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替罗非班诱导血小板减少症一例
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作者 刘博 邹阳春 +4 位作者 冯翠萍 许慧 姬小飞 李晋创 王涛 《中华老年多器官疾病杂志》 2020年第9期697-698,共2页
替罗非班是一种可逆性糖蛋白Ⅱb/Ⅲa(glycoproteinⅡb/Ⅲa,GPⅡb/Ⅲa)受体拮抗剂,具有抑制血小板聚集与抗血栓形成等作用。替罗非班半衰期短、起效快,给药5 min后血小板抑制率可达96%,且此过程可逆,停药2~4h后,血小板功能可恢复至基础值... 替罗非班是一种可逆性糖蛋白Ⅱb/Ⅲa(glycoproteinⅡb/Ⅲa,GPⅡb/Ⅲa)受体拮抗剂,具有抑制血小板聚集与抗血栓形成等作用。替罗非班半衰期短、起效快,给药5 min后血小板抑制率可达96%,且此过程可逆,停药2~4h后,血小板功能可恢复至基础值的89%,出血时间恢复正常,安全性好,但存在各种出血并发症及血小板减少症等不良反应。急性冠脉综合征(acute coronary syndrome,ACS)的标准治疗方案是应用双联抗血小板药物基础上联合抗凝药物,对于一些高危患者还需适当加用血小板GPⅡb/Ⅲa受体拮抗剂[1],但须在用药后定期随访血小板计数,确保用药安全。本文报道1例经皮冠状动脉介入(percutaneous coronary intervention,PCI)治疗后应用替罗非班所致血小板减少患者的临床资料,以提高临床医师,特别是心血管内科医师,对替罗非班致血小板减少症的认识。 展开更多
关键词 血小板减少症 替罗非班 经皮冠状动脉介入治疗
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The main etiologies for patients presented to ER with chest pain or chest pain equivalent in Beijing,China
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作者 XUE Jun WANG Chun-ling +6 位作者 SUN Yan Pi-Lin zou yang-chun WANG Ming-xiao YANG Hong-gang YU Jing-ming Hu Da-yi 《岭南心血管病杂志》 2011年第S1期151-152,共2页
Objectives To identify the mian etilogoies for patients presented to the ER with chest pain or chest pain equivalent and further analyze the common presenting symptom of coronary heart disease patients in the ER.Metho... Objectives To identify the mian etilogoies for patients presented to the ER with chest pain or chest pain equivalent and further analyze the common presenting symptom of coronary heart disease patients in the ER.Methods We conducted a prospective,cross-sectinal survey of all patinets presented to the ER with chest pain and chest pain equivalent syndrome in 17 medical centre in Beijing,China from Ju ly to August 2009.Data was collected by structured interviews and medical record reviews.The mean follow up period was 30 days.Results A total of 5666 patients entered the study [age(58.09±18.39)years,2663 males and 3303 females]. Their final diagnoses are;Chest pain(4.65%) Coronary heart disease 1506(27.4%),Acute Heart failure 149(2.6%), Pericarditis 4(0.1%),Pulmonary embolism 11(0.2%),Aortic dissection8(0.1%),Acute cerebrovascular disease 431 (7.6%),Non-cardic chest pain 2538(44.9%).We further analyzed the cornary heart disease patients.Eight-eight percent patients with cornary heart disease have symptoms at their presentation.The other 12%? patients without symptom.71% with chest prseur sensation.38.8%with shorness of breath, 23.3%with dyspnea,irritable,1.6%syncope,1.0%Loss of Consciousness 33.2%Palpitation,22.0%dizziness,14.7% nausea and vomiting,19.1%sluggish.Conclusions A quarter of patients(27.4%) presented to the ER with chest pain or chest pain equivalent have defined etiology of coronary heart deisease.Howerer,nearly half(48.8%) of the coronary heart disease patients present with no chest pain and 18.7% CHD patients presents with chest pain equivalent syndrome. This study suggest chest pain is not a prerequisite for the diagnosis of CHD.Therefore,special vigilance and thorough coronary artery evaluation is needed for all patients with chest discomfort or respiratory distress in the ER,even for patients without chest pain complaints. 展开更多
关键词 ER ETIOLOGIES chest pain
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