Refiector Deformation Measurement and Correction Methodology of Large Antenna Based on Phased Array Feed

To solve the problem of time-consuming measurement and correction of large antennas’reflector deformation,a new microwave holography methodology based on a Phased Array Feed(PAF)is proposed.Starting from the known expression of receiving signals in microwave holography,the theory of PAF holography is derived through Geometrical Optics.Reflector deformation,as well as pointing deviation and subreflector offset,can be calculated out by applying the derived equations.A measurement and correction system based on PAF holography is depicted,and two kinds of measurement methods are illustrated.The proposed measurement methodology is verified by numerical simulation,and its measurement error is analyzed.The results indicate that our proposed methodology is feasible,especially for Cassegrain antennas.

老年患者肝切除术后谵妄的危险因素分析

目的探讨老年患者肝切除术后谵妄(POD)的危险因素及对预后的影响。方法回顾性分析2018年1月至2022年1月于徐州市中心医院全身麻醉下行肝切除术的314例老年患者的临床资料,根据是否发生POD将患者分为POD组(66例)和非POD组(248例)。采用SPSS软件(美国Version 26)与R软件(美国Version 4.1.2)进行数据分析及绘图。根据数据类型,分别采用t检验、秩和检验、χ^(2)检验、Fisher确切概率法或Wilcoxon秩和检验进行组间比较。采用单因素分析方法和多因素logistic回归方法分析老年患者肝切除术后POD发生的独立危险因素。结果314例老年肝切除患者中,21.0%(66/314)发生POD。高龄(OR=1.167,95%CI 1.058~1.287;P<0.001)、体质量指数<18.5 kg/m^(2)(OR=2.115,95%CI 1.124~3.980;P=0.018)、术前低简易智力状态检查量表评分(OR=1.096,95%CI 1.047~1.148;P=0.021)、术前高查尔森合并症指数得分(OR=1.458,95%CI 1.132~1.878;P=0.007)、手术时间长(OR=1.043,95%CI 1.025~1.061;P=0.010)、术后入重症监护室(OR=2.481,95%CI 1.554~3.961;P<0.001),术后24 h视觉模拟评分高(OR=1.038,95%CI 1.017~1.059;P=0.014)是老年肝切除患者POD的独立危险因素。该多因素logistic回归模型对POD有良好的区分能力(曲线下面积=0.865,95%CI 0.795~0.936),以及较高的拟合程度(Hosmer-Lemeshow拟合优度检验,χ^(2)=5.199,P=0.804)。结论外科医师与麻醉医师可通过术前评估及早识别存在POD风险的老年患者,改善术前状态,优化围术期管理,从而降低老年肝切除患者POD的发生率。

A New Method of Frequency Fluctuation Estimation and IPS Processing Results Based on the Downlink Signal of Tianwen-1

The radio-occultation observations taken by Tianwen-1 are aiming to study the properties of solar wind.A new method of frequency fluctuation(FF)estimation is presented for processing the down-link signals of Tianwen-1 during the occultation period to study the properties of the coronal plasma at the heliocentric distances of 4.48–19 R_(⊙).Because of low S/N as well as the phase fluctuation phenomena caused by solar activity,a Kalman based on polynomial prediction methods is proposed to avoid the phase locked loop loss lock.A new detrend method based on multi-level iteration correction is proposed to estimate Doppler shift to get more accurate power density spectra of FF in the low frequency region.The data analyze procedure is used to get the properties of the solar corona during the occultation.The method was finally verified at the point when the solar offset is 5.7 R_(⊙),frequency tracking was successfully performed on data with a carrier-to-noise ratio of about 28 dBHz.The density spectra obtained by the improved method are basically the same when the frequency is greater than 2 mHz,the uncertainty in the result of the rms of the FF obtained by removing the trend term with different order polynomials is less than 3.3%.The data without eliminating interference show a large error for different detrending orders,which justifies the need for an improved approach.Finally,the frequency fluctuation results combined with the information on intensity fluctuation obtained by the new method are compared with the results of the integrated Space Weather Analysis system and theoretical formula,which verifies that the processing results in this paper have a certain degree of credibility.

