目的探讨地舒单抗相关非典型骨折(AF)的发生特点和规律,为临床合理用药提供参考。方法计算机检索PubMed、Web of Science、中国知网、万方数据、维普网,收集地舒单抗相关AF的个案报道,并进行描述性分析。结果共纳入文献19篇,涉及患者20...目的探讨地舒单抗相关非典型骨折(AF)的发生特点和规律,为临床合理用药提供参考。方法计算机检索PubMed、Web of Science、中国知网、万方数据、维普网,收集地舒单抗相关AF的个案报道,并进行描述性分析。结果共纳入文献19篇,涉及患者20例,其中男性3例、女性17例,平均年龄(69.80±15.39)岁。20例患者中,14例患者的原患疾病为骨质疏松症,6例为实体瘤骨转移和骨巨细胞瘤;AF发生时间为使用地舒单抗后3~132个月,平均(42.14±29.49)个月;14例患者在发生AF前出现了前驱症状;3例患者为尺骨骨折,17例为股骨骨折。绝大多数患者停药并采用手术固定治疗后,恢复良好,但有部分患者出现骨折延迟愈合。结论临床在长期使用地舒单抗时应警惕AF的发生;当患者出现大腿、腹股沟、髋关节和前臂疼痛等前驱症状时应及时就医,以保障用药安全。展开更多
电池监控是电动汽车安全行驶的必要手段,电池的荷电状态(State of Charge,SOC)则是衡量电动汽车安全性能的直接指标。针对锂离子电池的非线性特性,设计一种基于深度学习的长短期记忆网络(Long Short-Term Memory,LSTM)SOC预测模型。通过...电池监控是电动汽车安全行驶的必要手段,电池的荷电状态(State of Charge,SOC)则是衡量电动汽车安全性能的直接指标。针对锂离子电池的非线性特性,设计一种基于深度学习的长短期记忆网络(Long Short-Term Memory,LSTM)SOC预测模型。通过MATLAB实验验证以及与其他算法的比较分析得出,该模型可以有效解决传统神经网络容易陷入局部最小值以及出现梯度消失、爆炸等问题,估算误差小于2%,具有较高的精度和应用前景。展开更多
Whole-rock Rb-Sr, zircon U-Pb and hornblende, biotite and K-feldspar K-Ar ages areused to reconstruct the cooling history of the Huangmeijian intrusion in the Anqing-Lujiangquartz-syenite belt in Anhui. Oxygen isotope...Whole-rock Rb-Sr, zircon U-Pb and hornblende, biotite and K-feldspar K-Ar ages areused to reconstruct the cooling history of the Huangmeijian intrusion in the Anqing-Lujiangquartz-syenite belt in Anhui. Oxygen isotope geothermometry of mineral pairs demonstrates thatdiffusion is a dominant factor controlling the closure of isotopic systems. Assuming the coolingof the intrusion is synchronous with a dicrease in local geothermal gradients, an emplacementdepth of about 8 km and the magma crystallization temperature of 800±50℃ are estimated. TheHuangmeijian intrusion experienced a rapid cooling process and uplifted after its emplacementand crystallization at 133 Ma B.P. with a cooling rate of 34.5℃/Ma and an uplifting rate of 0.35mm/a. The intrusion was rising until it rested at a depth of 3km at a temperature of 300±50℃about 14 Ma later. Then the intrusion was in slow cooling and uplifting with a cooling rate of4.4℃/Ma and an uplifting rate of 0.04 mm/a. U-Pb dating of pitchblende is done for the hydrothermal uranium deposit formed in thecontact zone of the Huangmeijian intrusion. The result shows that the mineralization age is closeto the closing time of the K-Ar system in biotite. The fluid inclusion thermometry indicates thatthe mineralization temperature is in agreement with the closure temperature of the biotite K-Arsystem. This suggests a close relationship between the slow cooling of the intrusion and thehydrothermal uranium mineralization process.展开更多
Four samples of plagioclase and biotite from the Shaxi porphyry in the lower part of the Yangtze metallogenic belt were analyzed for age determination with the ^40 Ar/^39Ar method. The results yield reproducible ages ...Four samples of plagioclase and biotite from the Shaxi porphyry in the lower part of the Yangtze metallogenic belt were analyzed for age determination with the ^40 Ar/^39Ar method. The results yield reproducible ages of 126 Ma to 135 Ma with a high level of confidence according to the agreement between isochron and plateau ages. The four Ar-Ar ages are relatively consistent within the analytical error. These ages are also consistent with, but more precise than, previous K-Ar and Rb-Sr ages and thus provide better constraints on the time of porphyry formation and associated Cu-Au mineralization along the middle to lower part of the Yangtze metallogenic belt. The ages of 126 to 135 Ma are interpreted to represent the intrusive time of the Shaxi porphyry, so that the Cu-Au mineralization should have occurred later due to the post-magmatic hydrothermal event.展开更多
An REE-rich carbonatite dyke was found in Dulahala, close to the Bayan Obo superlarge REE-Nb-Fe mineral deposit in Inner Mongolia, northern China. The REE content in the dyke varies greatly, from 1% up to 20% (wt), wh...An REE-rich carbonatite dyke was found in Dulahala, close to the Bayan Obo superlarge REE-Nb-Fe mineral deposit in Inner Mongolia, northern China. The REE content in the dyke varies greatly, from 1% up to 20% (wt), which might constitute rich REE ores. Light REEs in the carbonatite are enriched and highly fractionated relative to heavy REEs and there is no Eu anomaly. The REE and trace element distribution patterns of the carbonatite are identical to those of fine-grained dolomite marble which is the host rock of the Bayan Obo REE-Nb-Fe superlarge mineral deposit. This indicates a petrogenetic linkage between the REE-rich carbonatite and the mineralizations in this region.展开更多
