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基于微信小程序的疼痛药物剂量设置工具研发与应用
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作者 蒋珺 季晶晶 +4 位作者 龚黎燕 韩帅 周琴飞 俞新燕 丁群芳 《医院管理论坛》 2024年第2期92-96,74,共6页
目的研发关于疼痛药物剂量设置微信小程序,并测试其可用性。目的2020年1-2月,根据临床需求组建团队研发。3-4月,采用方便抽样法行预实验,选取某三甲医院的医生和护士各20名,分别使用该小程序和传统计算器进行不同阿片类药物的剂量转换(... 目的研发关于疼痛药物剂量设置微信小程序,并测试其可用性。目的2020年1-2月,根据临床需求组建团队研发。3-4月,采用方便抽样法行预实验,选取某三甲医院的医生和护士各20名,分别使用该小程序和传统计算器进行不同阿片类药物的剂量转换(医生)及患者自控镇痛泵的药物参数设置(护士)各400次,比较所需时间及正确性,并采用易用性量表(USE)评价小程序。目的医生、护士运用小程序计算的准确率为100%,均高于传统方法(p<0.01);计算所需时间均快于传统方法(p<0.01);医生和护士USE量表的平均得分分别为6.56±0.20分、6.60±0.19分。目的研发的小程序为医生转换疼痛药物剂量提供参考,满足护士对镇痛泵参数的准确计算和设置的需求,医护人员的接受度较高,可用性好。 展开更多
关键词 癌痛 患者自控镇痛 用药安全 微信小程序
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Methionine Levels in the Diet for Pregnant Female Rabbits Affects Hair Follicles Development of Baby Rabbits 被引量:1
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作者 zhou qin-fei TAO Ke +2 位作者 WANG Yong-cai XIAO Wen-chuan WANG Wei-lin 《Animal Husbandry and Feed Science》 CAS 2012年第5期193-196,共4页
[ Objective] This experiment was conducted to study methionine level in diet for prepnant famale rabbits on the development of hair follicles of baby rabbits. [ Method] Fifty-four Angora female rabbits with similar bo... [ Objective] This experiment was conducted to study methionine level in diet for prepnant famale rabbits on the development of hair follicles of baby rabbits. [ Method] Fifty-four Angora female rabbits with similar body weight, parities and historicaly hair yield were randomly assigned to three groups with eighteen replicates in each group and one rabbit per replicate. Rabbits during pregnancy were fed diets with 0.5!%, 0.71% and 0.91% methionine, respectively. Hair follicle density and diameter in the back skin were determined at 18-day fetus. 26-day fetus, newborn and 2- month-old,and hair fiber diameter at 2-month-old was also determined. [ Result] The results showed as follows: (1) hair follicle density and diameter at each stage,coarse hair fiber diameter at 2-month. old showed a tendency of increasing with dietary methionine level( P 〉0.05), fine hair diameter in 0.91% group was significantly larger than that in 0.51% group at 2-month-old ( P 〈 0.05). (2) With the development of baby rabbit,the ratio of secondary follicle and primary follicle increased gradually, at newborn of rabbits in group 0.51%, 