Product data management (PDM) is a new technique that is developed from database management system (DBMS) to manage the information and the associated procedure of a product. Many design engineers have employed PDM to...Product data management (PDM) is a new technique that is developed from database management system (DBMS) to manage the information and the associated procedure of a product. Many design engineers have employed PDM tools to coordinate and control access to documented versions of product designs. But it is still a focus of research efforts in industry and academic how to further build an efficient and effective integrated product/process development environments (IPDEs) based on PDM to meet requirements of enterprises. This paper introduces the approach to design and implementation of an integrated CAD/CAPP system (IC2S) based on PDM. This system is an important compent of computer integrated manufacturing system in KELON Inc(Kelon-CIMS). It is mainly used to support for the design and development of the home electric appliances (HEA).展开更多
A version of a product consists of the product structure tree and the versions of all its components. The model includes two sets of data： attributes and documents describing each component. The paper discusses the v...A version of a product consists of the product structure tree and the versions of all its components. The model includes two sets of data： attributes and documents describing each component. The paper discusses the version change relations between a sub-node component and a up-node component in a product structure tree, analyzes the version control system for a static reference and that for a dynamic reference and proposes a product structure model in support of dynamic reference, which is easy to use and contains a complete set of information providing an essential way of data organization for the PDM system.展开更多
目的对人结肠癌LoVo细胞的果蝇zeste基因增强子同源物2(enhancer of zeste homo-log 2,EZH2)基因进行沉默并对其侵袭和转移功能研究,探索干扰EZH2是否是结肠癌细胞的治疗潜在靶点。方法设计并合成针对人EZH2基因的shRNA引物,并将其基因...目的对人结肠癌LoVo细胞的果蝇zeste基因增强子同源物2(enhancer of zeste homo-log 2,EZH2)基因进行沉默并对其侵袭和转移功能研究,探索干扰EZH2是否是结肠癌细胞的治疗潜在靶点。方法设计并合成针对人EZH2基因的shRNA引物,并将其基因连接至pLVX-shRNA2质粒载体上,通过脂质体Lipodfectine2000转染人结肠癌LoVo细胞,通过免疫印迹鉴定EZH2的表达。并用Transwell方法研究干扰人EZH2基因对人结肠癌LoVo细胞的侵袭结果,细胞划痕实验研究干扰人EZH2基因对人结肠癌LoVo细胞的迁移结果。结果成功构建干扰人EZH2表达的p LVX-shRNA2质粒载体,有效抑制EZH2基因的表达。功能研究初步证明,干扰EZH2基因表达可抑制人结肠癌LoVo细胞的侵袭及细胞迁移。结论沉默EZH2基因显著下调人结肠癌LoVo细胞的侵袭和转移功能,可作为结肠癌治疗的潜在靶点之一。展开更多
文摘Product data management (PDM) is a new technique that is developed from database management system (DBMS) to manage the information and the associated procedure of a product. Many design engineers have employed PDM tools to coordinate and control access to documented versions of product designs. But it is still a focus of research efforts in industry and academic how to further build an efficient and effective integrated product/process development environments (IPDEs) based on PDM to meet requirements of enterprises. This paper introduces the approach to design and implementation of an integrated CAD/CAPP system (IC2S) based on PDM. This system is an important compent of computer integrated manufacturing system in KELON Inc(Kelon-CIMS). It is mainly used to support for the design and development of the home electric appliances (HEA).
基金Supported by the Fundamental Fujian Nature Science (A0440006) and Xiamen Science & Technology Project (3502Z20055028)
文摘A version of a product consists of the product structure tree and the versions of all its components. The model includes two sets of data： attributes and documents describing each component. The paper discusses the version change relations between a sub-node component and a up-node component in a product structure tree, analyzes the version control system for a static reference and that for a dynamic reference and proposes a product structure model in support of dynamic reference, which is easy to use and contains a complete set of information providing an essential way of data organization for the PDM system.
