目的探讨2型心肾综合征患者肾小球滤过率与脑钠肽与临床病情程度相关性。方法选择124例心力衰竭合并2型心肾综合征的住院患者为观察组,根据纽约心功能分级(New York Heart Function Assessment,NYHA)将入选患者分为NYHAⅡ级组、NYHAⅢ...目的探讨2型心肾综合征患者肾小球滤过率与脑钠肽与临床病情程度相关性。方法选择124例心力衰竭合并2型心肾综合征的住院患者为观察组,根据纽约心功能分级(New York Heart Function Assessment,NYHA)将入选患者分为NYHAⅡ级组、NYHAⅢ级组、NYHAⅣ级组。同期住院无心力衰竭的心血管病患者126例,为对照组。收集各项临床数据进行分析。结果NYHAⅡ级组、NYHAⅢ级组、NYHAⅣ级组与对照组比较,脑钠肽水平升高,肾小球滤过率下降,差异均有统计学意义(P<0.01)。肾小球滤过率与左室射血分数呈正相关(r=0.368,P<0.01)。结论脑钠肽水平、估算的肾小球滤过率与2型心肾综合征病情程度相关。展开更多
目的分析血吸虫病肝纤维化患者血脂代谢特点,探讨临床意义。方法2019年1月—2020年12月,以龙游县人民医院与开化县中医医院204例血吸虫病肝纤维化患者为观察组,健康体检者212例为对照组,B型超声检查肝纤维化程度,检测总胆固醇(total cho...目的分析血吸虫病肝纤维化患者血脂代谢特点,探讨临床意义。方法2019年1月—2020年12月,以龙游县人民医院与开化县中医医院204例血吸虫病肝纤维化患者为观察组,健康体检者212例为对照组,B型超声检查肝纤维化程度,检测总胆固醇(total cholesterol,TC)、三酰甘油(triglyeride,TG)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C),计算TG/HDL-C的对数转换值[log(TG/HDL-C)]为血浆致动脉硬化指数(atherogenic index of plasma,AIP)。结果观察组血清TC、TG、HDL-C、LDL-C均低于对照组(P<0.05);观察组AIP高于对照组(P<0.01)。全组AIP与TBi L、AST、APRI水平之间相关性分别为TBi L(r=0.368,P<0.01)、AST(r=0.244,P<0.01)、APRI(r=0.144,P<0.05)。结论血吸虫病肝纤维化患者血脂水平较对照组下降,HDL-C下降较为明显,AIP升高,通过血脂多项参数改变综合观察血吸虫病肝纤维化病情,对临床工作有参考价值。展开更多
Background Non-small cell lung cancer （NSCLC） is the leading cause of cancer mortality worldwide. Platelet activation may play an important role in pathologic progress in lung cancer. In this study, we aimed to clar...Background Non-small cell lung cancer （NSCLC） is the leading cause of cancer mortality worldwide. Platelet activation may play an important role in pathologic progress in lung cancer. In this study, we aimed to clarify the influence of activated platelets on lung cancer generation and growth, and the relationship among these functional and ultrastructural chanqes of platelets and the severity of pathoeenetic condition in these Datients with NSCLC.Methods One hundred and thirty-six cases of patients with pathologically confirmed NSCLC were included in this study. Fifty-four healthy people were enrolled as controls. The change of ultra microstructure and activity of blood platelets were observed under the transmission and scanning electron microscope. Simultaneous determination of plasma granule membrane protein 140 （GMP-140） was made.Results Transmission electron microscopy showed remarkable changes of ultra microstructure of platelets in patients with NSCLC, including swelling, increase of α-granules, vesicles, and glycogenosome. Scanning electron microscopy showed many more surface processes and wrinkles on platelets in patients with NSCLC. The reference plasma levels of GMP-140 of healthy controls were （18.2±2.7） μg/L. The plasma levels of GMP-140 in patients with NSCLC were （47.8±12.3） μg/L, which were much higher than those of the controls. There was a medium positive correlation between plasma levels of GMP-140 and amount of α-granules （r=0.514, P 〈0.01） and a high positive correlation between plasma levels of GMP-140 and area of platelet （r=0.84, P 〈0.01） in patients with NSCLC. The Kaplan-Meier survival curve analysis showed significant shift to the left in patients with NSCLC whose a-granules per platelet were 19 or more compared to those 18 or less （Log rank statistic, X^2= 17.38, P〈0.01）.Conclusions There are significant activated changes of ultra microstructure and increased activity of blood platelets in patients with NSCLC. These activated platelets may play an important role in the generation and growth of lung cancer. These changes can be used as a diagnostic index of severity, progression, and prognosis of NSCLC.展开更多
