Characterization of coronary atherosclerotic plaques in a homozygous familial hypercholesterolemia visualized by optical coherence tomography

Familial hypercholesterolemia(FH)is an autosomal dominant genetic disorder,which resulted in severe elevations in low-density lipoprotein cholesterol(LDL-C)and a markedly increased risk of early-onset coronary disease.[1]t is most frequently caused by loss-of-function mutations in genes affecting the LDL receptor,which clears LDL particles from plasma.

Impact of prior cerebrovascular events on patients with unprotected left main coronary artery disease treated with coronary artery bypass grafting or percutaneous coronary intervention

Treatment of unprotected left main coronary artery(ULMCA)disease with coronary artery bypass grafting(CABG)or percutaneous coronary intervention(PCI)has developed rapidly during the past decades.The optimal revascularization strategy has been a subject of debate,with several randomized controlled trials and metaanalyses comparing outcomes of CABG and PCI.