新媒体平台对新冠肺炎舆情传播的影响研究

新媒体平台能够有效促进信息公开透明,避免谣言扩散;提升公众在信息透明社会背景下的话语权,帮助群众合理宣泄情感,有利于社会公众的心理健康。新媒体平台是传统媒体信息传播的有效补充,对突发性公共卫生事件舆情有着重要的影响,关注、分析新媒体信息,有利于公众及时准确接收舆情信息,促进政府部门把控舆情方向,加强公共决策的科学性。以新冠肺炎疫情期间的新媒体运行为研究对象,分析梳理新媒体信息内容特点、传播方式、公众在新媒体上的行为表现等,据此探讨突发性公共卫生事件期间新媒体的作用,以及新媒体信息传播的特征,提出突发性公共卫生事件期间舆情监控的建议,为合理应用新媒体平台、引导和监控舆情提供依据。

术前高度焦虑相关致痛因子的变化及其对术后疼痛的影响

目的探讨术前高度焦虑相关致痛因子的变化及其对术后疼痛的影响。方法选择择期在全麻下行腹腔镜手术患者71例,男27例,女44例,年龄18~60岁,ASAⅠ或Ⅱ级,根据术前24h内患者状态焦虑量表评分(SAI),将患者分为高度焦虑组(SA组,SAI>45,n=31)和低度焦虑组(MA组,SAI≤45,n=40),以ELISA法测定术前血浆前列腺素E_2(PGE_2)、P物质(SP)及5-羟色胺(5-HT)浓度。于术后3、6、12、24h评估患者VAS疼痛评分及24h镇痛泵按压总次数,计算致痛因子与VAS评分的相关性;术后2个月评估慢性疼痛发生情况。结果与MA组比较,SA组术后3、6、12、24h的VAS评分明显升高(P<0.05),24h镇痛泵按压次数明显增多(P<0.05),且术后2个月慢性疼痛发生率明显升高(P<0.05);SA组术前血浆PGE_2、5-HT浓度明显高于MA组(P<0.05),但SP浓度差异无统计学意义;PGE_2与术后VAS评分呈中度正相关(r_(3h)=0.54、r_(6h)=0.51、r_(12h)=0.50、r_(24h)=0.51,P<0.05),5-HT浓度与术后VAS评分呈低度正相关(r_(3h)=0.30、r_(6h)=0.37、r_(12h)=0.28、r_(24h)=0.32,P<0.05)。结论术前高度焦虑患者伴血浆PGE_2和5-HT浓度升高,且与术后疼痛程度呈一定的相关性;术前高度焦虑还可导致术后慢性痛发生率增加。

手术前中重度焦虑发生的相关危险因素

目的研究择期全身麻醉手术患者手术前中重度焦虑的发生率以及相关危险因素。方法在徐州医科大学附属医院选择择期行全身麻醉的手术患者562例,男225例,女337例,年龄18～85岁,ASAⅠ～Ⅲ级,术前1d采用状态特质焦虑量表(STAI)评估患者的术前焦虑程度,按照状态焦虑量表(SAI)评分将患者分为轻度焦虑组(SAI评分≤37分,n=294)和中重度焦虑组(SAI评分>37分,n=268)。采集与术前焦虑的发生可能相关的因素如年龄、性别、学历、婚姻状况、既往手术史、是否存在疼痛、术前是否诊断肿瘤及是否有高血压等。结果中重度术前焦虑的发生率为268例(47.7%)。多因素Logistic回归分析表明,女性(OR=1.846,95%CI 1.298～2.624)、单身(OR=2.208,95%CI 1.218～4.004)是中重度术前焦虑发生的危险因素。结论女性、单身可能是中重度术前焦虑发生的独立危险因素。

Evaluation of Need and Distribution of National Essential Medicines List in Village Clinics:A Cross-sectional Study Based on the Perspective of Village Doctors in China

This study aimed to evaluate the satisfaction of village doctors to essential medicines list (EML) and accessibility of essential medicines (EMs) distribution to improve the implementation of EML in village clinics.A total of 422 village doctors from five counties in three provinces of China were surveyed by questionnaires.Logistic regression analysis was conducted to identify the main factors associated with village doctors' evaluation of EML.The results showed that village doctors had a negative evaluation in satisfaction level of EML to village-based care and accessibility of EM distribution.The government should adjust EML regularly based on the actual health status of local villagers in China and focus on adding appropriate drugs that meet the needs of villagers with chronic disease.The local government should also attach importance to the distribution of EMs and maintain their supply in village clinics.

