Flavonoids are a class of phytochemical molecules abundant in many plants,fruits,vegetables,and leaves.Flavonoids possess a series of significant biological activities,including anticancer,antioxidant,antiviral,and an...Flavonoids are a class of phytochemical molecules abundant in many plants,fruits,vegetables,and leaves.Flavonoids possess a series of significant biological activities,including anticancer,antioxidant,antiviral,and antiinflammatory properties.They become an important source of dietary supplements and natural health products.Though many studies confirmed the safety of flavonoids,the potential toxicity of flavonoids is still a remarkable field of research to be explored.The enthusiasm for flavonoids expressed by the public has sometimes overlooked their toxicity and also consumed the flavonoids exceeding the body requirements.The current review focused on the potential toxicity of flavonoids to make the public consume flavonoids with caution.This review summarizes the current toxicity which has been reported in vivo and in vitro experiments.The toxicity involves carcinogenicity and mutation,liver and kidney toxicity,and the influence on the thyroid and reproductive function and intestinal flora disorders.The mechanism of toxicity is fully complicated,and current evidence indicates that natural flavonoid glycosides act on different targets with different doses in vivo and in vitro experiments.Though most kinds of flavonoids are considered safe,flavonoids proposed as food supplements need to be assessed their tolerable upper intake level as there have been reports of toxic flavonoids.展开更多
基金supported by grants from the Research Platforms and Projects of Universities in Guangdong Province(2020ZDZX1027)Projects of PhDs’Start-up Research of GDUPT(702-519221)+1 种基金Projects of Talents Recruitment of GDUPT(519030)from the Outstanding Innovation Team Project of Basic Scientific Research Operating Expenses of Provincial Universities in Heilongjiang Province(2018-KYYWF-0915).
文摘Flavonoids are a class of phytochemical molecules abundant in many plants,fruits,vegetables,and leaves.Flavonoids possess a series of significant biological activities,including anticancer,antioxidant,antiviral,and antiinflammatory properties.They become an important source of dietary supplements and natural health products.Though many studies confirmed the safety of flavonoids,the potential toxicity of flavonoids is still a remarkable field of research to be explored.The enthusiasm for flavonoids expressed by the public has sometimes overlooked their toxicity and also consumed the flavonoids exceeding the body requirements.The current review focused on the potential toxicity of flavonoids to make the public consume flavonoids with caution.This review summarizes the current toxicity which has been reported in vivo and in vitro experiments.The toxicity involves carcinogenicity and mutation,liver and kidney toxicity,and the influence on the thyroid and reproductive function and intestinal flora disorders.The mechanism of toxicity is fully complicated,and current evidence indicates that natural flavonoid glycosides act on different targets with different doses in vivo and in vitro experiments.Though most kinds of flavonoids are considered safe,flavonoids proposed as food supplements need to be assessed their tolerable upper intake level as there have been reports of toxic flavonoids.