文摘目的探讨2型心肾综合征患者肾小球滤过率与脑钠肽与临床病情程度相关性。方法选择124例心力衰竭合并2型心肾综合征的住院患者为观察组,根据纽约心功能分级(New York Heart Function Assessment,NYHA)将入选患者分为NYHAⅡ级组、NYHAⅢ级组、NYHAⅣ级组。同期住院无心力衰竭的心血管病患者126例,为对照组。收集各项临床数据进行分析。结果NYHAⅡ级组、NYHAⅢ级组、NYHAⅣ级组与对照组比较,脑钠肽水平升高,肾小球滤过率下降,差异均有统计学意义(P<0.01)。肾小球滤过率与左室射血分数呈正相关(r=0.368,P<0.01)。结论脑钠肽水平、估算的肾小球滤过率与2型心肾综合征病情程度相关。
文摘目的分析血吸虫病肝纤维化患者血脂代谢特点,探讨临床意义。方法2019年1月—2020年12月,以龙游县人民医院与开化县中医医院204例血吸虫病肝纤维化患者为观察组,健康体检者212例为对照组,B型超声检查肝纤维化程度,检测总胆固醇(total cholesterol,TC)、三酰甘油(triglyeride,TG)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C),计算TG/HDL-C的对数转换值[log(TG/HDL-C)]为血浆致动脉硬化指数(atherogenic index of plasma,AIP)。结果观察组血清TC、TG、HDL-C、LDL-C均低于对照组(P<0.05);观察组AIP高于对照组(P<0.01)。全组AIP与TBi L、AST、APRI水平之间相关性分别为TBi L(r=0.368,P<0.01)、AST(r=0.244,P<0.01)、APRI(r=0.144,P<0.05)。结论血吸虫病肝纤维化患者血脂水平较对照组下降,HDL-C下降较为明显,AIP升高,通过血脂多项参数改变综合观察血吸虫病肝纤维化病情,对临床工作有参考价值。
文摘Background Non-small cell lung cancer （NSCLC） is the leading cause of cancer mortality worldwide. Platelet activation may play an important role in pathologic progress in lung cancer. In this study, we aimed to clarify the influence of activated platelets on lung cancer generation and growth, and the relationship among these functional and ultrastructural chanqes of platelets and the severity of pathoeenetic condition in these Datients with NSCLC.Methods One hundred and thirty-six cases of patients with pathologically confirmed NSCLC were included in this study. Fifty-four healthy people were enrolled as controls. The change of ultra microstructure and activity of blood platelets were observed under the transmission and scanning electron microscope. Simultaneous determination of plasma granule membrane protein 140 （GMP-140） was made.Results Transmission electron microscopy showed remarkable changes of ultra microstructure of platelets in patients with NSCLC, including swelling, increase of α-granules, vesicles, and glycogenosome. Scanning electron microscopy showed many more surface processes and wrinkles on platelets in patients with NSCLC. The reference plasma levels of GMP-140 of healthy controls were （18.2±2.7） μg/L. The plasma levels of GMP-140 in patients with NSCLC were （47.8±12.3） μg/L, which were much higher than those of the controls. There was a medium positive correlation between plasma levels of GMP-140 and amount of α-granules （r=0.514, P 〈0.01） and a high positive correlation between plasma levels of GMP-140 and area of platelet （r=0.84, P 〈0.01） in patients with NSCLC. The Kaplan-Meier survival curve analysis showed significant shift to the left in patients with NSCLC whose a-granules per platelet were 19 or more compared to those 18 or less （Log rank statistic, X^2= 17.38, P〈0.01）.Conclusions There are significant activated changes of ultra microstructure and increased activity of blood platelets in patients with NSCLC. These activated platelets may play an important role in the generation and growth of lung cancer. These changes can be used as a diagnostic index of severity, progression, and prognosis of NSCLC.
