Protons are emitted much more affluently in neutron-deficient system ^(40)Ar+^(112)Sn while triton emissions are greater in a neutron-rich system ^(40)Ar+^(124)Sn at incident energy of 30 MeV/u.Similar to neutron,prot...Protons are emitted much more affluently in neutron-deficient system ^(40)Ar+^(112)Sn while triton emissions are greater in a neutron-rich system ^(40)Ar+^(124)Sn at incident energy of 30 MeV/u.Similar to neutron,proton emission provied a dominant contribution to neutralize the system N/Z in the decay process of the hot nuclei.The emission of hydrogen isotopes with high energies is much enhanced in the ^(112)Sn system.The original temperature of the hot nuclei in the ^(40)Ar+^(112)Sn reaction is 5.8±0.3 MeV,about 0.7 MeV higher than 5.1±0.3 MeV as in the ^(40)Ar+^(124)Sn reaction.展开更多
文摘目的:探讨牛磺酸上调基因1(TUG1)在肝纤维化中的作用机制。方法:按照文献建立TGF-β1(5 ng/ml)刺激的活化肝星状细胞模型和经典的1%DMN(1 ml/kg/d)致大鼠肝纤维化模型,将肝纤维化大鼠和活化肝星状细胞(HSC)均分为模型对照组、阴性对照组(沉默TUG1阴性对照)、siRNA干扰组(TUG1基因沉默组)。实验结束后利用苏木精-伊红(HE)染色检测大鼠肝脏组织病理变化;采用逆转录-聚合酶链反应(RT-PCR)法、蛋白免疫印记(Western blot)分别测定大鼠肝组织及活化肝星状细胞中α-平滑肌肌动蛋白(α-SMA)、TUG1、I型胶原蛋白(collagenI)、基质金属蛋白酶-2(MMP-2)、金属蛋白酶组织抑制因子(TIMP-1)、Smad2、Smad3表达水平。结果:肝组织病理学检查显示,沉默TUG1能够明显缓解肝脏纤维化病理改变,Western blot结果显示,沉默TUG1能够显著降低大鼠肝组织和活化肝星状细胞中TUG1、α-SMA、collagenI、MMP-2、TIMP-1、Smad2、Smad3基因与蛋白表达水平(P<0.05)。与模型对照组相比,阴性对照组的TUG1、α-SMA的蛋白与基因水平明显升高(P<0.05)。与模型对照组和阴性对照组相比,siRNA干扰组中TUG1,α-SMA,collagenI,MMP-2,TIMP-1,Smad2 and Smad3的蛋白和基因水平显著降低(P<0.05),而在模型对照组和阴性对照组中TUG1,α-SMA,collagenI,MMP-2,TIMP-1,Smad2 and Smad3的蛋白和基因表达水平之间差异无显著性。结论:TUG1在肝纤维化组织和活化的肝星状细胞中显著上调,沉默TUG1可能通过抑制转化生长因子-β1(TGF-β1)/Smad信号通路改善1%DMN致大鼠肝纤维化病理损伤,降低活化肝星状细胞中纤维化相关蛋白水平,发挥抗肝纤维化的作用。
基金Supported by the One Hundred Talents Project and Major Subjects of the Chinese Academy of Sciences under Grant No.KJ95T-03。
文摘Protons are emitted much more affluently in neutron-deficient system ^(40)Ar+^(112)Sn while triton emissions are greater in a neutron-rich system ^(40)Ar+^(124)Sn at incident energy of 30 MeV/u.Similar to neutron,proton emission provied a dominant contribution to neutralize the system N/Z in the decay process of the hot nuclei.The emission of hydrogen isotopes with high energies is much enhanced in the ^(112)Sn system.The original temperature of the hot nuclei in the ^(40)Ar+^(112)Sn reaction is 5.8±0.3 MeV,about 0.7 MeV higher than 5.1±0.3 MeV as in the ^(40)Ar+^(124)Sn reaction.