The subduction channel is the dynamic site of mass and energy exchange between the slab and mantle. It is evolved into the subduction factory by processing raw materials into different products. The raw materials are ...The subduction channel is the dynamic site of mass and energy exchange between the slab and mantle. It is evolved into the subduction factory by processing raw materials into different products. The raw materials are sedimentary crust, igneous crust, and lithospheric mantle （juvenile or ancient）. They are carried with the subducting slab and undergo physicochemical modification by metamorphic dehydration and partial melting, producing metasomatic agents in the forms of aqueous solutions,展开更多
文摘目的探讨地舒单抗相关非典型骨折(AF)的发生特点和规律,为临床合理用药提供参考。方法计算机检索PubMed、Web of Science、中国知网、万方数据、维普网,收集地舒单抗相关AF的个案报道,并进行描述性分析。结果共纳入文献19篇,涉及患者20例,其中男性3例、女性17例,平均年龄(69.80±15.39)岁。20例患者中,14例患者的原患疾病为骨质疏松症,6例为实体瘤骨转移和骨巨细胞瘤;AF发生时间为使用地舒单抗后3~132个月,平均(42.14±29.49)个月;14例患者在发生AF前出现了前驱症状;3例患者为尺骨骨折,17例为股骨骨折。绝大多数患者停药并采用手术固定治疗后,恢复良好,但有部分患者出现骨折延迟愈合。结论临床在长期使用地舒单抗时应警惕AF的发生;当患者出现大腿、腹股沟、髋关节和前臂疼痛等前驱症状时应及时就医,以保障用药安全。
文摘电池监控是电动汽车安全行驶的必要手段,电池的荷电状态(State of Charge,SOC)则是衡量电动汽车安全性能的直接指标。针对锂离子电池的非线性特性,设计一种基于深度学习的长短期记忆网络(Long Short-Term Memory,LSTM)SOC预测模型。通过MATLAB实验验证以及与其他算法的比较分析得出,该模型可以有效解决传统神经网络容易陷入局部最小值以及出现梯度消失、爆炸等问题,估算误差小于2%,具有较高的精度和应用前景。
文摘Whole-rock Rb-Sr, zircon U-Pb and hornblende, biotite and K-feldspar K-Ar ages areused to reconstruct the cooling history of the Huangmeijian intrusion in the Anqing-Lujiangquartz-syenite belt in Anhui. Oxygen isotope geothermometry of mineral pairs demonstrates thatdiffusion is a dominant factor controlling the closure of isotopic systems. Assuming the coolingof the intrusion is synchronous with a dicrease in local geothermal gradients, an emplacementdepth of about 8 km and the magma crystallization temperature of 800±50℃ are estimated. TheHuangmeijian intrusion experienced a rapid cooling process and uplifted after its emplacementand crystallization at 133 Ma B.P. with a cooling rate of 34.5℃/Ma and an uplifting rate of 0.35mm/a. The intrusion was rising until it rested at a depth of 3km at a temperature of 300±50℃about 14 Ma later. Then the intrusion was in slow cooling and uplifting with a cooling rate of4.4℃/Ma and an uplifting rate of 0.04 mm/a. U-Pb dating of pitchblende is done for the hydrothermal uranium deposit formed in thecontact zone of the Huangmeijian intrusion. The result shows that the mineralization age is closeto the closing time of the K-Ar system in biotite. The fluid inclusion thermometry indicates thatthe mineralization temperature is in agreement with the closure temperature of the biotite K-Arsystem. This suggests a close relationship between the slow cooling of the intrusion and thehydrothermal uranium mineralization process.
基金This study is supported by funds from the Ministry of Science and Technology of China （2006CB403500） ； National Natural Science Foundation of China （40473021）.
文摘Four samples of plagioclase and biotite from the Shaxi porphyry in the lower part of the Yangtze metallogenic belt were analyzed for age determination with the ^40 Ar/^39Ar method. The results yield reproducible ages of 126 Ma to 135 Ma with a high level of confidence according to the agreement between isochron and plateau ages. The four Ar-Ar ages are relatively consistent within the analytical error. These ages are also consistent with, but more precise than, previous K-Ar and Rb-Sr ages and thus provide better constraints on the time of porphyry formation and associated Cu-Au mineralization along the middle to lower part of the Yangtze metallogenic belt. The ages of 126 to 135 Ma are interpreted to represent the intrusive time of the Shaxi porphyry, so that the Cu-Au mineralization should have occurred later due to the post-magmatic hydrothermal event.
基金supported by the National Natural Science Foundation of China(grant No.49872032)for YXMthe Ministry of Science and Technology of China(grant No.G1999043204)for ZYF
文摘An REE-rich carbonatite dyke was found in Dulahala, close to the Bayan Obo superlarge REE-Nb-Fe mineral deposit in Inner Mongolia, northern China. The REE content in the dyke varies greatly, from 1% up to 20% (wt), which might constitute rich REE ores. Light REEs in the carbonatite are enriched and highly fractionated relative to heavy REEs and there is no Eu anomaly. The REE and trace element distribution patterns of the carbonatite are identical to those of fine-grained dolomite marble which is the host rock of the Bayan Obo REE-Nb-Fe superlarge mineral deposit. This indicates a petrogenetic linkage between the REE-rich carbonatite and the mineralizations in this region.
文摘The subduction channel is the dynamic site of mass and energy exchange between the slab and mantle. It is evolved into the subduction factory by processing raw materials into different products. The raw materials are sedimentary crust, igneous crust, and lithospheric mantle （juvenile or ancient）. They are carried with the subducting slab and undergo physicochemical modification by metamorphic dehydration and partial melting, producing metasomatic agents in the forms of aqueous solutions,
