目的探讨阿帕替尼维持治疗一线化疗后晚期肺鳞癌的疗效及安全性。方法收集40例晚期非小细胞肺癌患者,一线治疗为4~6个周期的GP方案化疗,将疗效达稳定或缓解的患者随机分两组,一组给予最佳支持治疗(对照组),一组给予阿帕替尼治疗(观察组)...目的探讨阿帕替尼维持治疗一线化疗后晚期肺鳞癌的疗效及安全性。方法收集40例晚期非小细胞肺癌患者,一线治疗为4~6个周期的GP方案化疗,将疗效达稳定或缓解的患者随机分两组,一组给予最佳支持治疗(对照组),一组给予阿帕替尼治疗(观察组);比较两组PFS、血清VEGFR水平、KPS评分及评估安全性。结果观察组和对照组的中位PFS分别为7.6个月(95%CI:6.6~8.9)和4.3个月(95%CI:3.5~5.8)(P<0.05)。维持治疗开始前观察组和对照组患者血清中血管内皮生长因子(VEGF)和CYFRA21-1(细胞角质蛋白19片段)水平差异均无统计学意义(P>0.05),治疗后观察组患者血清中VEGF水平明显低于对照组(265.13±18.26 vs 326.35±19.38)pg/ml,(P<0.05),角质蛋白值变化不明显。阿帕替尼治疗后患者KPS评分仍基本维持在1分。患者不良反应较轻,主要为高血压、手足综合症及乏力(发生率为25%、25%及10%),经治疗后可缓解。结论阿帕替尼维持治疗一线化疗后稳定的晚期肺鳞癌患者,可提高PFS,维持较好的KPS评分,改善生活质量,安全性好。展开更多
The Cu Cr/1Cr18Ni9 Ti bi-metal materials were prepared by the solid-liquid bonding method. The microstructures, mechanical properties and formation mechanism of the bonding interface were studied. The results show tha...The Cu Cr/1Cr18Ni9 Ti bi-metal materials were prepared by the solid-liquid bonding method. The microstructures, mechanical properties and formation mechanism of the bonding interface were studied. The results show that there exists a serrated transition layer with a certain width at the interface of Cu Cr/1Cr18Ni9 Ti bi-metal materials, and the transition layer consists of Fe-based and Cu-based solid solutions. The elastic modulus and hardness reach the maximum values at the interface closing to the 1Cr18Ni9 Ti zone. The bonding temperature has a significant effect on the width and morphology of the transition layer. The interfacial bonding strength is at least 30% higher than that of the Cu Cr alloy, and the tensile fracture occurs at the side of the Cu Cr alloy rather than at the bonding interface.展开更多
文摘目的探讨阿帕替尼维持治疗一线化疗后晚期肺鳞癌的疗效及安全性。方法收集40例晚期非小细胞肺癌患者,一线治疗为4~6个周期的GP方案化疗,将疗效达稳定或缓解的患者随机分两组,一组给予最佳支持治疗(对照组),一组给予阿帕替尼治疗(观察组);比较两组PFS、血清VEGFR水平、KPS评分及评估安全性。结果观察组和对照组的中位PFS分别为7.6个月(95%CI:6.6~8.9)和4.3个月(95%CI:3.5~5.8)(P<0.05)。维持治疗开始前观察组和对照组患者血清中血管内皮生长因子(VEGF)和CYFRA21-1(细胞角质蛋白19片段)水平差异均无统计学意义(P>0.05),治疗后观察组患者血清中VEGF水平明显低于对照组(265.13±18.26 vs 326.35±19.38)pg/ml,(P<0.05),角质蛋白值变化不明显。阿帕替尼治疗后患者KPS评分仍基本维持在1分。患者不良反应较轻,主要为高血压、手足综合症及乏力(发生率为25%、25%及10%),经治疗后可缓解。结论阿帕替尼维持治疗一线化疗后稳定的晚期肺鳞癌患者,可提高PFS,维持较好的KPS评分,改善生活质量,安全性好。
基金National Key R&D Program of China(2017YFE0301402)Shaanxi Provincial Project of Special Foundation of Key Disciplines(2018ZDXM-GY-136,2019JM-595,15JF025)。
基金National Natural Science Foundation of China (52071259, 51834009)National Key R&D Program of China (2017YFE0301402)+1 种基金Research Program of Science and Technology of Shaanxi Province (2020zdzx04-04-01, 2018ZDXM-GY-136, 20JY050)Sponsored by State Key Laboratory of Long-Life High Temperature Materials (DTCC28EE190226)。
基金National Natural Science Foundation of China(51371139,51174161)the Science and Technique Innovation Program of Shaanxi Province(2012KTQ01-14)the Pivot Innovation Team of Shaanxi Electric Materials and the Infiltration Technique(2012KCT-25)
基金supported by the National Natural Science Foundation of China(Grant No.51371139)Science and Technique Innovation Program of Shaanxi Province(Grant No.2012KTCQ01-14)+1 种基金Pivot Innovation Team of Shaanxi Electric Materials and the Infiltration Technique(Grant No.2012KCT-25)Shaanxi Provincial Project of Special Foundation of Key Disciplines
文摘The Cu Cr/1Cr18Ni9 Ti bi-metal materials were prepared by the solid-liquid bonding method. The microstructures, mechanical properties and formation mechanism of the bonding interface were studied. The results show that there exists a serrated transition layer with a certain width at the interface of Cu Cr/1Cr18Ni9 Ti bi-metal materials, and the transition layer consists of Fe-based and Cu-based solid solutions. The elastic modulus and hardness reach the maximum values at the interface closing to the 1Cr18Ni9 Ti zone. The bonding temperature has a significant effect on the width and morphology of the transition layer. The interfacial bonding strength is at least 30% higher than that of the Cu Cr alloy, and the tensile fracture occurs at the side of the Cu Cr alloy rather than at the bonding interface.
