COMP ARISON OF MACROMOLECULAR COMPONENT DISTRIBUTIONS IN OSTEOARTHRITIC AND HEALTHY CARTILAGES BY FOURIER TRANSFORM INFRARED IMAGING

Fourier transform infrared imaging(FTIRI)was used to examine the depth-dependent content variations of macromolcular components,ollagen and protooglycan(PG),in osteoarthritic and healthy cartilages.Dried 6 pmm thick sections of canine knee cartilages were imaged at 6.25 pμrm pixel-size in FTIRI.By analyzing the infrared(IR)images and spectra,the depth dependence of characteristic band(sugar)intensity of PG show obvious difference bet ween the cartilage sections of(OA)and bealth.The result confimns that PG content decreases in the ostcoarthritic cartilage.However,no clear change occurs to collagen,suggesting that the OA influences little on the collagen content at early stage of OA.This observation will be helpful to further understand PG loss associated with pathological conditions in OA,and demonstrates that FIIRI has the po-tential to become an important analytical tool to identify early clinical signs of tissue degna-dation,such as PG loss even collagen disruption.

Associations of Sport Participation with Depression and Anxiety among Chinese Minority Adolescents

This study aimed to explore associations of sport participation with anxiety and depressive symptoms among Chi-nese minority adolescents.A cross-sectional study was conducted among Chinese adolescents in Tibet.A conve-nience sample method was used to select participants.Finally,1452 students completed the survey and 1421(52.10%girls,Grades 4–9,13.46±1.41 years old)adolescents met the inclusion criteria of analysis.Sociodemo-graphic variables,sport participation,depression and anxiety were evaluated by self-reported questionnaires.Among 1421 participants,80%of adolescents lived in rural area and more than fourfifths of participants had siblings.The parent’s education level of participants was mostly middle school and below.The prevalence of par-ticipating in sport more than 3 times per week was only 7%.More than one-third of adolescents reported they never engaged in sport and 36.5%of adolescents took part in sport 1–3 times per month.In comparison with participants who never engaging in sport participation,those who engaging in one to three time/month(OR=0.71%,95%CI:0.54–0.93)and more than 3 times/week(OR=0.50%,95%CI:0.32–0.79)were less likely to report severe depression symptoms.Compared with participants who never had sport participation,only those counterparts who engaged in sport more than 3 times/week had lower odds for severe anxiety(OR=0.46%,95%CI:0.29–0.73).These results indicated that engaging in sport participation was negatively associated with depres-sion and anxiety.There is an urgent need to improve the level of sport participation for Chinese minority ado-lescents,and to explore the mechanism of exercise under hypoxia on mental health.

Novel benzamido derivatives as PTP1B inhibitors with anti-hyperglycemic and lipid-lowering efficacy

Based on a non-competitive and selective PTP1 B inhibitor reported by us previously, thirtynine benzamido derivatives were designed and synthesized as novel PTP1 B inhibitors. Among them,twelve compounds exhibited IC_(50) values at micromolar level against human recombinant PTP1 B, and most of them exhibited significant selectivity to PTP1 B over TC-PTP and CD45. Further evaluation of the most potent compound 27 on high-fat diet(HFD)-induced insulin-resistant(IR) obese mice indicated that27 could modulate glucose metabolism and ameliorate dyslipidemia simultaneously.& 2018 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license(http://creativecommons.org/licenses/by-nc-nd/4.0/).