs. The results suggested that the phenolic compounds, but not the flavonoids, play the major role in antioxidant capacities of the cold-nature herbs. These findings could shed new lights on the study the theory of Tibetan medicine.展开更多
Objective: To observe the clinical efficacy of acupuncture for perimenopausal syndrome. Methods: A total of 40 perimenopausal syndrome cases who met the inclusion criteria were randomized into an observation group and...Objective: To observe the clinical efficacy of acupuncture for perimenopausal syndrome. Methods: A total of 40 perimenopausal syndrome cases who met the inclusion criteria were randomized into an observation group and a control group, 20 in each group. Acupuncture combining with ginger-partitioned moxibustion was used in the observation group, whereas acupuncture was used in the control group. Modified Kupperman Index (KI) was evaluated respectively before and after treatment. In addition, the clinical efficacies in the two groups were compared. Results: The total effective rate in the observation group was higher than that in the control group (P<0.05). After treatment, KI in both groups were significantly reduced (P<0.01) and there was a statistical difference between the two groups (P<0.01). Conclusion: Acupuncture combining with ginger-partitioned moxibustion could obtain a higher total effective rate for perimenopausal syndrome than acupuncture alone. Furthermore, it was also superior to acupuncture alone in improving hot flushes, insomnia, melancholia and arthralgia or myalgia.展开更多
基金supported by grants from the National Natural Science Foundation of China (No. 31271273, 31300975)Shanghai Natural Science Foundation (No. 18ZR1437100)Shanghai Key Laboratory of Human Movement Development and Protection (Shanghai University of Sport) (No. 11DZ2261100)
文摘构建管流式冲刷腐蚀实验装置研究γ预辐照对铍在一号电火花加工油(EDM-1)中腐蚀性能的影响,研究铍试样质量变化,进行表面形貌及成分分析.结果表明,铍在EDM-1管流冲刷条件下受冲刷腐蚀和化学腐蚀的共同作用,前者主要受试样表面形态影响,后者主要受γ预辐照剂量、杂质元素、EDM-1中含硫有机物等的影响.辐照前后,试样质量均呈现先减小、后增大、再减小趋势,腐蚀速率基本随辐照剂量的升高而增大.γ预辐照促进了铍试样在EDM-1中点蚀核和蚀孔的产生,腐蚀2880 h后,未接受预辐照试样仅产生较为明显点蚀核,而接受200和100 k Gy预辐照试样中的部分点蚀核发展成为蚀孔,前者直径约为后者2倍.点蚀核和蚀孔区域出现Al、Si、Fe、Cr、Ti等杂质元素及S元素,杂质元素为诱导产生点蚀的重要因素,含S有机物发生化学反应分别生成物理吸附和化学吸附于蚀孔内部的SO2和SOx,促进蚀孔的形成及扩展.
基金the grants from the Anhui Education Department(No.2004KJ194ZD)the Anhui Science & Technology Department (No.04023048)
文摘Background A bioactive compound from Paecilomyces tenuipes （BCPT） has an inhibitory effect on monoamine oxidase A （MAO-A） and monoamine oxidase B （MAO-B） in vitro and in vivo, which indicates BCPT may be a potential antidepressant. In this study we aimed to study the antidepressant effects of BCPT in the chronic unpredictable stress （CUS） model in rats and explore underlying mechanisms in the hypothalamic-pituitary-adrenal （HPA） axis. Methods The antidepressant effects of BCPT were studied in the chronic unpredictable stress model in rats. Animals were housed isolated, except the control group. Rats were exposed daily to different random stressors from day 1 to 21. Awarding response was detected by calculating the 24-hour consumption of sucrose water. Cortisol （CORT） and adrenocorticotropic hormone （ATCH） contents in serum and arginine vasopressin （AVP） contents in the pituitary body were detected by radio immunoassays. Total RNA of hippocampus or hypothalamus was extracted and subjected to reverse transcription-polymerase chain reaction （RT-PCR） for the measurement of corticotrophin releasing hormone （CRH） mRNA or mineralocorticoid receptor （MR） mRNA and glucocorticoid receptor （GR） mRNA levels. Statistical analyses were performed using one way analysis of variance （ANOVA） followed by Student-Newman-Keuls （SNK） test. Results Chronic unpredictable stress resulted in reduction of sensitivity to reward and abnormality in the HPA axis in the animal model. BCPT improved the reward reaction as measured by increasing sucrose consumption, remarkably reduced serum CORT and ACTH levels and the AVP content in the pituitary body in the CUS-treated rats, decreased the expression of CRH mRNA, enhanced the expression of hippocampus MR mRNA, GR mRNA and decreased the ratio of MR/GR. Conclusions BCPT has potentially antidepressant-like activity and normalized the HPA axis hyperactivity in a CUS model of depression in rats. This may be an important mechanism of its antidepressant effect.
基金supported by Gansu Provincial Natural Science Foundation(No.1208RJYA014)Chinese Postdoctoral Science Foundation(No.2009-0460744)+1 种基金Fundamental Research Funds for the Central Universities(No.lzujbky-2014-151)the Natural Science Foundation of China(No.21302079)
文摘Tibetan medicinal plants have been used for more than 2 000 years. In order to find their differences in antioxidant activity, total phenolics and total flavonoids between "hot-nature" and "cold-nature" herbs, we investigated the antioxidant activities of 40 Tibetan herbs from Qinghai plateau, with 20 herbs in cold-nature and 20 herbs in hot-nature. Antioxidant capacities were evaluated by the following methods: scavenging ABTS?+(2, 2′azinobis-(3-ethylbenz-thiazoline-6-sulfonic acid), scavenging O2?-, and Ferric-reducing antioxidant power(FRAP). The effects on inhibition of mitochondrion lipid peroxidation were determined by measuring the formation of TBARS(Thiobarbituric acid reactive substrates). Total phenolics and flavonoids were estimated by Folin-Ciocalteu and Na NO2-Al(NO3)3-Na OH colorimetric methods. Interestingly, the cold-nature herbs displayed higher antioxidant activities than the hot-nature ones, corresponding to nearly three-fold higher total phenolic contents in the cold-nature herbs. Moreover, the antioxidant activities correlated linearly with the levels of total phenolics for both cold-nature and hot-nature herbs, but only with the levels of total flavonoids for the hot-nature herbs. The results suggested that the phenolic compounds, but not the flavonoids, play the major role in antioxidant capacities of the cold-nature herbs. These findings could shed new lights on the study the theory of Tibetan medicine.
基金supported by Zhejiang University of Traditional Chinese Medicine and Hangzhou Red Cross Hospital
文摘Objective: To observe the clinical efficacy of acupuncture for perimenopausal syndrome. Methods: A total of 40 perimenopausal syndrome cases who met the inclusion criteria were randomized into an observation group and a control group, 20 in each group. Acupuncture combining with ginger-partitioned moxibustion was used in the observation group, whereas acupuncture was used in the control group. Modified Kupperman Index (KI) was evaluated respectively before and after treatment. In addition, the clinical efficacies in the two groups were compared. Results: The total effective rate in the observation group was higher than that in the control group (P<0.05). After treatment, KI in both groups were significantly reduced (P<0.01) and there was a statistical difference between the two groups (P<0.01). Conclusion: Acupuncture combining with ginger-partitioned moxibustion could obtain a higher total effective rate for perimenopausal syndrome than acupuncture alone. Furthermore, it was also superior to acupuncture alone in improving hot flushes, insomnia, melancholia and arthralgia or myalgia.
