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支气管双相反应性试验提高哮喘诊断率的作用
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作者 朱礼星 支明俊 +3 位作者 周雁苹 叶思环 罗琼伊 缪远婷 《大医生》 2018年第11期13-14,共2页
目的观察支气管双相反应性试验对提高哮喘诊断率的作用。方法选取本院呼吸科收治的398例疑似支气管哮喘患者作为研究对象,通过整合支气管激发试验或支气管舒张试验的两者优点,构建支气管双相反应性试验,依据支气管双相反应性试验(激发/... 目的观察支气管双相反应性试验对提高哮喘诊断率的作用。方法选取本院呼吸科收治的398例疑似支气管哮喘患者作为研究对象,通过整合支气管激发试验或支气管舒张试验的两者优点,构建支气管双相反应性试验,依据支气管双相反应性试验(激发/舒张试验)结果,将患者分为A、B、C、D 4种类别。对C组患者(激发-/舒张+)20例,D组患者(激发-/舒张-)119例随访3年,观察两组病例3年内发展成典型支气管哮喘的概率差异。结果 3年的观察期结束后,C组患者(激发-/舒张+)的确诊哮喘的发病率为73.68%,D组(激发-/舒张-)为5.40%。两组比较,差异具有显著性意义(P <0.05)。结论支气管双相反应性试验在支气管哮喘的诊断方面能提供比支气管单相反应试验(支气管激发试验或支气管舒张试验)更多的有益信息。激发-/舒张+病例(C组病例)有可能成为哮喘的诊断依据之一。激发-/舒张-病例(D组病例)可以作为支气管哮喘的排外依据。支气管双相反应性试验有助于提高支气管哮喘的诊断率,减少漏诊的概率。 展开更多
关键词 支气管哮喘 支气管双相反应性试验 诊断率
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微通道换热器在湿工况下的性能研究 被引量:1
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作者 王冠军 王炎峰 +1 位作者 朱丽星 吴振鑫 《暖通空调》 2022年第11期138-141,共4页
对微通道换热器在湿工况下的换热性能和百叶窗翅片间冷凝水的排除进行了试验研究,分析了不同风速下微通道蒸发器的性能差异及结露对换热性能的影响。结果表明:换热量随着风速的增大而增大,扁管越宽换热量越大,但随着扁管宽度增大换热量... 对微通道换热器在湿工况下的换热性能和百叶窗翅片间冷凝水的排除进行了试验研究,分析了不同风速下微通道蒸发器的性能差异及结露对换热性能的影响。结果表明:换热量随着风速的增大而增大,扁管越宽换热量越大,但随着扁管宽度增大换热量增大的优势逐渐减弱;制冷剂分液是微通道蒸发器设计的关键,对蒸发器的传热与流动性具有很大的影响,且对安装角度较敏感;蒸发器空气侧翅片间的冷凝水难排除是影响蒸发器性能的主要原因,均匀的制冷剂分配对冷凝水的排水更有益。 展开更多
关键词 微通道 换热器 湿工况 换热量 蒸发器:冷凝水排除 制冷剂
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脉搏指示连续心排血量法测定婴幼儿心内直视围手术期血流动力学变化的临床意义 被引量:1
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作者 范佳杰 谈林华 +9 位作者 舒强 杜立中 施珊珊 胡蕾 张彩云 朱力行 张泽伟 李建华 朱雄凯 俞建根 《中华临床医师杂志(电子版)》 CAS 2012年第22期7118-7125,共8页
目的临床应用脉搏指示连续心排血量法(PiCCO),初步研究和探索婴幼儿三种常见先天性心脏病(简称先心病)[室间隔缺损(VSD)、室间隔缺损合并肺动脉高压(PH)、法洛四联症(TOF)]患者围手术期心排血量、血管内容量、血管外肺水、肺血管通透性... 目的临床应用脉搏指示连续心排血量法(PiCCO),初步研究和探索婴幼儿三种常见先天性心脏病(简称先心病)[室间隔缺损(VSD)、室间隔缺损合并肺动脉高压(PH)、法洛四联症(TOF)]患者围手术期心排血量、血管内容量、血管外肺水、肺血管通透性等血流动力学参数,为进一步提高危重先心病的手术成功率提供更为客观、直接的依据。方法前瞻性连续选取浙江大学附属儿童医院2010年8月至2011年6月经体外循环心内直视根治手术的0~3岁先心病患儿30例为研究对象。其中TOF10例,VSD10例,VSD+PH10例。连续测定和记录所有患儿术后0h、4h、8h、12h、24h、48h、72h的血流动力学变化,包括心指数(CI)、全心舒张末期容积指数(GEDVI)、血管外肺水指数(EVLWI)、肺血管通透性指数(PVPI)等。抽血检测术前、术后4h、24h、48h、72h的血浆CK-MB活性、CK-MB质量、肌钙蛋白水平,同时监测和记录左心房压(LAP)、中心静脉压(CVP)、平均肺动脉压(mPAP)、肺血管阻力指数(PVRI)、血管活性药评分、血乳酸和PaO2/FiO2。结果 (1)30例患儿中男18例,女12例,VSD、VSD+PH、TOF患者各10例,均顺利出院。(2)三组患者围手术期CK-MB活性、CK-MB质量、肌钙蛋白均于CPB术后4h达到最高值,后逐渐下降恢复。(3)三组患者术后8~12hCI相对最低,但与术后0h比较无统计学差异,VSD+PH组和TOF组术后48hCI值均较术后0h显著上升(P<0.05)。TOF组患者在术后各时点的CI均低于VSD组(P<0.05)和VSD+PH组(P<0.05)。(4)所有3组患者术后各时点的mPAP和PVRI与术前比较均无统计学差异;组间比较显示VSD+PH组患者术前和术后的mPAP和PVRI均显著高于VSD组和TOF组同时点的水平(P<0.05)。(5)TOF组、VSD+PH组患者术后早期GEDVI均显著低于VSD组(P<0.05)。与术后0h相比,VSD组患者术后12h的GEDVI显著增加恢复(P<0.05),TOF组术后24h的GEDVI开始显著增加(P<0.05),VSD+PH组患者GEDVI于术后48h显著增加恢复(P<0.05)。(6)组间比较显示术后48h时,VSD+PH组EVLWI显著高于TOF组(P<0.05),而TOF组EVLWI显著高于VSD组(P<0.05);VSD组术后24h和48h的PVPI显著低于VSD+PH组和TOF组(P<0.05)。结论微创的PiCCO法揭示了三种先心病心内直视根治术后的详细的血流动力学特征,包括CI、GEDVI、EVLW、SVRI、PVRI等参数,具有指导临床正确判断和有效治疗的意义。 展开更多
关键词 心脏缺损 先天性 婴儿 血流动力学 脉搏指示连续心排血量法
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Varying coefficient analysis for indeterminate species interactions with non-parametric estimation, exemplifying with a fig-fig wasp system 被引量:9
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作者 SHI Lei WANG RuiWu +3 位作者 zhu lixing ZEN WeiMing XU WangLi ZHENG Qi 《Chinese Science Bulletin》 SCIE EI CAS 2011年第24期2545-2552,共8页
Research on species interactions has generally assumed that species have a fixed interaction and therefore linear or non-linear parametric regression models (e.g. exponential, logistic) have been widely used to descri... Research on species interactions has generally assumed that species have a fixed interaction and therefore linear or non-linear parametric regression models (e.g. exponential, logistic) have been widely used to describe the species interaction. However, these models that describe the relationship between interacting species as a specific functional response might not be appropriate for real biological communities, for instance, in a chaotic system, when the species relationship varies among different situations. To allow a more accurate description of the relationship, we developed a species correlation model with varying coefficient analysis, in which a non-parametric estimation is applied to identify, as a function of related factors, variation in the correlation coefficient. This was applied to a fig-fig wasp model system. When the effect of the factors on the relationship can be described with parameters, the new method reduces to traditional parametric correlation analysis. In this way, the new method is more general and flexible for empirical data analyses, but different by allowing investigation of whether a species interaction varies with respect to factors, and of the factors that maintain or change the species interaction. This method will have important applications in both theoretical and applied research (e.g. epidemiology, community management). 展开更多