基于模糊层次评价法的联勤保障中心保障能力评估

联勤保障中心保障能力评估对于联勤保障中心建设发展具有重要意义。建立了一套联勤保障中心保障能力评估体系,基于层次分析法和模糊综合评价法构建了联勤保障中心保障能力评估模型,并运用该模型对某联勤保障中心保障能力进行了评估。所建立的指标体系较为科学合理,能够较为准确地评估联勤保障中心的保障能力。

联勤保障中心战时运用应把握的关键问题

为提高联勤保障中心战时运用成效、发挥联勤保障体制优势,从以"战"为本,全力聚焦保障打赢;以"联"为纲,着力理顺体制机制;以"网"为重,聚力升级联勤保障形态;以"点"为要,大力培育保障动力4个方面,对关系联勤保障中心战时运用的关键问题进行阐述。

Effects of antigliomatin from the scorpion venom of Buthus martensii Karsch on chloride channels on C6 glioma cells

Using whole-cell patch-clamp recordings, the effects of antigliomatin were observed on chloride channels on C6 glioma cells cultured in vitro. Antigliomatin was extracted from the venom of the scorpion Buthus martensii Karsch. Chloride channels are closed under normal osmotic pressure. When osmotic pressure was reduced to 120, 110 and 100 mV, the cell volume enlarged, chloride channels opened, and the chloride channel current increased. Three minutes after antigliomatin treatment, the chloride channel current decreased in a dose-dependent manner. These results show that antigliomatin extracted from the venom of the scorpion Buthus martensii Karsch diminishes chloride channel currents on C6 glioma cells.

A Wideband Microwave Holography Methodology for Reflector Surface Measurement of Large Radio Telescopes

Most reflector surface holographic measurements of a large radio telescope utilize a geostationary satellite as the signal source. The shortcoming is that those measurements could only be done at a limited elevation angle due to the satellite’s relatively stationary state. This paper proposed a new wideband microwave holographic measurement method based on radio sources to achieve full-elevation-angle measurement with small size reference antenna. In theoretical derivation, the time delay and phase change due to path length and device difference between the antenna under test and reference antenna are compensated first. Then the correct method of wideband holography effect, which is because of antenna pattern differing under different wavelengths when receiving a wideband signal, is presented. To verify the proposed methodology, a wideband microwave holographic measurement system is established, the data processing procedure is illustrated, and the reflector surface measurement experiments on a 40 m radio telescope at different elevation angles are conducted. The result shows that the primary reflector surface root-mean-square at around elevation angles of 28°, 44°, 49°, and 75° are respectively 0.213 mm, 0.170 mm, 0.188 mm, and 0.199 mm. It is basically consistent with the real data, indicating that the proposed wideband microwave holography methodology is feasible.

锌离子对聚乳酸结晶和热性能的影响

本文发现了Zn(Ⅱ)离子掺杂可以加快聚乳酸的结晶过程.测试了三种Zn(Ⅱ)盐(ZnCl2、ZnSt和ZnOAc),并与其它离子Mg(Ⅱ)和Ca(Ⅱ)进行对照.FT-IR以及变温拉曼光谱分析发现,经Zn(Ⅱ)离子掺杂后,聚乳酸的结晶度和结晶速率均增加,差示扫描量热技术以及X射线衍射分析也进一步证实.差示扫描量热技术测定PLA/ZnSt-0.4 wt%材料的结晶率达到22.46%,PLA/ZnOAc-O.4 wt%材料的结晶率达到24.83%.

