Gliomas are progressive and infiltrating primary brain tumors.National Comprehensive Cancer Network points out that for low-grade gliomas(LGGs)patients in a highrisk group(<40 years old and subtotal resection),stan...Gliomas are progressive and infiltrating primary brain tumors.National Comprehensive Cancer Network points out that for low-grade gliomas(LGGs)patients in a highrisk group(<40 years old and subtotal resection),standard strategies are maximum safe resection with radiotherapy and adjuvant chemotherapy;however,the guidelines do not address the question whether patients need adjuvant therapy immediately after diagnosis because of RTOG 9802.[1]Temozolomide(TMZ)is one of the first-line regimens used in LGGs chemotherapy,and results of EORTC 22033-26033 have shown that compared to TMZ chemotherapy,radiotherapy did not prolong progression-free survival(PFS)in LGGs patients significantly,and overall survival(OS)outcomes remain unknown.[2]A 12-year follow-up for patients<40 years showed that radiotherapy could cause significant treatment-related side effects such as cognitive dysfunction.展开更多
基金by the Chinese Society of Clinical Oncology(No.CSNO-2015-MSD06)Shi-Wen Yuan’s effort was supported by the National Institute of Mental Health(No.R25MH101076).
文摘Gliomas are progressive and infiltrating primary brain tumors.National Comprehensive Cancer Network points out that for low-grade gliomas(LGGs)patients in a highrisk group(<40 years old and subtotal resection),standard strategies are maximum safe resection with radiotherapy and adjuvant chemotherapy;however,the guidelines do not address the question whether patients need adjuvant therapy immediately after diagnosis because of RTOG 9802.[1]Temozolomide(TMZ)is one of the first-line regimens used in LGGs chemotherapy,and results of EORTC 22033-26033 have shown that compared to TMZ chemotherapy,radiotherapy did not prolong progression-free survival(PFS)in LGGs patients significantly,and overall survival(OS)outcomes remain unknown.[2]A 12-year follow-up for patients<40 years showed that radiotherapy could cause significant treatment-related side effects such as cognitive dysfunction.
