Anew kind of coenzyme B12 analogue 2',3' ,5' -trideoxyuridinyl-cobalamin(ddUCbl) wasfirst synthesized by an improved method in which 5'-O-toluenesulfonyl-2',3'-dideoxyuridilne wasfirst transorm...Anew kind of coenzyme B12 analogue 2',3' ,5' -trideoxyuridinyl-cobalamin(ddUCbl) wasfirst synthesized by an improved method in which 5'-O-toluenesulfonyl-2',3'-dideoxyuridilne wasfirst transormed into 5'-iodo-2',3'-dideoxyuridine and then reacted with reducdhydroxocobalamin. The new analogue was characterized by UV-yis and1 HNMR spectroscopy展开更多
文摘Anew kind of coenzyme B12 analogue 2',3' ,5' -trideoxyuridinyl-cobalamin(ddUCbl) wasfirst synthesized by an improved method in which 5'-O-toluenesulfonyl-2',3'-dideoxyuridilne wasfirst transormed into 5'-iodo-2',3'-dideoxyuridine and then reacted with reducdhydroxocobalamin. The new analogue was characterized by UV-yis and1 HNMR spectroscopy
