Massive pro-inflammatory cytokines production has been correlated with the pathogenesis of severe dengue disease.The active compound of mangosteen fruit pericarps,α-mangostin,has been commonly used as traditional med...Massive pro-inflammatory cytokines production has been correlated with the pathogenesis of severe dengue disease.The active compound of mangosteen fruit pericarps,α-mangostin,has been commonly used as traditional medicine and dietary supplement.We examined the effect ofα-mangostin against dengue virus(DENV)infection in human peripheral blood mononuclear cells(PBMC)by the measurement of virus titer and TNF-αand IFN-γcytokines concentration post infection.Increasing concentration ofα-mangostin inhibited virus replication and reduced inflammatory cytokines expression at 24-and 48-h post infection.Our results support the potential use ofα-mangostin as anti-antiviral and anti-inflammatory therapies in the treatment of dengue.展开更多
文摘Massive pro-inflammatory cytokines production has been correlated with the pathogenesis of severe dengue disease.The active compound of mangosteen fruit pericarps,α-mangostin,has been commonly used as traditional medicine and dietary supplement.We examined the effect ofα-mangostin against dengue virus(DENV)infection in human peripheral blood mononuclear cells(PBMC)by the measurement of virus titer and TNF-αand IFN-γcytokines concentration post infection.Increasing concentration ofα-mangostin inhibited virus replication and reduced inflammatory cytokines expression at 24-and 48-h post infection.Our results support the potential use ofα-mangostin as anti-antiviral and anti-inflammatory therapies in the treatment of dengue.
