目的探讨内镜下胃食管阀瓣形态与胃食管反流病(gastroesophageal reflux disease,GERD)的相关性,为临床早期诊疗提供依据。方法选取疑似GERD病人160例作为研究对象,其中确诊GERD病人99例,设为GERD组;非GERD病人61例,设为正常组。均进行...目的探讨内镜下胃食管阀瓣形态与胃食管反流病(gastroesophageal reflux disease,GERD)的相关性,为临床早期诊疗提供依据。方法选取疑似GERD病人160例作为研究对象,其中确诊GERD病人99例,设为GERD组;非GERD病人61例,设为正常组。均进行胃食管内镜、食管24 h PH-阻抗监测、食管高分辨测压等,对比两组相关检测指标等,分析GERD与内镜下胃食管阀瓣形态的关系。结果正常组病人年龄、BMI指数、胃食管阀瓣分级、吸烟史、焦虑与抑郁、反流性食管炎发生率均低于GERD组,差异有统计学意义(P<0.05)。正常组病人24 h pH-阻抗检测各项指标评分均低于GERD组,而食管压力测定各指标优于GERD组,差异有统计学意义(P<0.05)。经Logistic回归分析,年龄≥60岁、BMI指数≥24.0 kg/m^(2)、吸烟史、胃食管阀瓣分级(Ⅲ+Ⅳ级)、焦虑、抑郁、Demeester评分、LES压力、UES压力是影响GERD的独立危险因素。内镜下胃食管阀瓣形态(Ⅲ+Ⅳ)AUC值为0.657,诊断敏感度80.81%、特异度为84.85%,食管压力测定AUC值为0.579,敏感度75.76%、特异度80.81%,24 h pH-阻抗AUC值为0.720,诊断敏感度为83.84%、特异度85.86%。结论胃食管阀瓣与GERD发生有明显关系,通过观察胃食管阀瓣内镜下形态,可有效预测GERD的发生。吸烟、肥胖、焦虑抑郁情绪等是影响胃食管阀瓣的危险因素。展开更多
Objective: In view of the extensive bone damage in rheumatoid arthritis, we used a commonly utilized animal model to detect behavioral changes in pain-related and the bone damage during the early disease, and to explo...Objective: In view of the extensive bone damage in rheumatoid arthritis, we used a commonly utilized animal model to detect behavioral changes in pain-related and the bone damage during the early disease, and to explore the correlation between bone damage and pain-related behavioral changes. Methods: Arthritis were induced in Sprague-Dawley (SD) male rats by injecting complete Freund's adjuvant (CFA) into the tails. Pain-related behavior changes were studied using the Hargreaves, VonFrey, and acetone tests on the 0, 7, 14, day and 28 day after CFA injection. The rats were sacrificed according the same schedule. The bone damage of the right proximal tibia was studied by microCT scan and bone histological slices. Results: Animals developed soft tissue inflammation and polyarthritis on 7 days after CFA injection, and arthritic score proved obvious arthritis were established within the study period. Mechanical hyperalgesia and cold allodynia were present in the affected hind paw from the 7 day through the 28 day, but the heat hyperalgesia and the mechanical allodynia lasted a short time after CFA injection. Trabecular bone number (Tb.N), Tissue Mineral Content (TMC) and Bone Volume to Tissue Volume (BV/TV) in the proximal tibia by microCT scan were also reduced after induction, especial 14 days after CFA injection. The bone histological slices showed the trabecular bone and proteoglycan diminished, the bone damage severity scores became more severely on the 7 day after CFA injection. Using analysis of covariance, these changes had statistical significance compared with baseline. By linear regression analysis demonstrated mechanical hyperalgesia and cold allodynia correlated well with arthritic score, bone damage parameters and bone damage severity scores. Conclusion: Adjuvant-induced arthritis (AA) were observed after CFA injection and lasted within the later experimental period. Pain-related behavioral changes were observed in the early time of AA. Bone damage was also occurred with arthritis development. Pain-related behavioral change correlated well with arthritic score and bone damage parameters.展开更多
文摘目的探讨内镜下胃食管阀瓣形态与胃食管反流病(gastroesophageal reflux disease,GERD)的相关性,为临床早期诊疗提供依据。方法选取疑似GERD病人160例作为研究对象,其中确诊GERD病人99例,设为GERD组;非GERD病人61例,设为正常组。均进行胃食管内镜、食管24 h PH-阻抗监测、食管高分辨测压等,对比两组相关检测指标等,分析GERD与内镜下胃食管阀瓣形态的关系。结果正常组病人年龄、BMI指数、胃食管阀瓣分级、吸烟史、焦虑与抑郁、反流性食管炎发生率均低于GERD组,差异有统计学意义(P<0.05)。正常组病人24 h pH-阻抗检测各项指标评分均低于GERD组,而食管压力测定各指标优于GERD组,差异有统计学意义(P<0.05)。经Logistic回归分析,年龄≥60岁、BMI指数≥24.0 kg/m^(2)、吸烟史、胃食管阀瓣分级(Ⅲ+Ⅳ级)、焦虑、抑郁、Demeester评分、LES压力、UES压力是影响GERD的独立危险因素。内镜下胃食管阀瓣形态(Ⅲ+Ⅳ)AUC值为0.657,诊断敏感度80.81%、特异度为84.85%,食管压力测定AUC值为0.579,敏感度75.76%、特异度80.81%,24 h pH-阻抗AUC值为0.720,诊断敏感度为83.84%、特异度85.86%。结论胃食管阀瓣与GERD发生有明显关系,通过观察胃食管阀瓣内镜下形态,可有效预测GERD的发生。吸烟、肥胖、焦虑抑郁情绪等是影响胃食管阀瓣的危险因素。
文摘Objective: In view of the extensive bone damage in rheumatoid arthritis, we used a commonly utilized animal model to detect behavioral changes in pain-related and the bone damage during the early disease, and to explore the correlation between bone damage and pain-related behavioral changes. Methods: Arthritis were induced in Sprague-Dawley (SD) male rats by injecting complete Freund's adjuvant (CFA) into the tails. Pain-related behavior changes were studied using the Hargreaves, VonFrey, and acetone tests on the 0, 7, 14, day and 28 day after CFA injection. The rats were sacrificed according the same schedule. The bone damage of the right proximal tibia was studied by microCT scan and bone histological slices. Results: Animals developed soft tissue inflammation and polyarthritis on 7 days after CFA injection, and arthritic score proved obvious arthritis were established within the study period. Mechanical hyperalgesia and cold allodynia were present in the affected hind paw from the 7 day through the 28 day, but the heat hyperalgesia and the mechanical allodynia lasted a short time after CFA injection. Trabecular bone number (Tb.N), Tissue Mineral Content (TMC) and Bone Volume to Tissue Volume (BV/TV) in the proximal tibia by microCT scan were also reduced after induction, especial 14 days after CFA injection. The bone histological slices showed the trabecular bone and proteoglycan diminished, the bone damage severity scores became more severely on the 7 day after CFA injection. Using analysis of covariance, these changes had statistical significance compared with baseline. By linear regression analysis demonstrated mechanical hyperalgesia and cold allodynia correlated well with arthritic score, bone damage parameters and bone damage severity scores. Conclusion: Adjuvant-induced arthritis (AA) were observed after CFA injection and lasted within the later experimental period. Pain-related behavioral changes were observed in the early time of AA. Bone damage was also occurred with arthritis development. Pain-related behavioral change correlated well with arthritic score and bone damage parameters.
