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妊娠期胆总管结石的诊治进展
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作者 杨森 利民 +6 位作者 高志光 张涛 李世鹏 叶超荣 舒苗江 钟振威 郑超 《胃肠病学和肝病学杂志》 CAS 2023年第4期443-447,共5页
胆总管结石是临床常见病,而妊娠合并胆总管结石病则相对较少。手术及内镜逆行胰胆管造影术(endoscopic retrograde cholangiopancreatography,ERCP)所涉及的电离辐射可能对孕妇造成流产或早产,对胎儿造成畸形或儿童期肿瘤等影响。因此,... 胆总管结石是临床常见病,而妊娠合并胆总管结石病则相对较少。手术及内镜逆行胰胆管造影术(endoscopic retrograde cholangiopancreatography,ERCP)所涉及的电离辐射可能对孕妇造成流产或早产,对胎儿造成畸形或儿童期肿瘤等影响。因此,选择合适的诊疗方案对获得良好妊娠结局尤为重要。我们就近年的相关文献,对妊娠期胆总管结石的诊疗现状和进展作一综述。 展开更多
关键词 胆总管结石 腔内超声检查 内镜逆行胰胆管造影术 腹腔镜胆总管探查术 妊娠期
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Monitoring Glacier and Supra-glacier Lakes from Space in Mt. Qomolangma Region of the Himalayas on the Tibetan Plateau in China 被引量:27
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作者 YE Qinghua zhong zhenwei +3 位作者 KANG Shichang Alfred Stein WEI Qiufang LIU Jingshi 《Journal of Mountain Science》 SCIE CSCD 2009年第3期211-220,共10页
Because of the large number and remoteness, satellite data, including microwave data and optical imagery, have commonly been used in alpine glaciers surveys. Using remote sensing and Geographical Information System (... Because of the large number and remoteness, satellite data, including microwave data and optical imagery, have commonly been used in alpine glaciers surveys. Using remote sensing and Geographical Information System (GIS) techniques, the paper presents the results of a multitemporal satellite glacier extent mapping and glacier changes by glacier sizes in the Mt. Qomolangma region at the northern slopes of the middle Himalayas over the Tibetan Plateau. Glaciers in this region have both retreated and advanced in the past 35 years, with retreat dominating. The glacier retreat area was 3.23 km2 (or o.75 km^2 yr^-1 during 1974 and 1976, 8.68 km^2 (or 0.36 km^2 yr^-1 during 1976 and 1992, 1.44 km^2 (or 0.12 km^2 yr^-1) during 1992-2ooo. 1.14 km^2 (or 0.22 km^2 yr^-1 during 2000-2003, and 0.52 km^2 (or 0.07 km^2 yr^-1 during 2003-2008, respectively. While supra-glacier lakes on the debris-terminus of the Rongbuk Glacier were enlarged dramatically at the same time, from 0.05 km^2 in 1974 increased to 0.71 km^2 in 2008, which was more than 13 times larger in the last 35 years. In addition, glacier changes also showed spatial differences, for example, glacier retreat rate was the fastest at glacier termini between 5400 and 5700 m a.s.l than at other elevations. The result also shows that glaciers in the middle Himalayas retreat almost at a same pace with those in the western Himalayas. 展开更多
关键词 GLACIER lake Remote Sensing Mr. Qomolangma region HIMALAYAS Tibetan Plateau
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茶褐素对高脂喂养ApoE-/-小鼠主动脉粥样硬化作用及机制的研究 被引量:3
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作者 钟振威 卢青 丁世芳 《华南国防医学杂志》 CAS 2020年第3期151-155,共5页
目的探索茶褐素(theabrownin,TB)对高脂饲料喂养的载脂蛋白E基因敲除(ApoE-/-)小鼠主动脉粥样硬化的影响及可能机制。方法将40只4周龄雄性ApoE-/-小鼠随机分成对照组(n=10)、模型对照组(n=10)、他汀组(n=10)及TB组(n=10)。对照组给予普... 目的探索茶褐素(theabrownin,TB)对高脂饲料喂养的载脂蛋白E基因敲除(ApoE-/-)小鼠主动脉粥样硬化的影响及可能机制。方法将40只4周龄雄性ApoE-/-小鼠随机分成对照组(n=10)、模型对照组(n=10)、他汀组(n=10)及TB组(n=10)。对照组给予普通饲料喂养,其余3组给予高脂饲料喂养。12周后,对照组和模型对照组每天给予生理盐水(0.3 ml)灌胃、他汀组每天给予阿托伐他汀钙(10 mg/kg)灌胃,TB组每天给予TB(675 mg/kg)灌胃,按照原来条件继续饲养4周。16周后,检测血清总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)和低密度脂蛋白(low density lipoprotein,LDL)水平;苏木精-伊红(hematoxylin-eosin,HE)染色和大体油红O染色及测量主动脉斑块横断面积和表面积;免疫组织化学检测斑块内免疫细胞(巨噬细胞及T淋巴细胞)情况;实时荧光定量聚合酶链式反应(quantitative real-time polymerase chain reaction,qPCR)检测主动脉内白介素6(interleukin-6,IL-6)及巨噬细胞趋化因子1(monocyte chemoattractant protein-1,MCP-1)的表达水平。结果与对照组比较,模型对照组血脂水平、动脉粥样硬化(atherosclerosis,AS)斑块面积均增加,显示AS模型建立成功。与模型对照组相比,TB组TC、TG和LDL水平明显降低(P<0.05),斑块面积与主动脉管腔面积减少(P<0.05),斑块内免疫细胞浸润减轻(P<0.05),IL-6和MCP-1等炎性因子的表达水平下降(P<0.05)。与他汀组相比,TB组TC、TG和LDL水平、斑块面积、细胞浸润及炎症因子转录水平均未见明显差异(P>0.05)。结论TB能够减少高脂饮食小鼠主动脉粥样硬化斑块形成,其机制可能与血脂降低、粥样硬化斑块内炎症反应和免疫细胞水平降低有关。 展开更多
关键词 茶褐素 动脉粥样硬化 血脂 炎症反应 免疫细胞
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