目的:探讨简化的高分辨率双参数MRI(HR-T2WI/DWI)扫描协议在评估宫颈癌盆腔淋巴结转移的可行性。方法:前瞻性纳入宫颈癌患者110例,术前均行HR-T2WI/DWI和常规多参数MRI(mp-MRI)检查,其中HR-T2WI/DWI扫描时长为6 min 26 s,mp-MRI扫描时长...目的:探讨简化的高分辨率双参数MRI(HR-T2WI/DWI)扫描协议在评估宫颈癌盆腔淋巴结转移的可行性。方法:前瞻性纳入宫颈癌患者110例,术前均行HR-T2WI/DWI和常规多参数MRI(mp-MRI)检查,其中HR-T2WI/DWI扫描时长为6 min 26 s,mp-MRI扫描时长为14 min 57 s。以术后病理为标准,由两名影像科医师利用两种扫描协议的图像对盆腔淋巴结转移的一致性进行分析,同时使用ROC曲线分析两种扫描协议判定宫颈癌盆腔淋巴结转移的诊断效能。结果:110例宫颈癌患者中术后病理证实盆腔淋巴结转移31例,非转移79例。两名医师用HR-T2WI/DWI和mp-MRI评估时Kappa系数分别为0.800、0.812,具有良好的一致性。ROC曲线显示用HR-T2WI/DWI和mp-MRI在诊断宫颈癌盆腔淋巴结转移时曲线下面积(AUC)值分别为0.836、0.885,两种方法诊断效能的差异无统计学意义(Z=1.491,P=0.135)。结论:HR-T2WI/DWI在诊断宫颈癌盆腔淋巴结转移的一致性和效能与常规mp-MRI协议相当,且其扫描时间明显缩短,可以常规应用于临床。展开更多
Continental epithermal ore deposits are commonly associated with sedimentary organic matter,oils or solid bitumen.These organics embedded in mineral deposits can convey valuable information of the ore genesis.However,...Continental epithermal ore deposits are commonly associated with sedimentary organic matter,oils or solid bitumen.These organics embedded in mineral deposits can convey valuable information of the ore genesis.However,the extent to which the formation of ore minerals was recorded by organic compounds remains largely unknown,as also is how metal-rich ores interfere with the molecular proxies in the temperature regime envisaged for hydrothermal activity.The molecular compositional changes of various polycyclic aromatic steranes and polycyclic aromatic hydrocarbons and compounds derived from the Jinding Pb/Zn deposit,SW China provide new data.Aliphatic regular steranes are present as traces.The transformation from polycyclic aromatic steranes to unsubstituted polycyclic aromatic hydrocarbons is observed to show an increased trend with increasing hydrothermal alteration levels;this is consistent with the transformation from unsubstituted polycyclic aromatic hydrocarbons to heterocyclic compounds.Dehydrocyclization(aromatization)of polycyclic biological compounds and hydrodecyclization(dearomatization)of polycyclic aromatic compounds are two important reaction pathways in hydrothermal systems with moderate temperature.This detailed investigation of organicinorganic interactions of two groups of polycyclic compounds with metal-rich ores provides insights into the questions on how and to what extent the formation of Pb/Zn deposits can be recorded by organics.This work will improve our understanding of carbon reduction,oxidation or condensation in the deep Earth and the carbon exchange between the Earth's crust and mantle,and may shed light on the processes for ultra-deep hydrocarbon exploration.展开更多
文摘目的:探讨简化的高分辨率双参数MRI(HR-T2WI/DWI)扫描协议在评估宫颈癌盆腔淋巴结转移的可行性。方法:前瞻性纳入宫颈癌患者110例,术前均行HR-T2WI/DWI和常规多参数MRI(mp-MRI)检查,其中HR-T2WI/DWI扫描时长为6 min 26 s,mp-MRI扫描时长为14 min 57 s。以术后病理为标准,由两名影像科医师利用两种扫描协议的图像对盆腔淋巴结转移的一致性进行分析,同时使用ROC曲线分析两种扫描协议判定宫颈癌盆腔淋巴结转移的诊断效能。结果:110例宫颈癌患者中术后病理证实盆腔淋巴结转移31例,非转移79例。两名医师用HR-T2WI/DWI和mp-MRI评估时Kappa系数分别为0.800、0.812,具有良好的一致性。ROC曲线显示用HR-T2WI/DWI和mp-MRI在诊断宫颈癌盆腔淋巴结转移时曲线下面积(AUC)值分别为0.836、0.885,两种方法诊断效能的差异无统计学意义(Z=1.491,P=0.135)。结论:HR-T2WI/DWI在诊断宫颈癌盆腔淋巴结转移的一致性和效能与常规mp-MRI协议相当,且其扫描时间明显缩短,可以常规应用于临床。
基金financially supported by the National Key Research and Development Program of China(Grant No.2019YFA0708504)National Natural Science Foundation of China(Grant Nos.U20B6001,42141021,42102185)。
文摘Continental epithermal ore deposits are commonly associated with sedimentary organic matter,oils or solid bitumen.These organics embedded in mineral deposits can convey valuable information of the ore genesis.However,the extent to which the formation of ore minerals was recorded by organic compounds remains largely unknown,as also is how metal-rich ores interfere with the molecular proxies in the temperature regime envisaged for hydrothermal activity.The molecular compositional changes of various polycyclic aromatic steranes and polycyclic aromatic hydrocarbons and compounds derived from the Jinding Pb/Zn deposit,SW China provide new data.Aliphatic regular steranes are present as traces.The transformation from polycyclic aromatic steranes to unsubstituted polycyclic aromatic hydrocarbons is observed to show an increased trend with increasing hydrothermal alteration levels;this is consistent with the transformation from unsubstituted polycyclic aromatic hydrocarbons to heterocyclic compounds.Dehydrocyclization(aromatization)of polycyclic biological compounds and hydrodecyclization(dearomatization)of polycyclic aromatic compounds are two important reaction pathways in hydrothermal systems with moderate temperature.This detailed investigation of organicinorganic interactions of two groups of polycyclic compounds with metal-rich ores provides insights into the questions on how and to what extent the formation of Pb/Zn deposits can be recorded by organics.This work will improve our understanding of carbon reduction,oxidation or condensation in the deep Earth and the carbon exchange between the Earth's crust and mantle,and may shed light on the processes for ultra-deep hydrocarbon exploration.
