Some basic experiments in vivo have confirmed that propofol is capable of providing neuroprotection.^(1,2) Using cultured neurons, interference produced by multiple factors under in vivo situations could be eliminated...Some basic experiments in vivo have confirmed that propofol is capable of providing neuroprotection.^(1,2) Using cultured neurons, interference produced by multiple factors under in vivo situations could be eliminated, and the direct effects of propofol on neurons under anoxia/reoxygenation conditions could be observed. Evenso, there are not many in vitro experiments about propofol’s neuroprotection and only two are about anoxia of hippocampal slices and cultured hippocampal neurons.^(3,4) However, the concentrations of propofol used in those studies (20 μg/ml, 50 μmol/L and 500 μmol/L) significantly exceeded the concentrations in cerebrospinal fluid under the clinically relevant concentrations in blood.展开更多
文摘Some basic experiments in vivo have confirmed that propofol is capable of providing neuroprotection.^(1,2) Using cultured neurons, interference produced by multiple factors under in vivo situations could be eliminated, and the direct effects of propofol on neurons under anoxia/reoxygenation conditions could be observed. Evenso, there are not many in vitro experiments about propofol’s neuroprotection and only two are about anoxia of hippocampal slices and cultured hippocampal neurons.^(3,4) However, the concentrations of propofol used in those studies (20 μg/ml, 50 μmol/L and 500 μmol/L) significantly exceeded the concentrations in cerebrospinal fluid under the clinically relevant concentrations in blood.
