Hypoxia-inducible factor 1(HIF-1),as a main transcriptional regulator of metabolic adaptation to changes in the oxygen environment,participates in many physiological and pathological processes in the body,and is close...Hypoxia-inducible factor 1(HIF-1),as a main transcriptional regulator of metabolic adaptation to changes in the oxygen environment,participates in many physiological and pathological processes in the body,and is closely related to the pathogenesis of many diseases.This review outlines the mechanisms of HIF-1 activation,its signaling pathways,natural inhibitors,and its roles in diseases.This article can provide new insights in the diagnosis and treatment of human diseases,and recent progress on the development of HIF-1 inhibitors.展开更多
基金supported by the Open Project of State Key Laboratory of Natural Medicines(No.SKLNMKF 202005)the Macao Science and Technology Development Fund(No.071/2017/A2).
文摘Hypoxia-inducible factor 1(HIF-1),as a main transcriptional regulator of metabolic adaptation to changes in the oxygen environment,participates in many physiological and pathological processes in the body,and is closely related to the pathogenesis of many diseases.This review outlines the mechanisms of HIF-1 activation,its signaling pathways,natural inhibitors,and its roles in diseases.This article can provide new insights in the diagnosis and treatment of human diseases,and recent progress on the development of HIF-1 inhibitors.
