Since the 1980s,as tourism products have developed in depth,As a new type of product,ancient town tourism has gradually been favored by tourists,thus forming a boom in the development of ancient town tourism.However,i...Since the 1980s,as tourism products have developed in depth,As a new type of product,ancient town tourism has gradually been favored by tourists,thus forming a boom in the development of ancient town tourism.However,it is worrying that the“hollowing”of culture exposed in the development process has begun to hinder the sustainable development of tourism in ancient towns.Based on this,this paper expounds the ancient town culture,reveals the performance of the“hollowization”of ancient town culture,and puts forward the idea of ancient town cultural protection and development.展开更多
Chromenones have attracted much attention since they are excellent acetylcholinesterase inhibitor(AChEi).The 1,2,3-triazoles are multifunctional anti-acetylcholinesterase(AChE)agents.In this paper,we report the three-...Chromenones have attracted much attention since they are excellent acetylcholinesterase inhibitor(AChEi).The 1,2,3-triazoles are multifunctional anti-acetylcholinesterase(AChE)agents.In this paper,we report the three-dimensional quantitative structure-activity relationship(3D-QSAR)study of 251,2,3-triazolechromenone derivatives based comparative molecular field analysis(CoMFA)and comparative molecular similarity indices analysis(CoMSIA).To construct CoMFA and CoMSIA models,the 25 active molecules were randomly divided into the training and test sets.The obtained cross-validation Q2 of the CoMFA model,the coefficient of non-cross-validation R2,and the test value F are 0.597,0.994,and 396.726,respectively.The cross-validation Q2 of the CoMSIA model,the coefficient of the non-cross-validation R2,and the test value F are 0.721,0.979,and 131.107,respectively.The predictive correlation coefficient(rpred2)is 0.728 for CoMFA and 0.805 for CoMSIA,which verifies that the model is predictable.Based on the potential maps of CoMFA and CoMSIA,a library containing a set of potent AChEi was designed.The inhibitory potential of the compounds in this library was found to be greater than the inhibitory potential of the most active compounds in the data set.The results obtained from this study laid the foundation for the development of effective drugs for AChEi.展开更多
文摘Since the 1980s,as tourism products have developed in depth,As a new type of product,ancient town tourism has gradually been favored by tourists,thus forming a boom in the development of ancient town tourism.However,it is worrying that the“hollowing”of culture exposed in the development process has begun to hinder the sustainable development of tourism in ancient towns.Based on this,this paper expounds the ancient town culture,reveals the performance of the“hollowization”of ancient town culture,and puts forward the idea of ancient town cultural protection and development.
文摘Chromenones have attracted much attention since they are excellent acetylcholinesterase inhibitor(AChEi).The 1,2,3-triazoles are multifunctional anti-acetylcholinesterase(AChE)agents.In this paper,we report the three-dimensional quantitative structure-activity relationship(3D-QSAR)study of 251,2,3-triazolechromenone derivatives based comparative molecular field analysis(CoMFA)and comparative molecular similarity indices analysis(CoMSIA).To construct CoMFA and CoMSIA models,the 25 active molecules were randomly divided into the training and test sets.The obtained cross-validation Q2 of the CoMFA model,the coefficient of non-cross-validation R2,and the test value F are 0.597,0.994,and 396.726,respectively.The cross-validation Q2 of the CoMSIA model,the coefficient of the non-cross-validation R2,and the test value F are 0.721,0.979,and 131.107,respectively.The predictive correlation coefficient(rpred2)is 0.728 for CoMFA and 0.805 for CoMSIA,which verifies that the model is predictable.Based on the potential maps of CoMFA and CoMSIA,a library containing a set of potent AChEi was designed.The inhibitory potential of the compounds in this library was found to be greater than the inhibitory potential of the most active compounds in the data set.The results obtained from this study laid the foundation for the development of effective drugs for AChEi.
