目的 探讨癌胚抗原(CEA),糖类抗原125(CA125)和糖类抗原19-9(CA19-9)对非小细胞肺癌(NSCLC)的早期筛查价值。方法 选择2005-2016年,在深圳市南山区所属的卫生机构进行1次以上肿瘤标记物检测的534例检查者为研究对象,包括NSCLC患者89例(...目的 探讨癌胚抗原(CEA),糖类抗原125(CA125)和糖类抗原19-9(CA19-9)对非小细胞肺癌(NSCLC)的早期筛查价值。方法 选择2005-2016年,在深圳市南山区所属的卫生机构进行1次以上肿瘤标记物检测的534例检查者为研究对象,包括NSCLC患者89例(病例组)及健康人群445例(对照组)。采用巢式病例对照研究的方法,比较NSCLC患者与健康人群在0~7年的随访期间CEA,CA125和CA199 等3种肿瘤标记物水平变化情况。结果 趋势性检验结果显示,越接近诊断时间,病例组血清CEA和CA19-9水平越高,确诊前0~1年与6~7年相比分别增加了57.03%( P <0.05)、41.75%( P< 0.05 ),而CA125水平无显著变化( P >0.05);对照组中CEA、CA19-9及CA125均未有显著变化趋势。病例组中CEA水平在临床诊断前2~3年显著高于对照组(1.56±0.899 ng/mL vs. 1.31±0.738 ng/mL, P <0.05),CA19-9水平在临床诊断前1~2年显著高于健康对照组(12.82±5.65 U/mL vs. 9.86±7.88 U/mL, P <0.05)。结论 血清CEA及CA19-9升高对早NSCLC的早期筛查具有重要的临床意义。展开更多
The research work has been seldom done about cloverleaf junction expression in a 3-dimensional city model (3DCM). The main reason is that the cloverleaf junction is often in a complex and enormous construction. Its ma...The research work has been seldom done about cloverleaf junction expression in a 3-dimensional city model (3DCM). The main reason is that the cloverleaf junction is often in a complex and enormous construction. Its main body is bestraddle in air,and has aerial intersections between its parts. This complex feature made cloverleaf junction quite different from buildings and terrain, therefore, it is difficult to express this kind of spatial objects in the same way as for buildings and terrain. In this paper,authors analyze spatial characteristics of cloverleaf junction, propose an all-constraint points TIN algorithm to partition cloverleaf junction road surface, and develop a method to visualize cloverleaf junction road surface using TIN. In order to manage cloverleaf junction data efficiently, the authors also analyzed the mechanism of 3DCM data management, extended BLOB type in relational database, and combined R-tree index to manage 3D spatial data. Based on this extension, an appropriate data展开更多
文摘目的 探讨癌胚抗原(CEA),糖类抗原125(CA125)和糖类抗原19-9(CA19-9)对非小细胞肺癌(NSCLC)的早期筛查价值。方法 选择2005-2016年,在深圳市南山区所属的卫生机构进行1次以上肿瘤标记物检测的534例检查者为研究对象,包括NSCLC患者89例(病例组)及健康人群445例(对照组)。采用巢式病例对照研究的方法,比较NSCLC患者与健康人群在0~7年的随访期间CEA,CA125和CA199 等3种肿瘤标记物水平变化情况。结果 趋势性检验结果显示,越接近诊断时间,病例组血清CEA和CA19-9水平越高,确诊前0~1年与6~7年相比分别增加了57.03%( P <0.05)、41.75%( P< 0.05 ),而CA125水平无显著变化( P >0.05);对照组中CEA、CA19-9及CA125均未有显著变化趋势。病例组中CEA水平在临床诊断前2~3年显著高于对照组(1.56±0.899 ng/mL vs. 1.31±0.738 ng/mL, P <0.05),CA19-9水平在临床诊断前1~2年显著高于健康对照组(12.82±5.65 U/mL vs. 9.86±7.88 U/mL, P <0.05)。结论 血清CEA及CA19-9升高对早NSCLC的早期筛查具有重要的临床意义。
文摘在野外地质调查的基础上,对下扬子巢湖地区二叠系栖霞组硅质结核地球化学特征进行了系统的分析。结果表明:下扬子巢湖地区二叠系栖霞组硅质结核核w(SiO 2)为73.50%~96.95%(平均值为85.84%),其他元素含量较低。在主量元素的判别上,硅质成因为生物质成因;在Ti/V-V/Y判别图解中,巢湖地区栖霞组硅质结核来源于洋中脊与大洋盆地端元区域;在元素氧化还原关系上,硅质结核显示出有氧、贫氧与厌氧混合状态;在稀土元素配分图解中,显示出中稀土元素富集,稀土元素总量与P 2 O 5具有很好的相关性和Ce的负异常。在此基础上,结合二叠纪全球气候与海陆位置及洋流的关系,认为下扬子巢湖地区二叠系栖霞组硅质结核是在二叠纪全球气候转变的背景下,在洋流的作用下,来源于大洋中脊与大洋盆地的硅质被大陆边缘的硅质生物捕获而形成硅质结核,洋流作用在硅质结核的形成上起到关键作用。
文摘The research work has been seldom done about cloverleaf junction expression in a 3-dimensional city model (3DCM). The main reason is that the cloverleaf junction is often in a complex and enormous construction. Its main body is bestraddle in air,and has aerial intersections between its parts. This complex feature made cloverleaf junction quite different from buildings and terrain, therefore, it is difficult to express this kind of spatial objects in the same way as for buildings and terrain. In this paper,authors analyze spatial characteristics of cloverleaf junction, propose an all-constraint points TIN algorithm to partition cloverleaf junction road surface, and develop a method to visualize cloverleaf junction road surface using TIN. In order to manage cloverleaf junction data efficiently, the authors also analyzed the mechanism of 3DCM data management, extended BLOB type in relational database, and combined R-tree index to manage 3D spatial data. Based on this extension, an appropriate data