关键词 相互作用系数 非参数估计 混沌系统 无花果 物种 非线性参数 例证 小蜂
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Shrinkage estimation analysis of correlated binary data with a diverging number of parameters 被引量:2
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作者 XU PeiRong FU WenJiang zhu lixing 《Science China Mathematics》 SCIE 2013年第2期359-377,共19页
For analyzing correlated binary data with high-dimensional covariates,we,in this paper,propose a two-stage shrinkage approach.First,we construct a weighted least-squares(WLS) type function using a special weighting sc... For analyzing correlated binary data with high-dimensional covariates,we,in this paper,propose a two-stage shrinkage approach.First,we construct a weighted least-squares(WLS) type function using a special weighting scheme on the non-conservative vector field of the generalized estimating equations(GEE) model.Second,we define a penalized WLS in the spirit of the adaptive LASSO for simultaneous variable selection and parameter estimation.The proposed procedure enjoys the oracle properties in high-dimensional framework where the number of parameters grows to infinity with the number of clusters.Moreover,we prove the consistency of the sandwich formula of the covariance matrix even when the working correlation matrix is misspecified.For the selection of tuning parameter,we develop a consistent penalized quadratic form(PQF) function criterion.The performance of the proposed method is assessed through a comparison with the existing methods and through an application to a crossover trial in a pain relief study. 展开更多
关键词 correlated binary data variable selection diverging number of parameters adaptive LASSO GEE oracle properties sandwich covariance formula penalized quadratic form function
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Stable direction recovery in single-index models with a diverging number of predictors
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作者 zhu LiPing zhu lixing 《Science China Mathematics》 SCIE 2010年第7期1814-1823,共10页
Large dimensional predictors are often introduced in regressions to attenuate the possible modeling bias. We consider the stable direction recovery in single-index models in which we solely assume the response Y is in... Large dimensional predictors are often introduced in regressions to attenuate the possible modeling bias. We consider the stable direction recovery in single-index models in which we solely assume the response Y is independent of the diverging dimensional predictors X when βτ 0 X is given, where β 0 is a p n × 1 vector, and p n →∞ as the sample size n →∞. We first explore sufficient conditions under which the least squares estimation β n0 recovers the direction β 0 consistently even when p n = o(√ n). To enhance the model interpretability by excluding irrelevant predictors in regressions, we suggest an e1-regularization algorithm with a quadratic constraint on magnitude of least squares residuals to search for a sparse estimation of β 0 . Not only can the solution β n of e1-regularization recover β 0 consistently, it also produces sufficiently sparse estimators which enable us to select "important" predictors to facilitate the model interpretation while maintaining the prediction accuracy. Further analysis by simulations and an application to the car price data suggest that our proposed estimation procedures have good finite-sample performance and are computationally efficient. 展开更多
关键词 E1 -minimization diverging parameters inverse regression RESTRICTED orthonormality SPARSITY SUFFICIENT dimension reduction
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Empirical likelihood-based evaluations of Value at Risk models
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作者 WEI ZhengHong WEN SongQiao zhu lixing 《Science China Mathematics》 SCIE 2009年第9期1995-2006,共12页
