目的:研究血清中钙、镁与妊娠高血压疾病(hypertensive disorders of pregnancy,HDP)发病的相关性。方法:选择160例孕妇为研究对象,其中确诊为HDP的80例为实验组,非HDP的80例为对照组。所有孕妇均接受钙、镁离子检测,并分析血清中钙、...目的:研究血清中钙、镁与妊娠高血压疾病(hypertensive disorders of pregnancy,HDP)发病的相关性。方法:选择160例孕妇为研究对象,其中确诊为HDP的80例为实验组,非HDP的80例为对照组。所有孕妇均接受钙、镁离子检测,并分析血清中钙、镁离子水平与HDP发病的相关性。结果:实验组血清钙、镁离子水平均低于对照组,差异有统计学意义(P<0.05);重度HDP孕妇中血清钙、镁离子水平明显低于轻度HDP孕妇,差异有统计学意义(P<0.05)。在P<0.05水平,血清钙、镁离子水平与HDP发生呈明显负相关。结论:血清中钙、镁离子指标水平与HDP发病具有明显相关性,且随着发病程度的升高而降低,可用于HDP的辅助诊断、病情评估及预后。展开更多
Novel series of limonin derivatives （V-A-I-V-A-8, V-B-I-V-B-8） were synthesized by adding various tertiary amines onto the C （7）-position of limonin. The synthesized compounds possessed favorable physicochemical p...Novel series of limonin derivatives （V-A-I-V-A-8, V-B-I-V-B-8） were synthesized by adding various tertiary amines onto the C （7）-position of limonin. The synthesized compounds possessed favorable physicochemical property, and the intrinsic solubility of the novel compounds were significantly improved, compared with limonin. Different pharmacological models were used to evaluate the analgesic and anti-inflammatory activities of the target compounds. Compound V-A-8 exhibited the strongest in vivo activity among the novel limonin analogs; its analgesic activity was more potent than aspirin and its anti-inflammatory activity was stronger than naproxen under our testing conditions.展开更多
文摘目的:研究血清中钙、镁与妊娠高血压疾病(hypertensive disorders of pregnancy,HDP)发病的相关性。方法:选择160例孕妇为研究对象,其中确诊为HDP的80例为实验组,非HDP的80例为对照组。所有孕妇均接受钙、镁离子检测,并分析血清中钙、镁离子水平与HDP发病的相关性。结果:实验组血清钙、镁离子水平均低于对照组,差异有统计学意义(P<0.05);重度HDP孕妇中血清钙、镁离子水平明显低于轻度HDP孕妇,差异有统计学意义(P<0.05)。在P<0.05水平,血清钙、镁离子水平与HDP发生呈明显负相关。结论:血清中钙、镁离子指标水平与HDP发病具有明显相关性,且随着发病程度的升高而降低,可用于HDP的辅助诊断、病情评估及预后。
基金supported by the National Natural Science Foundation of China(Grant No.21472242)the National Science and Technology Major Project for "Significant New Drugs Creation" of China(Grant No.2015ZX09102001)State Key Laboratory of Natural Medicines,China Pharmaceutical University(No.SKLNMZZCX201406)
文摘Novel series of limonin derivatives （V-A-I-V-A-8, V-B-I-V-B-8） were synthesized by adding various tertiary amines onto the C （7）-position of limonin. The synthesized compounds possessed favorable physicochemical property, and the intrinsic solubility of the novel compounds were significantly improved, compared with limonin. Different pharmacological models were used to evaluate the analgesic and anti-inflammatory activities of the target compounds. Compound V-A-8 exhibited the strongest in vivo activity among the novel limonin analogs; its analgesic activity was more potent than aspirin and its anti-inflammatory activity was stronger than naproxen under our testing conditions.
