目的:探讨医院-社区-家庭三元联动管理在脑卒中后抑郁患者中的应用效果。方法:我院的92例脑卒中后抑郁患者被随机分为常规治疗组,联动管理组(接受医院-社区-家庭三元联动管理),干预3个月后,比较两组患者干预前后焦虑、抑郁评分,健康调...目的:探讨医院-社区-家庭三元联动管理在脑卒中后抑郁患者中的应用效果。方法:我院的92例脑卒中后抑郁患者被随机分为常规治疗组,联动管理组(接受医院-社区-家庭三元联动管理),干预3个月后,比较两组患者干预前后焦虑、抑郁评分,健康调查简表(SF-36)评分及对医生服务的满意度。结果:与治疗前比较,干预3个月后,两组患者焦虑、抑郁自评量表评分均显著下降,SF-36量表评分和患者对医生服务满意度各项评分均显著升高( P 均=0.001);且与常规治疗组比较,联动管理组患者焦虑[(41.10±1.73)分比(38.22±1.53)分]、抑郁自评量表[(43.14±1.93)分比(39.44±1.85)分]评分下降更显著,SF-36量表评分[(68.35±4.44)分比(87.64±4.36)分]和患者对医生服务满意度各项评分升高更显著( P 均=0.001)。结论:医院-社区-家庭三元联动管理能够显著改善脑卒中后抑郁患者焦虑抑郁情绪,提高患者生活质量及患者对医护服务满意度,值得推广。展开更多
Objective: To study the pharmacokinetic, distribution and elimination properties of rhTα 1 after intravenous(i.v.) and subcutaneous(s.c.)injection in mice and rats. Methods: Competition ELISA was used for testing dru...Objective: To study the pharmacokinetic, distribution and elimination properties of rhTα 1 after intravenous(i.v.) and subcutaneous(s.c.)injection in mice and rats. Methods: Competition ELISA was used for testing drug concentration in serum, urine, bile and tissue after administration of rhTα 1 in mice(0.16, 0.5, 2.5 mg/kg) and rats(0.32, 1, 5 mg/kg). Pharmacokinetic parameters were calculated by Win Nolin software. Results: Absorption of rh Tαl is rapid in both mice and rats after s.c. administration. The pharmacokinetics in mice are characterized by linear, T_(1/2) showed a prolongation with increasing dose, 1.10, 1.35, and 1.50 h corresponding to 0.32, 1 and 5 mg/kg respectively, but in rats T_(1/2) showed no difference among doses. AUC0-∞ showed a clear increase with increasing doses in mice(904.18, 2998.83, and 19001.82 h*ng/m L) and in rats(1327.56 ±237.00,2924.53 ±685.14, and 35286.26 ±5999.58 h*ng/m L). After i.v. administration of 1 mg/kg rhTα 1 in mice, the drug is seen distributed in most organs, the thymus/serum exposure ratio was higher than others at the 1 and 2 h, the accumulative urinary excretion of primary drug was 32.97% ±15.85% within 6 h. Conclusion: The results indicate that rapid absorption, extensive distribution and quick renal excretion were the basic kinetic characteristics of rh Tαl after s.c. and i.v. administration.展开更多
文摘目的:探讨医院-社区-家庭三元联动管理在脑卒中后抑郁患者中的应用效果。方法:我院的92例脑卒中后抑郁患者被随机分为常规治疗组,联动管理组(接受医院-社区-家庭三元联动管理),干预3个月后,比较两组患者干预前后焦虑、抑郁评分,健康调查简表(SF-36)评分及对医生服务的满意度。结果:与治疗前比较,干预3个月后,两组患者焦虑、抑郁自评量表评分均显著下降,SF-36量表评分和患者对医生服务满意度各项评分均显著升高( P 均=0.001);且与常规治疗组比较,联动管理组患者焦虑[(41.10±1.73)分比(38.22±1.53)分]、抑郁自评量表[(43.14±1.93)分比(39.44±1.85)分]评分下降更显著,SF-36量表评分[(68.35±4.44)分比(87.64±4.36)分]和患者对医生服务满意度各项评分升高更显著( P 均=0.001)。结论:医院-社区-家庭三元联动管理能够显著改善脑卒中后抑郁患者焦虑抑郁情绪,提高患者生活质量及患者对医护服务满意度,值得推广。
基金Natural Science Foundation of Gansu Provincegrant number:1506RJZA278
文摘Objective: To study the pharmacokinetic, distribution and elimination properties of rhTα 1 after intravenous(i.v.) and subcutaneous(s.c.)injection in mice and rats. Methods: Competition ELISA was used for testing drug concentration in serum, urine, bile and tissue after administration of rhTα 1 in mice(0.16, 0.5, 2.5 mg/kg) and rats(0.32, 1, 5 mg/kg). Pharmacokinetic parameters were calculated by Win Nolin software. Results: Absorption of rh Tαl is rapid in both mice and rats after s.c. administration. The pharmacokinetics in mice are characterized by linear, T_(1/2) showed a prolongation with increasing dose, 1.10, 1.35, and 1.50 h corresponding to 0.32, 1 and 5 mg/kg respectively, but in rats T_(1/2) showed no difference among doses. AUC0-∞ showed a clear increase with increasing doses in mice(904.18, 2998.83, and 19001.82 h*ng/m L) and in rats(1327.56 ±237.00,2924.53 ±685.14, and 35286.26 ±5999.58 h*ng/m L). After i.v. administration of 1 mg/kg rhTα 1 in mice, the drug is seen distributed in most organs, the thymus/serum exposure ratio was higher than others at the 1 and 2 h, the accumulative urinary excretion of primary drug was 32.97% ±15.85% within 6 h. Conclusion: The results indicate that rapid absorption, extensive distribution and quick renal excretion were the basic kinetic characteristics of rh Tαl after s.c. and i.v. administration.
