FGD5 as a novel prognostic biomarker and its association with immune infiltrates in lung adenocarcinoma

Background:Non-small cell lung cancer(NSCLC)has a poor prognosis with a low 5-year survival rate.Lung adenocarcinoma(LUAD)accounts for 50%.Facio-genital dysplasia-5(FGD5),a member of a subfamily of Rho GTPGDP exchange factors,may be a good molecular biomarker for diagnosis and prognosis.Objective:To explore the clinical application of FGD5,the study was designed to investigate the prognosis value of FGD5 expression and its correlation with immune infiltrates in LUAD patients.Methods:Through the Wilcoxon signed-rank test and logistic regression,the correlation between clinical characteristics and FGD5 expression was analyzed.Kaplan-Meier plotter analysis,Cox regression,and a receiver operating characteristic(ROC)curve were constructed to evaluate the influence of FGD5 on prognosis.The function of FGD5 in lung cancer was analyzed using Gene set enrichment analysis(GSEA)and Single Sample Gene Set Enrichment Analysis(ssGSEA).Results:Compared to normal tissues,FGD5 was downregulated in LUAD.FGD5 may be a potential diagnostic and prognostic biomarker of lung cancer for its association with improved overall survival(OS),progression-free interval(PFI),and disease-specific survival(DSS)in LUAD.Results of functional analysis suggested that FGD5 was involved in the immune response for its association with immune infiltration.Conclusion:FGD5 may be a significant molecular biomarker for diagnosis and prognosis,presenting as an independent prognostic risk factor for LUAD.