Ankylosing spondylitis(AS)is a chronic progressive inflammatory immune disease,which mainly affects the spine and sacroiliac joints,with a high rate of late disability.At present,because the pathogenesis of the diseas...Ankylosing spondylitis(AS)is a chronic progressive inflammatory immune disease,which mainly affects the spine and sacroiliac joints,with a high rate of late disability.At present,because the pathogenesis of the disease is not clear,its treatment targets are not clear,and there is no consensus on intervention measures.Therefore,further exploration of the mechanism of the disease has certain guiding significance for clinical application.At the same time,non-coding RNA can regulate protein translation,participate in the physiological and pathological changes of AS,and is closely related to the progress of AS.Its internal mechanism and potential targets are worthy of in-depth study.This article summarizes the research progress of non-coding RNA involved in AS through the regulation of bone metabolism,inflammation,cell death and autophagy,in order to provide a theoretical basis for exploring potential clinical diagnostic markers and therapeutic targets of AS.展开更多
非特异性下腰痛(non-specific low back pain,NLBP)指排除已知疾病或病理变化所导致的腰骶部疼痛的疾病,由于患者的症状与实验室检查及影像学表现之间没有必然的关联性,临床探测不到确切的组织病理学结构改变以说明其病因,故称为“非特...非特异性下腰痛(non-specific low back pain,NLBP)指排除已知疾病或病理变化所导致的腰骶部疼痛的疾病,由于患者的症状与实验室检查及影像学表现之间没有必然的关联性,临床探测不到确切的组织病理学结构改变以说明其病因,故称为“非特异性下腰痛”[1]。其病程波动大,疗效不确切,费用高,对患者的生活及工作造成巨大负担[2]。治疗NLBP常用方法有运动、牵引、手法、针灸针刀、中药、理疗、微创手术等,中医理筋手法治疗NLBP有良好效果,现将近年来理筋手法治疗非特异性下腰痛研究相关文献综述如下。展开更多
基金National Natural Science Foundation Regional Fund Project(No.81660800)2021 Guangxi Famous Traditional Chinese Medicine Studio Construction Project。
文摘Ankylosing spondylitis(AS)is a chronic progressive inflammatory immune disease,which mainly affects the spine and sacroiliac joints,with a high rate of late disability.At present,because the pathogenesis of the disease is not clear,its treatment targets are not clear,and there is no consensus on intervention measures.Therefore,further exploration of the mechanism of the disease has certain guiding significance for clinical application.At the same time,non-coding RNA can regulate protein translation,participate in the physiological and pathological changes of AS,and is closely related to the progress of AS.Its internal mechanism and potential targets are worthy of in-depth study.This article summarizes the research progress of non-coding RNA involved in AS through the regulation of bone metabolism,inflammation,cell death and autophagy,in order to provide a theoretical basis for exploring potential clinical diagnostic markers and therapeutic targets of AS.
文摘非特异性下腰痛(non-specific low back pain,NLBP)指排除已知疾病或病理变化所导致的腰骶部疼痛的疾病,由于患者的症状与实验室检查及影像学表现之间没有必然的关联性,临床探测不到确切的组织病理学结构改变以说明其病因,故称为“非特异性下腰痛”[1]。其病程波动大,疗效不确切,费用高,对患者的生活及工作造成巨大负担[2]。治疗NLBP常用方法有运动、牵引、手法、针灸针刀、中药、理疗、微创手术等,中医理筋手法治疗NLBP有良好效果,现将近年来理筋手法治疗非特异性下腰痛研究相关文献综述如下。
