A combined arrival and departure scheduling problem is investigated for multi-airport system to alleviate the problem of airspace congestion and flight delay.Firstly,the combined scheduling problem for multi-airport s...A combined arrival and departure scheduling problem is investigated for multi-airport system to alleviate the problem of airspace congestion and flight delay.Firstly,the combined scheduling problem for multi-airport system is defined through in-depth analysis of the characteristics of arrival and departure operations.Then,several constraints are taken into account,such as wake vortex separation,transfer separation,release separation,and separation in different runway operational modes.Furthermore,the scheduling model is constructed and simulated annealing algorithm is proposed by minimizing the total delay.Finally,Shanghai multi-airport system is chosen to conduct the simulation and validation.And the simulation results indicate that the proposed method is able to effectively improve the efficiency of arrival and departure operations for multi-airport system.展开更多
Objective： To explore the diagnosis and treatment experience of breast cancer associated with pregnancy or lactation. Methods： From January 1990 to December 2005, 14 cases with breast cancer associated with pregnanc...Objective： To explore the diagnosis and treatment experience of breast cancer associated with pregnancy or lactation. Methods： From January 1990 to December 2005, 14 cases with breast cancer associated with pregnancy or lactation were analyzed retrospectively （TNM stage Ⅱ, 2 cases; stage Ⅲ, 11 cases; stage Ⅳ, 1 case）. Diagnosis was established by fine needle aspiration biopsy primarily or routine pathological method if necessary. Abortion was used for discontinuation of pregnancy in 1 case with early pregnancy and 1 case with meddle pregnancy. 2 patients with late pregnancy received cesarean section, 10patients of breast cancer associated with lactation received multidisciplinary and-tumor treatment after discontinuation of lactation. Results： Diagnosis was confirmed by fine noodle aspiration biopsy in 9 cases and by secondary routine pathological method in the other 5 cases, 12 cases were followed up, 1 case of stage Ⅳ died of metastasis 5 months after diagnosis. 3-, 5-year survival rates in 10 cases of stage Ⅲ were 66% and 30% respectively. One case remained alive without recurrence for 8 years up to now. Conclusion： A thorough breast examination is necessary at the first antenatal visit physicians should aggressively pursue work-up in women with a palpable breast tass. In the patients during the second and third trimness, the various modalities available for treatment inholding abortion and their risks and beneath modalities available for treatment including abortion and their risks and benefits must be discussed openly with patients and their families.展开更多
基金supported by the National Natural Science Foundation of China(No.71401072)the National Natural Science Foundation of Jiangsu Province(No.BK20130814)the Foundation of Jiangsu Innovation Program for Graduate Education(the Fundamental Research Funds for the Central Universities,No.SJLX15_0128)
文摘A combined arrival and departure scheduling problem is investigated for multi-airport system to alleviate the problem of airspace congestion and flight delay.Firstly,the combined scheduling problem for multi-airport system is defined through in-depth analysis of the characteristics of arrival and departure operations.Then,several constraints are taken into account,such as wake vortex separation,transfer separation,release separation,and separation in different runway operational modes.Furthermore,the scheduling model is constructed and simulated annealing algorithm is proposed by minimizing the total delay.Finally,Shanghai multi-airport system is chosen to conduct the simulation and validation.And the simulation results indicate that the proposed method is able to effectively improve the efficiency of arrival and departure operations for multi-airport system.
文摘Objective： To explore the diagnosis and treatment experience of breast cancer associated with pregnancy or lactation. Methods： From January 1990 to December 2005, 14 cases with breast cancer associated with pregnancy or lactation were analyzed retrospectively （TNM stage Ⅱ, 2 cases; stage Ⅲ, 11 cases; stage Ⅳ, 1 case）. Diagnosis was established by fine needle aspiration biopsy primarily or routine pathological method if necessary. Abortion was used for discontinuation of pregnancy in 1 case with early pregnancy and 1 case with meddle pregnancy. 2 patients with late pregnancy received cesarean section, 10patients of breast cancer associated with lactation received multidisciplinary and-tumor treatment after discontinuation of lactation. Results： Diagnosis was confirmed by fine noodle aspiration biopsy in 9 cases and by secondary routine pathological method in the other 5 cases, 12 cases were followed up, 1 case of stage Ⅳ died of metastasis 5 months after diagnosis. 3-, 5-year survival rates in 10 cases of stage Ⅲ were 66% and 30% respectively. One case remained alive without recurrence for 8 years up to now. Conclusion： A thorough breast examination is necessary at the first antenatal visit physicians should aggressively pursue work-up in women with a palpable breast tass. In the patients during the second and third trimness, the various modalities available for treatment inholding abortion and their risks and beneath modalities available for treatment including abortion and their risks and benefits must be discussed openly with patients and their families.
