Two new saponins named davuricoside H and davuricoside K were isolated from the whole plant of Lysimachia davurica. The structures of davuricoside H and davuricoside K were determined by 1-D and 2-D NMR, MS techniques...Two new saponins named davuricoside H and davuricoside K were isolated from the whole plant of Lysimachia davurica. The structures of davuricoside H and davuricoside K were determined by 1-D and 2-D NMR, MS techniques, and chemical methods to be 3β,16α ,28-trihydroxy-olean-12-en-30-oic acid-3-O-β-D-glucopyranosyl-（ 1→2 ）- [β-D-glucopyranosyl-（ 1 → 4 ） ] -α-L-arabinopyranoside and 3β,16or ,28-trihydroxy-olean-12-en-30-oic acid-3-O-{β-D- glucopyranosyl- （ 1 →2 ） - [β-D-glucopyranosyl- （ 1 →4 ） ] -α-L-arabinopyranosyl } -30-O-β-D-glucopyranosyl-ester.展开更多
The present study was designed to investigate the chemical constituents of the whole herb of Dichrocephala benthamii. A new megastigmane glucoside(compound 1), together with its four known analogues(compounds 2-5), wa...The present study was designed to investigate the chemical constituents of the whole herb of Dichrocephala benthamii. A new megastigmane glucoside(compound 1), together with its four known analogues(compounds 2-5), was obtained. Their structures were elucidated on the basis of spectroscopic analyses(UV, IR, MS, and 1D and 2D NMR). The absolute configuration of compound 1was assigned on the basis of CD method and chemical evidence. In addition, their cytotoxicity against human hepatoma cells(Hep G-2) was evaluated by the MTT method. Compound 5 showed weak activity against Hep G-2, while the other compounds did not show remarkable inhibitory effects.展开更多
基金Supported by the National Natural Science Foundation of China(No. 39870085).
文摘Two new saponins named davuricoside H and davuricoside K were isolated from the whole plant of Lysimachia davurica. The structures of davuricoside H and davuricoside K were determined by 1-D and 2-D NMR, MS techniques, and chemical methods to be 3β,16α ,28-trihydroxy-olean-12-en-30-oic acid-3-O-β-D-glucopyranosyl-（ 1→2 ）- [β-D-glucopyranosyl-（ 1 → 4 ） ] -α-L-arabinopyranoside and 3β,16or ,28-trihydroxy-olean-12-en-30-oic acid-3-O-{β-D- glucopyranosyl- （ 1 →2 ） - [β-D-glucopyranosyl- （ 1 →4 ） ] -α-L-arabinopyranosyl } -30-O-β-D-glucopyranosyl-ester.
基金supported financially by the Chinese National S&T Special Project on Major New Drug Innovation(No.2013ZX09508104)Innovative Research Team in Institute of Medicinal Plant Development(IMPLD)
文摘The present study was designed to investigate the chemical constituents of the whole herb of Dichrocephala benthamii. A new megastigmane glucoside(compound 1), together with its four known analogues(compounds 2-5), was obtained. Their structures were elucidated on the basis of spectroscopic analyses(UV, IR, MS, and 1D and 2D NMR). The absolute configuration of compound 1was assigned on the basis of CD method and chemical evidence. In addition, their cytotoxicity against human hepatoma cells(Hep G-2) was evaluated by the MTT method. Compound 5 showed weak activity against Hep G-2, while the other compounds did not show remarkable inhibitory effects.
