A chiral Lewis base organocatalyzed enantioselective hydrosilylation ofa-keto ketimines was investigated.The reactions afforded various enantioenriched a-amino ketones with good yields(up to 95%) in moderate to goo...A chiral Lewis base organocatalyzed enantioselective hydrosilylation ofa-keto ketimines was investigated.The reactions afforded various enantioenriched a-amino ketones with good yields(up to 95%) in moderate to good enantioselectivities(up to 98% e.e.).Furthermore,one of the products was reduced to a chiral 1,2-amino alcohol.Following cyclization of it with triphosgene generated a cannabinoid receptor 1 (CB 1) inhibitor with good diastereoselectivity.展开更多
基金Supported by the National Natural Science Foundation of China(No.20972155).
文摘A chiral Lewis base organocatalyzed enantioselective hydrosilylation ofa-keto ketimines was investigated.The reactions afforded various enantioenriched a-amino ketones with good yields(up to 95%) in moderate to good enantioselectivities(up to 98% e.e.).Furthermore,one of the products was reduced to a chiral 1,2-amino alcohol.Following cyclization of it with triphosgene generated a cannabinoid receptor 1 (CB 1) inhibitor with good diastereoselectivity.