基于网络DEA的后勤应急保障能力评估研究

为解决后勤应急保障能力的评估问题,通过分析后勤应急保障能力内涵特点,理解网络数据包络分析法原理,构建后勤应急保障能力指标体系,建立基于网络DEA的评估模型,经实例验证,找到影响后勤应急保障能力的关键因素,为下一步提高保障能力提供依据。

Construction of a high-density genetic linkage map and identification of flowering-related QTL in erect milkvetch(Astragalus adsurgens)

Erect milkvetch(Astragalus adsurgens)is a perennial legume forage crop with economic and ecological value in livestock grazing and soil-erosion control in arid and semiarid areas worldwide.Genomic information and molecular tools to support breeding and research in the species are limited.The objectives of this investigation were to map its genome using DNA markers and to identify quantitative trait loci(QTL)in the species.An F1 mapping population of 250 plants was developed from a cross between two parents with differing flowering-related traits.A high-density genetic linkage map containing 4821 markers on eight linkage groups(LGs)with a total genetic length of 1395 cM and a mean interval of 0.29 cM between adjacent markers was constructed with SLAF-seq technology.Comparative genomic analyses revealed the highest genome sequence similarity(8.71%)between erect milkvetch and Medicago truncatula,followed by Glycine max(7.65%),Cicer arietinum(7.53%),and Lupinus angustifolius(5.21%).A total of 64 significant QTL for flowering-related traits on six LGs were detected,accounting for 9.38 to 19.1%of the associated phenotype variation.Five and 48 key candidate genes for floret number and inflorescence length were identified based on the Glycyrrhiza uralensis genome.These candidate genes were involved in ubiquitination/degradation,pollen development,cell division,cytokinin biosynthetic process,and plant flowering.These findings shed light on the regulation of flowering traits in erect milkvetch and provide genomic resources for future molecular breeding of the crop.

An alfalfa MYB-like transcriptional factor MsMYBH positively regulates alfalfa seedling drought resistance and undergoes MsWAV3-mediated degradation

Drought is a major threat to alfalfa(Medicago sativa L.)production.The discovery of important alfalfa genes regulating drought response will facilitate breeding for drought-resistant alfalfa cultivars.Here,we report a genome-wide association study of drought resistance in alfalfa.We identified and functionally characterized an MYB-like transcription factor gene(MsMYBH),which increases the drought resistance in alfalfa.Compared with the wild-types,the biomass and forage quality were enhanced in MsMYBH overexpressed plants.Combined RNA-seq,proteomics and chromatin immunoprecipitation analysis showed that MsMYBH can directly bind to the promoters of MsMCP1,MsMCP2,MsPRX1A and MsCARCAB to improve their expression.The outcomes of such interactions include better water balance,high photosynthetic efficiency and scavenge excess H_(2)O_(2)in response to drought.Furthermore,an E3 ubiquitin ligase(MsWAV3)was found to induce MsMYBH degradation under long-term drought,via the 26S proteasome pathway.Furthermore,variable-number tandem repeats in MsMYBH promoter were characterized among a collection of germplasms,and the variation is associated with promoter activity.Collectively,our findings shed light on the functions of MsMYBH and provide a pivotal gene that could be leveraged for breeding drought-resistant alfalfa.This discovery also offers new insights into the mechanisms of drought resistance in alfalfa.

Geological evaluation for the carbon dioxide geological utilization and storage(CGUS)site:A review

Carbon dioxide(CO_(2))geological utilization and storage(CGUS)is the key link of CO_(2)capture,utilization,and storage(CCUS).The accurate characterization of the geological body structure is a vital prerequisite of CGUS.This paper gives a review of the multi-scale three-dimensional geological structure characterization and site selection of CO_(2)storage.It shows that there is a lack of systematic and high-precision methods for transparency characterization of multi-scale three-dimensional engineering geological structure and hydrogeological structure of a CO_(2)storage site.There is no clear understanding of the fracture evolution and gas-liquid migration process of multi-scale geological body structure under the disturbance of CO_(2)injection.There is a lack of sufficient quantitative methods for the dynamic evaluation of CO_(2)geological storage potential.The geological suitability evaluation method for site selection of CO_(2)storage is rough and has poor applicability,which is difficult to satisfy the urgent needs of CGUS site selection in the whole process of CO_(2)sequestration industrialization in the future.Thus,it is required to conduct studies on the transparency characterization of geological body structure and intelligent site selection for CO_(2)storage,which is of great importance for CGUS engineering practice.

