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Protective effect of heme oxygenase-1 on lung injury induced by erythrocyte instillation in rats 被引量:8
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作者 PANG Qing-feng zhou qiao-mei +3 位作者 ZENG Si DOU Li-dong JI Yong ZENG Yin-ming 《Chinese Medical Journal》 SCIE CAS CSCD 2008年第17期1688-1692,共5页
Background Intratracheal instillation of blood induces self-repaired acute lung injury. However, the mechanism of repair has been unclear. Heme-oxygenase (HO)-1, which catalyzes heme breakdown, acts as an inducible ... Background Intratracheal instillation of blood induces self-repaired acute lung injury. However, the mechanism of repair has been unclear. Heme-oxygenase (HO)-1, which catalyzes heme breakdown, acts as an inducible defense against oxidative stress and plays an important role in inflammation. The objective of this study was to test the role of HO-1 in lung injury caused by intratracheal instillation of red cells. Methods Forty healthy, male Sprague-Dawley rats were randomly divided into five groups: normal group, saline group, erythrocyte group, erythrocyte+zinc-protoporphyrin (ZnPP, HO-1 inhibitor) group and saline+ZnPP group. At 2 days after intratracheal instillation of red cells, lung tissues and lavage samples were isolated for biochemical determinations and histological measurements. Results Histological analysis revealed that administration of ZnPP worsened the acute lung injury induced by instilled erythrocytes. HO-1 was over-expressed in the erythrocyte group and in the erythrocyte + ZnPP group. Compared with the erythrocyte + ZnPP group, the levels of total protein, lactate dehydrogenase and tumor necrosis factor-a in the lavage were lower (P 〈0.01), while the level of interleukin-10 was higher in the erythrocyte group (P 〈0.01). Conclusion HO-1 protects against erythrocyte-induced inflammatory injury in lung. 展开更多
关键词 ERYTHROCYTE acute lung injury heine oxygenase-1
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