Impact of Different Contour Hedgerows on Runoff,Nutrient and Soil on Sloping Farmland in Danjiangkou Reservoir Region of China

Soil and water loss has been a major environmental problem in the Danjiangkou Reservoir Region.A study of 14°sloping farmland was performed on impact of different contour hedgerows on runoff,losses of soil and nutrients during 2008 and 2011,with five treatments and three replications.The winter wheat and summer maize were used as the test crops.Treatments consisted of four hedgerows:Amorpha(Amorpha fruticosa L.),Honeysuckle(Lonicera japonica Thunb.),Day-lily flower(Hemerocallis citrina Baroni.),and Sabaigrass(Eulaliopsis binata),and a control without hedgerow.Result showed that the runoff under the control treatment was much higher than that of hedgerows.Amorpha could reduce the runoff by 35.2%compared with the control.Soil losses in four hedgerows showed significant reduction in four years(e.g.,Amorpha:78.3%;Honeysuckle:77.1%).Nutrient losses in winter were much higher than that in summer,especially total nitrogen,total phosphorus and total potassium,even though there was an abundant precipitation in summer.Hedgerows greatly affected the soil and nutrient losses on slopping farmland compared with the control treatment,especially Amorpha treatment.The present study found that the Amorpha could be used as the hedgerow species for reducing soil and water loss in the Danjiangkou Reservoir Region.

Molecularly engineered truncated tissue factor with therapeutic aptamers for tumor-targeted delivery and vascular infarction

Selective occlusion of tumor vasculature has proven to be an effective strategy for cancer therapy.Among vascular coagulation agents,the extracellular domain of coagulation-inducing protein tissue factor,truncated tissue factor(tTF),is the most widely used.Since the truncated protein exhibits no coagulation activity and is rapidly cleared in the circulation,free tTF cannot be used for cancer treatment on its own but must be combined with other moieties.We here developed a novel,tumor-specific tTF delivery system through coupling tTF with the DNA aptamer,AS1411,which selectively binds to nucleolin receptors overexpressing on the surface of tumor vascular endothelial cells and is specifically cytotoxic to target cells.Systemic administration of the tTF-AS1411 conjugates into tumor-bearing animals induced intravascular thrombosis solely in tumors,thus reducing tumor blood supply and inducing tumor necrosis without apparent side effects.This conjugate represents a uniquely attractive candidate for the clinical translation of vessel occlusion agent for cancer therapy.