目的:探讨血小板与白细胞比值(platelet and white blood cells ratio, PWR)、血小板与淋巴细胞比值(platelet and lymphocyte ratio, PLR)、中性粒细胞与淋巴细胞比值(neutrophil to lymphocyte ratio, NLR)以及尿白细胞计数(urinary l...目的:探讨血小板与白细胞比值(platelet and white blood cells ratio, PWR)、血小板与淋巴细胞比值(platelet and lymphocyte ratio, PLR)、中性粒细胞与淋巴细胞比值(neutrophil to lymphocyte ratio, NLR)以及尿白细胞计数(urinary leucocyte count, ULEU)与接受PD-1抑制剂治疗晚期尿路上皮癌(urothelial carcinoma, UC)患者预后的关系。方法:收集78例接受PD-1抑制剂治疗晚期UC患者的临床资料,利用Kaplan-Meier法计算生存率和Log-rank检验比较不同组间的生存差异,同时采用COX回归分析预后影响因素。结果:低PLR组与高PLR组的1年生存率分别为71.98%和47.63%,差异有统计学意义(P<0.05);低NLR组与高NLR组的1年生存率分别为71.36%和48.15%,差异有统计学意义(P<0.05);PWR高低两组和ULEU状态预测UC患者生存率无显著性差异(P>0.05)。单因素回归分析结果显示,N分期、M分期、TNM分期、远处转移个数、PLR、NLR是影响晚期UC患者生存情况的危险因素(P<0.05)。多因素回归分析显示,PLR是影响接受PD-1抑制剂治疗的UC患者预后的独立因素。结论:PLR、NLR为影响接受PD-1抑制剂治疗晚期UC患者预后的独立因素,PLR高值组和NLR高值组患者的预后较PLR低值组和NLR低值组的患者差。展开更多
The Jiangshan gold deposit is the largest,most recently-discovered gold deposit in the Bengbu Uplift.The ore bodies are located in the structural fracture zone of the Zhuangzili Formation(Ar3),with major Pb-Zn and Au ...The Jiangshan gold deposit is the largest,most recently-discovered gold deposit in the Bengbu Uplift.The ore bodies are located in the structural fracture zone of the Zhuangzili Formation(Ar3),with major Pb-Zn and Au reserves.In this study,LA-ICP-MS zircon U-Pb analyses yielded a crystallization age of 111.5±1.8 Ma for the quartz diorite porphyry in Jiangshan.The quartz diorite porphyry has high Ba and Sr content,with low Y and Yb content,which is similar to the characteristics of adakitic rocks.They are enriched in large ion lithophile elements(LILEs,e.g.,Ba,U)and light rare ear th elements(LREEs),while depleted in high field strength elements(HFSEs,e.g.,Nb,Ti)and heavy rare earth element(HREEs).They have zirconεHf(t)values of-23.52 to-21.14(mean=-22.32).and Hf model ages of 2419.76 to 2569.39 Ma.The magma source area is the lower crust.Magma primarily came from the partial melting of the lower crust,with the addition of some mantle material.The quartz diorite porphyries are characterized by high zircon TTi-in-zircon values(608-757°C),Ce^4+/Ce^3+ratios(71.97-1387.10)and Eu/Eu*ratios(0.46-1.08),indicating high temperature and magmatic oxygen fugacities.High temperatures can provide heat to fluids and highly oxidized magmas can control the behavior and speciation of sulfides,thus controlling the behavior of Au.Finally,the ore-forming fluid is enriched and precipitated in a favorable structural space to form the Jiangshan Au deposit.展开更多
Digital transformation has brought new vitality into enterprises'innovative development.Traditional manufacturing industries have leveraged digitalization to drive technological advancements,thereby promoting corp...Digital transformation has brought new vitality into enterprises'innovative development.Traditional manufacturing industries have leveraged digitalization to drive technological advancements,thereby promoting corporate green technology innovation and achieving the goal of coordinated transformation toward digital and green development.This paper employs annual data of China's A-share listed manufacturing companies from 2007 to 2020 to examine the impact of digital transformation on corporate green technology innovation and the underlying mechanism of this impact.The results indicate that digital transformation significantly enhances corporate green technology innovation,and this enhancing effect is even more significant in state-owned enterprises and high-tech enterprises.The mechanism test reveals that enhancing digital transformation can not only improve enterprises'information transparency and strengthen positive market expectations,but also encourage enterprises to increase R&D investment,ultimately enhancing the level of their green technology innovation.The empirical findings of this paper can provide valuable insights for government departments to formulate strategies that can promote green innovation in the manufacturing industry,drive high-quality development,and contribute to the achievement of carbon peaking and carbon neutrality targets.展开更多