Value at Risk (VaR) is a basic and very useful tool in measuring market risks. Numerous VaR models have been proposed in literature. Therefore, it is of great interest to evaluate the efficiency of these models, and t... Value at Risk (VaR) is a basic and very useful tool in measuring market risks. Numerous VaR models have been proposed in literature. Therefore, it is of great interest to evaluate the efficiency of these models, and to select the most appropriate one. In this paper, we shall propose to use the empirical likelihood approach to evaluate these models. Simulation results and real life examples show that the empirical likelihood method is more powerful and more robust than some of the asymptotic method available in literature. 展开更多
关键词 Value at Risk VOLATILITY empirical likelihood specification test non-nested test 62G10 62P20 91B30
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Asymtotics of Dantzig Selector for a General Single-Index Model
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作者 FAN Yan GAI Yujie zhu lixing 《Journal of Systems Science & Complexity》 SCIE EI CSCD 2016年第4期1123-1144,共22页
As two popularly used variable selection methods, the Dantzig selector and the LASSO have been proved asymptotically equivalent in some scenarios. However, it is not the case in general for linear models, as disclosed... As two popularly used variable selection methods, the Dantzig selector and the LASSO have been proved asymptotically equivalent in some scenarios. However, it is not the case in general for linear models, as disclosed in Gai, Zhu and Lin's paper in 2013. In this paper, it is further shown that generally the asymptotic equivalence is not true either for a general single-index model with random design of predictors. To achieve this goal, the authors systematically investigate necessary and sufficient conditions for the consistent model selection of the Dantzig selector. An adaptive Dantzig selector is also recommended for the cases where those conditions are not satisfied. Also, different from existing methods for linear models, no distributional assumption on error term is needed with a trade-off that more stringent condition on the predictor vector is assumed. A small scale simulation is conducted to examine the performances of the Dantzig selector and the adaptive Dantzig selector. 展开更多
关键词 Adaptive Dantzig Selector Dantzig selector general single-index model model selection consistency.
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An Answer to Li's Problem
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作者 zhu lixing Cheng Ping 《Acta Mathematica Sinica,English Series》 SCIE CSCD 1995年第1期81-87,共7页
In this paper,an answer is given to a problem proposed by K.C.Li.This problem comes from the variable transformation for fitting a regression model.
关键词 net LI An Answer to Li’s Problem REAL
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Overlapped groupwise dimension reduction
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作者 ZHOU JingKe WU JianRong zhu lixing 《Science China Mathematics》 SCIE CSCD 2016年第12期2543-2560,共18页
Existing groupwise dimension reduction requires given group structure to be non-overlapped. This confines its application scope. We aim at groupwise dimension reduction with overlapped group structure or even unknown ... Existing groupwise dimension reduction requires given group structure to be non-overlapped. This confines its application scope. We aim at groupwise dimension reduction with overlapped group structure or even unknown group structure. To this end, existing groupwise dimension reduction concept is extended to be compatible with overlapped group structure. Then, the envelope method is ameliorated to deal with overlapped groupwise dimension reduction. As an application, Gaussian graphic model is employed to estimate the structure between predictors when the group structure is not given, and the amended envelope method is used for groupwise dimension reduction with graphic structure. Furthermore, the rationale of the proposed estimation procedure is explained at the population level and the estimation consistency is proved at the sample level. Finally, the finite sample performance of the proposed methods is examined via numerical simulations and a body fat data analysis. 展开更多
关键词 sufficient dimension reduction groupwise dimension reduction overlapped group structure envelope method Gaussian graphic model
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