SuperView-I satellite constellation (SuperView-I for short) is the first commercial remote sensing constellation with a resolution down to 0.5 m. It's an important part of the national spatial information infrastru...SuperView-I satellite constellation (SuperView-I for short) is the first commercial remote sensing constellation with a resolution down to 0.5 m. It's an important part of the national spatial information infrastructure construction. It will play an important role for the global users providing remote sensing data, application solutions and remote sensing value-added services with its highresolution and 24-hour observation capability. At present, 4 satellites of the constellation have been successfully launched and networked on orbit. The services cover surveying and mapping, land resource surveying, urban planning, agriculture, forestry, water conservancy, geological mining, environmental monitoring, defense, disaster reduction along with other traditional industries. There are also great potential applications in Mobile Intemet, LBS, Smart city, insurance and other emerging professions. The successful operation of SuperView-I breaks the overseas monopoly for commercial high-resolution remote sensing satellite imagery in the China market. It's one of the major achievements in China space science and technology by actively exploring the development of commercial remote sensing markets, which is of strategic significance to the development of China remote sensing satellite business.展开更多
文摘SuperView-I satellite constellation (SuperView-I for short) is the first commercial remote sensing constellation with a resolution down to 0.5 m. It's an important part of the national spatial information infrastructure construction. It will play an important role for the global users providing remote sensing data, application solutions and remote sensing value-added services with its highresolution and 24-hour observation capability. At present, 4 satellites of the constellation have been successfully launched and networked on orbit. The services cover surveying and mapping, land resource surveying, urban planning, agriculture, forestry, water conservancy, geological mining, environmental monitoring, defense, disaster reduction along with other traditional industries. There are also great potential applications in Mobile Intemet, LBS, Smart city, insurance and other emerging professions. The successful operation of SuperView-I breaks the overseas monopoly for commercial high-resolution remote sensing satellite imagery in the China market. It's one of the major achievements in China space science and technology by actively exploring the development of commercial remote sensing markets, which is of strategic significance to the development of China remote sensing satellite business.
文摘SHP2 (Src homology 2 domain-containing protein tyrosine phosphatase-2)是由Ptpn11基因编码的非受体型蛋白酪氨酸磷酸酶,通过RAS (rat sarcoma)-ERK (extracellular regulated protein kinases)信号通路的活化调控细胞生长、分化和凋亡,并参与PD-1 (programmed cell death protein 1)/PD-L1(programmed cell death ligand 1)通路的免疫监控,已成为有突破意义的抗癌药物新靶标.靶向SHP2变构位点的抑制剂通过稳定SHP2非活性构象而抑制磷酸酶催化功能,具有很好的成药性.但是,SHP2功能获得性突变(gainoffunction,简称GOF)导致一系列发育障碍疾病和肿瘤的发生,并对SHP2野生型变构抑制剂产生耐药性.本工作首次以靶向SHP2激活突变体的变构抑制剂为靶头,基于PROTACs(proteolysis-targeting chimeras)技术,设计合成了一系列全新SHP2小分子降解剂.其中先导化合物3f和4d保持了对突变型SHP2^(E76A)的酶抑制活性,而且对于野生型SHP2依赖的人食管鳞癌细胞KYSE-520和突变型SHP2^(N58S)人大细胞肺癌细胞NCI-H661都显示强效抗增殖活性,比相应变构抑制剂的活性提高了5~10倍,为治疗SHP2突变或活化导致的遗传性疾病或肿瘤提供了新的干预策略.