The aggregation of inorganic particles with high mass ratio will form a heterogeneous electric field in the solid polymer electrolytes(SPEs),which is difficult to be compatible with lithium anode,leading to inadequate...The aggregation of inorganic particles with high mass ratio will form a heterogeneous electric field in the solid polymer electrolytes(SPEs),which is difficult to be compatible with lithium anode,leading to inadequate ionic conductivity.Herein,a facile spray drying method is adopted to increase the mass ratio of inorganic particles and solve the aggregation problems of fillers simultaneously.The polyvinylidene fluoride(PVDF)with lithium bis(trifluoromethanesulfonyl)imide(LiTFSI)covers the surface of each Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12)(LLZTO)granules during the nebulization process,then forming flat solid electrolytes via layer-by-layer deposition.Characterized by the atomic force microscope,the obtained solid electrolytes achieve a homogenous dispersion of Young’s modulus and surface electric field.As a result,the as-prepared SPEs present high tensile strength of 7.1 MPa,high ionic conductivity of 1.86×10^(−4)S·cm^(−1)at room temperature,and wide electrochemical window up to 5.0 V,demonstrating increased mechanical strength and uniform lithium-ion migration channels for SPEs.Thanks to the as-prepared SPEs,the lithiumsymmetrical cells show a highly stable Li plating/stripping cycling for over 1,000 h at 0.1 mA·cm^(−2).The corresponding Li/LCoO_(2)batteries also present good rate capability and excellent cyclic performance with capacity retention of 80%after 100 cycles at room temperature.展开更多
Development of simple methods for controlled integration of DNA molecules with metal-organic frameworks(MOFs)is important for various biomedical applications,yet remains a challenge.Herein,a simple and general approac...Development of simple methods for controlled integration of DNA molecules with metal-organic frameworks(MOFs)is important for various biomedical applications,yet remains a challenge.Herein,a simple and general approach to load DNA on the surface of MOFs is developed via one-pot self-assembly of DNA and FeII ions on nanoscale MOFs,resulting in hierarchical core-shell nanostructures of metal-organic@metal-DNA coordination polymers.The strategy enables assembly of DNA molecules on MOFs with ultra-high contents and precise controllability.By incorporation of a chemotherapeutic drug into the Fe-DNA shell,the systems allow to integrate chemotherapy and gene therapy with photodynamic therapy for combinational tumor treatment.Moreover,the hybrid nanostructures enable light-triggered production of cytotoxic singlet oxygen,which further boosts the endosomal escape of the system for an enhanced gene silencing efficacy and thus improved therapeutic outcome.This work highlights a robust approach for the construction of coordination-based drug delivery systems to combat tumor.展开更多
基金the financial support from the National Natural Science Foundation of China(No.21805147).
文摘The aggregation of inorganic particles with high mass ratio will form a heterogeneous electric field in the solid polymer electrolytes(SPEs),which is difficult to be compatible with lithium anode,leading to inadequate ionic conductivity.Herein,a facile spray drying method is adopted to increase the mass ratio of inorganic particles and solve the aggregation problems of fillers simultaneously.The polyvinylidene fluoride(PVDF)with lithium bis(trifluoromethanesulfonyl)imide(LiTFSI)covers the surface of each Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12)(LLZTO)granules during the nebulization process,then forming flat solid electrolytes via layer-by-layer deposition.Characterized by the atomic force microscope,the obtained solid electrolytes achieve a homogenous dispersion of Young’s modulus and surface electric field.As a result,the as-prepared SPEs present high tensile strength of 7.1 MPa,high ionic conductivity of 1.86×10^(−4)S·cm^(−1)at room temperature,and wide electrochemical window up to 5.0 V,demonstrating increased mechanical strength and uniform lithium-ion migration channels for SPEs.Thanks to the as-prepared SPEs,the lithiumsymmetrical cells show a highly stable Li plating/stripping cycling for over 1,000 h at 0.1 mA·cm^(−2).The corresponding Li/LCoO_(2)batteries also present good rate capability and excellent cyclic performance with capacity retention of 80%after 100 cycles at room temperature.
基金supported by the National Natural Science Foundation of China(No.32271462)the Young Innovation Promotion Association CAS,National Key R&D Program of China(No.2022YFA1206000)the Strategic Priority Research Program of Chinese Academy of Sciences(No.XDB36000000).
文摘Development of simple methods for controlled integration of DNA molecules with metal-organic frameworks(MOFs)is important for various biomedical applications,yet remains a challenge.Herein,a simple and general approach to load DNA on the surface of MOFs is developed via one-pot self-assembly of DNA and FeII ions on nanoscale MOFs,resulting in hierarchical core-shell nanostructures of metal-organic@metal-DNA coordination polymers.The strategy enables assembly of DNA molecules on MOFs with ultra-high contents and precise controllability.By incorporation of a chemotherapeutic drug into the Fe-DNA shell,the systems allow to integrate chemotherapy and gene therapy with photodynamic therapy for combinational tumor treatment.Moreover,the hybrid nanostructures enable light-triggered production of cytotoxic singlet oxygen,which further boosts the endosomal escape of the system for an enhanced gene silencing efficacy and thus improved therapeutic outcome.This work highlights a robust approach for the construction of coordination-based drug delivery systems to combat tumor.