0.71% and 0.91%were 5.84, 5.56 and 5.81, respectively, and at 2-month-old were 8.47, 7.97 and 8.03, respectively. (3) Baby rabbits in group 0.51%, 0.71% and 0.91% gained increases of primary follicle diameter by 0.58, 0.57 and 0.61pm/d from 26-day fetus to birth, and 0.11,0.11 and 0.12 prn/d from birth to 2-month-old, re- spectively; they also gained increases on secondary follicle diameter by 0.0018,0. 012 and 0. 011prn/d from birth to 2-months-old, respectively. [ Conclusion] These results indicate that increase of methionine level in diet for female rabbits during pregnancy is a stimulation factor for the development of hair follicle of baby rabbits, and can improve their hair fiber diameter. 展开更多
关键词 Female rabbits Baby rabbits METHIONINE Hair follicle development
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β-榄香烯对骨癌痛大鼠吗啡耐受的影响及作用机制研究 被引量:3
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作者 周琴飞 龚黎燕 +2 位作者 鲍关爱 丁群芳 季晶晶 《中草药》 CAS CSCD 北大核心 2022年第10期3070-3077,共8页
目的研究β-榄香烯对骨癌痛大鼠吗啡耐受的影响及作用机制。方法雄性Wistar大鼠随机分为对照组、吗啡组及β-榄香烯低、高剂量(0.7、2.8 mg/kg)组和艾芬地尔(5 mg/kg)组,每组15只;对照组予以生理盐水胫骨注射并ip二甲基亚砜,其余各组构... 目的研究β-榄香烯对骨癌痛大鼠吗啡耐受的影响及作用机制。方法雄性Wistar大鼠随机分为对照组、吗啡组及β-榄香烯低、高剂量(0.7、2.8 mg/kg)组和艾芬地尔(5 mg/kg)组,每组15只;对照组予以生理盐水胫骨注射并ip二甲基亚砜,其余各组构建骨癌痛-慢性吗啡耐受模型后,分别ip相应药物,通过检测机械撤退阈值和热退潜伏期对各组大鼠进行疼痛行为学评估;采用qRT-PCR检测各组大鼠脊髓组织肿瘤坏死因子(tumor necrosis factor-α,TNF-α)、白细胞介素-1β(interleukin-1β,IL-1β)、IL-6、μ阿片受体(μopioid receptor,MOPR)、N-甲基-D-门冬氨酸受体亚单位2B(N-methyl-D-asparate receptor subunit 2B,NR2B)和环磷酸腺苷(cyclic adenosine monophosphate,cAMP)的mRNA表达;采用Western blotting检测各组大鼠脊髓组织NR2B、cAMP和MOPR的蛋白表达。分别采用不同质量浓度(5、10、20、25µg/mL)的β-榄香烯处理人神经母细胞瘤SH-SY5Y细胞,采用CCK-8法检测SH-SY5Y细胞活性,采用试剂盒测定细胞内cAMP含量,确定β-榄香烯作用于SH-SY5Y细胞的适宜质量浓度;设置对照组、吗啡组、β-榄香烯(5µg/mL)组和艾芬地尔(10µmol/L)组,对照组予以常规培养,其余各组采用10µmol/L吗啡作用SH-SY5Y细胞48 h,以构建吗啡耐受细胞模型,而后β-榄香烯组和艾芬地尔组分别给予相应药物,采用qRT-PCR检测TNF-α、IL-1β、IL-6、NR2B、cAMP和MOPR的mRNA表达,采用Western blotting检测NR2B、cAMP和MOPR的蛋白表达。结果给药第1天,相较于对照组,其余各组大鼠机械撤退阈值和热退潜伏期明显升高(P<0.001),随给药时间延长,吗啡组机械撤退阈值和热退潜伏期逐渐下降,各给药组机械撤退阈值和热退潜伏期明显高于吗啡组(P<0.05、0.01、0.001)。β-榄香烯显著抑制SH-SY5Y细胞活性(P<0.001),且呈剂量和时间相关性;β-榄香烯对SH-SY5Y细胞内cAMP含量无明显影响。吗啡耐受可促进大鼠脊髓组织和SH-SY5Y细胞中TNF-α、IL-1β、IL-6、NR2B及cAMP表达(P<0.001),抑制MOPR表达(P<0.001);给予艾芬地尔或β-榄香烯后,则呈现相反趋势(P<0.01、0.001),且β-榄香烯的作用呈剂量相关性。结论β-榄香烯具有一定的镇痛作用,可通过调控MOPR/NR2B有效缓解骨癌痛大鼠吗啡耐受。 展开更多
关键词 Β-榄香烯 骨癌痛 吗啡耐受 μ阿片受体/N-甲基-D-门冬氨酸受体亚单位2B 炎症因子
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