文摘目的:探讨血小板与白细胞比值(platelet and white blood cells ratio, PWR)、血小板与淋巴细胞比值(platelet and lymphocyte ratio, PLR)、中性粒细胞与淋巴细胞比值(neutrophil to lymphocyte ratio, NLR)以及尿白细胞计数(urinary leucocyte count, ULEU)与接受PD-1抑制剂治疗晚期尿路上皮癌(urothelial carcinoma, UC)患者预后的关系。方法:收集78例接受PD-1抑制剂治疗晚期UC患者的临床资料,利用Kaplan-Meier法计算生存率和Log-rank检验比较不同组间的生存差异,同时采用COX回归分析预后影响因素。结果:低PLR组与高PLR组的1年生存率分别为71.98%和47.63%,差异有统计学意义(P<0.05);低NLR组与高NLR组的1年生存率分别为71.36%和48.15%,差异有统计学意义(P<0.05);PWR高低两组和ULEU状态预测UC患者生存率无显著性差异(P>0.05)。单因素回归分析结果显示,N分期、M分期、TNM分期、远处转移个数、PLR、NLR是影响晚期UC患者生存情况的危险因素(P<0.05)。多因素回归分析显示,PLR是影响接受PD-1抑制剂治疗的UC患者预后的独立因素。结论:PLR、NLR为影响接受PD-1抑制剂治疗晚期UC患者预后的独立因素,PLR高值组和NLR高值组患者的预后较PLR低值组和NLR低值组的患者差。
基金grant-funded by the National Key R&D Program of China(2016YFC0600404)the Key R&D Program of Anhui Province(201904a07020077)the Natural Science Foundation of China(41673040)。
文摘The Jiangshan gold deposit is the largest,most recently-discovered gold deposit in the Bengbu Uplift.The ore bodies are located in the structural fracture zone of the Zhuangzili Formation(Ar3),with major Pb-Zn and Au reserves.In this study,LA-ICP-MS zircon U-Pb analyses yielded a crystallization age of 111.5±1.8 Ma for the quartz diorite porphyry in Jiangshan.The quartz diorite porphyry has high Ba and Sr content,with low Y and Yb content,which is similar to the characteristics of adakitic rocks.They are enriched in large ion lithophile elements(LILEs,e.g.,Ba,U)and light rare ear th elements(LREEs),while depleted in high field strength elements(HFSEs,e.g.,Nb,Ti)and heavy rare earth element(HREEs).They have zirconεHf(t)values of-23.52 to-21.14(mean=-22.32).and Hf model ages of 2419.76 to 2569.39 Ma.The magma source area is the lower crust.Magma primarily came from the partial melting of the lower crust,with the addition of some mantle material.The quartz diorite porphyries are characterized by high zircon TTi-in-zircon values(608-757°C),Ce^4+/Ce^3+ratios(71.97-1387.10)and Eu/Eu*ratios(0.46-1.08),indicating high temperature and magmatic oxygen fugacities.High temperatures can provide heat to fluids and highly oxidized magmas can control the behavior and speciation of sulfides,thus controlling the behavior of Au.Finally,the ore-forming fluid is enriched and precipitated in a favorable structural space to form the Jiangshan Au deposit.
文摘Digital transformation has brought new vitality into enterprises'innovative development.Traditional manufacturing industries have leveraged digitalization to drive technological advancements,thereby promoting corporate green technology innovation and achieving the goal of coordinated transformation toward digital and green development.This paper employs annual data of China's A-share listed manufacturing companies from 2007 to 2020 to examine the impact of digital transformation on corporate green technology innovation and the underlying mechanism of this impact.The results indicate that digital transformation significantly enhances corporate green technology innovation,and this enhancing effect is even more significant in state-owned enterprises and high-tech enterprises.The mechanism test reveals that enhancing digital transformation can not only improve enterprises'information transparency and strengthen positive market expectations,but also encourage enterprises to increase R&D investment,ultimately enhancing the level of their green technology innovation.The empirical findings of this paper can provide valuable insights for government departments to formulate strategies that can promote green innovation in the manufacturing industry,drive high-quality development,and contribute to the achievement of carbon peaking and carbon neutrality targets.