临床药学领域药学专业学位硕士研究生实践能力考核指标体系的初探

目的明确临床药学领域的药学专业硕士学位研究生(专硕)在专业实践环节的质控要点,为建立专业实践能力考核指标体系提供依据。方法围绕该领域药学专硕应具备的核心能力、专业实践所应包含的内容和实践能力考核指标体系等问题,收集了来自医疗机构一线临床药师(受访者)填写的共计125份调查问卷,统计各选项选择率,排序并分析受访者意见集中程度。结果 97%的受访者认为实践大纲需制定相对具体的实践内容;矩阵量表结果显示,重要程度评分靠前的核心能力均围绕开展个体化药物治疗以及循证文献分析能力;在9项实践大纲所应包括的实践内容指标体系中,参与用药咨询及用药监护工作、参与治疗方案的制定及优化、参与个体化药物治疗监测及处方点评和协调处理不合理处方4项内容被认为是实践大纲制定中应该包括的具体内容和考核项目。结论临床药学领域的药学专硕实践环节考核指标体系应重点围绕用药咨询及监护能力以及药物治疗方案制定及优化能力展开,并兼顾处方点评、药历书写、处方审核调配等基本技能。

Fabry disease with acute cerebral infarction onset in a young patient

To the Editor:Fabry disease (FD)is a recessive X-linked hereditary disease.The onset age of the disease is in children and adolescents mostly.The average time from the onset of symptoms to the definite diagnosis needs 13.7 years in male patients and 16.3 years in female patients.FD happens rarely and it is easy to cause diagnosis and treatment delay.Here,we report a case of FD in a 27-year-old man who developed clinical symptoms with acute cerebral infarction onset to improve doctors' understanding of FD.

Impaired Parahippocampal Gyrus-Orbitofrontal Cortex Circuit Associated with Visuospatial Memory Deficit as a Potential Biomarker and Interventional Approach for Alzheimer Disease

The parahippocampal gyrus-orbitofrontal cortex(PHG-OFC)circuit in humans is homologous to the postrhinal cortex(POR)-ventral lateral orbitofrontal cortex(vlOFC)circuit in rodents.Both are associated with visuospatial malfunctions in Alzheimer’s disease(AD).However,the underlying mechanisms remain to be elucidated.In this study,we explored the relationship between an impaired POR-vlOFC circuit and visuospatial memory deficits through retrograde tracing and in vivo local field potential recordings in 5XFAD mice,and investigated alterations of the PHG-OFC circuit by multi-domain magnetic resonance imaging(MRI)in patients on the AD spectrum.We demonstrated that an impaired glutamatergic POR-vlOFC circuit resulted in deficient visuospatial memory in 5XFAD mice.Moreover,MRI measurements of the PHG-OFC circuit had an accuracy of 77.33%for the classification of amnestic mild cognitive impairment converters versus non-converters.Thus,the PHG-OFC circuit explains the neuroanatomical basis of visuospatial memory deficits in AD,thereby providing a potential predictor for AD progression and a promising interventional approach for AD.

成都市某寄宿制中学诺如病毒暴发疫情调查

目的探明诺如病毒暴发疫情的原因,为类似疫情的防控提供科学依据。方法 2019-04对成都市某中学按照病例定义开展诺如病毒暴发疫情病例搜索,用描述性流行病学和病例对照研究进行分析,采集标本使用荧光定量PCR检测诺如病毒,不同组别罹患率采用χ^2检验进行分析。结果本次疫情累计病例41例(20例疑似病例,16例临床确诊病例,5例实验室确诊病例),均为学生,罹患率1.62%(41/2 530),主要临床症状为腹泻和呕吐,疫情历时9.5 d,男性罹患率高于女性罹患率(χ^2=5.54,P<0.05),初一年级罹患率高于其他年级(χ^2=55.89,P<0.01),病例对照研究表明16日晚餐中的凉拌莴笋叶增加发病风险(OR=7.0,95%CI:1.1~58.1),该菜品由感染诺如病毒的厨师制作。可疑暴露餐次前有5名学生发病,其中1例为确诊病例。实验室检测结果显示6份病例肛拭子中检出诺如病毒GⅡ核酸阳性4份,15份厨师肛拭子中检出诺如病毒GⅡ核酸阳性1份。结论这起诺如病毒GⅡ型暴发疫情是2起不同传播方式的疫情同时段发生形成的,传播方式分别是人传人传播方式和经食物传播方式。