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分子骨架编辑在药物合成中的应用与展望
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作者 贺静远 王泽铠 +2 位作者 戚显玮 陈开元 卞江 《大学化学》 CAS 2023年第10期313-323,共11页
分子编辑是有机合成领域亘古不变的研究热点,其包括外围编辑与骨架编辑。在过去,分子编辑往往着重于C―H键的外围编辑,而骨架编辑则是近年来新兴起的方法学。这一类反应操作简单,专一性强,可以大幅简化合成路线,在药物合成与开发领域应... 分子编辑是有机合成领域亘古不变的研究热点,其包括外围编辑与骨架编辑。在过去,分子编辑往往着重于C―H键的外围编辑,而骨架编辑则是近年来新兴起的方法学。这一类反应操作简单,专一性强,可以大幅简化合成路线,在药物合成与开发领域应用广泛。本文基于常见的几类分子编辑反应,通过与传统方法对比的方式介绍两例分子骨架编辑在药物合成中的应用,并通过对该领域前沿发展的介绍,对该方法学的未来应用进行展望。 展开更多
关键词 分子编辑 骨架编辑 药物合成 药物开发
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Multi-Period Resilient Model for VSC-Based AC-DC HDS Considering Public-Safety Power Shutoff to Mitigate Wildfires
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作者 zekai wang Tao Ding +3 位作者 Xiaosheng Zhang Chenggang Mu Pengwei Du Fangxing Li 《CSEE Journal of Power and Energy Systems》 SCIE EI CSCD 2024年第2期821-833,共13页
This paper proposes a voltage source converter (VSC) -based AC-DC hybrid distribution system (HDS) resilient model to mitigate power outages caused by wildfires. Before a wildfire happens, the public-safety power shut... This paper proposes a voltage source converter (VSC) -based AC-DC hybrid distribution system (HDS) resilient model to mitigate power outages caused by wildfires. Before a wildfire happens, the public-safety power shutoff (PSPS) strategy is applied to actively cut some vulnerable lines which may easily cause wildfires, and reinforce some lines that are connected to critical loads. To mitigate load shedding caused by active line disconnection in the PSPS strategy, network reconfiguration is applied before the wildfire occurrence. During the restoration period, repair crews (RCs) repair faulted lines, and network reconfiguration is also taken into consideration in the recovery strategy to pick up critical loads. Since there exists possible errors in the wildfire prediction, several different scenarios of wildfire occurrence have been taken into consideration, leading to the proposition of a stochastic multi-period resilient model for the VSC-based AC-DC HDS. To accelerate the computational performance, a progressive hedging algorithm has been applied to solve the stochastic model which can be written as a mixed-integer linear program. The proposed model is verified on a 106-bus AC-DC HDS under wildfire conditions, and the result shows the proposed model not only can improve the system resilience but also accelerate computational speed. 展开更多
关键词 AC-DC hybrid distribution system restoration network reconfiguration progressive hedging public safety power shutoffs strategy resilience
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Design,fabrication,and realisation of a robotic fish actuated by dielectric elastomer with a passive fin
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作者 zekai wang Junqiang Lou +2 位作者 Xingdong Xiao Guoping Li Yimin Deng 《IET Cyber-Systems and Robotics》 EI 2023年第2期48-55,共8页
Robotic fish actuated by smart materials has attracted extensive attention and has been widely used in many applications.In this study,a robotic fish actuated by dielectric elastomer(DE)films is proposed.The tensile b... Robotic fish actuated by smart materials has attracted extensive attention and has been widely used in many applications.In this study,a robotic fish actuated by dielectric elastomer(DE)films is proposed.The tensile behaviours of DE film VHB4905 are studied,and the Ogden constitutive equation is employed to describe the stress‐strain behaviour of the DE film.The fabrication processes of the robotic fish,including prestretching treatment of the DE films,electrode coating with carbon paste,and waterproof treatment,are illustrated in detail.The dynamic response of the fabricated DE actuators under different excitation voltages is tested based on the experimental setup.Experimental results show that the first‐order natural frequencies of the obtained DE actuator in air is 4.05 Hz.Finally,the swimming performances of the proposed robotic fish at different driving levels are demonstrated,and it achieves an average swimming speed of 20.38 mm/s,with a driving voltage of 5kV at 0.8 Hz. 展开更多
关键词 dielectric elastomer FABRICATION robotic fish swimming performances
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Deep learning for non-parameterized MEMS structural design 被引量:3
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作者 Ruiqi Guo Fanping Sui +5 位作者 Wei Yue zekai wang Sedat Pala Kunying Li Renxiao Xu Liwei Lin 《Microsystems & Nanoengineering》 SCIE EI CSCD 2022年第4期251-260,共10页
The geometric designs of MEMS devices can profoundly impact their physical properties and eventual performances.However,it is challenging for researchers to rationally consider a large number of possible designs,as it... The geometric designs of MEMS devices can profoundly impact their physical properties and eventual performances.However,it is challenging for researchers to rationally consider a large number of possible designs,as it would be very time-and resource-consuming to study all these cases using numerical simulation.In this paper,we report the use of deep learning techniques to accelerate the MEMS design cycle by quickly and accurately predicting the physical properties of numerous design candidates with vastly different geometric features.Design candidates are represented in a nonparameterized,topologically unconstrained form using pixelated black-and-white images.After sufficient training,a deep neural network can quickly calculate the physical properties of interest with good accuracy without using conventional numerical tools such as finite element analysis.As an example,we apply our deep learning approach in the prediction of the modal frequency and quality factor of disk-shaped microscale resonators.With reasonable training,our deep learning neural network becomes a high-speed,high-accuracy calculator:it can identify the flexural mode frequency and the quality factor 4.6×10^(3)times and 2.6×10^(4)times faster,respectively,than conventional numerical simulation packages,with good accuracies of 98.8±1.6%and 96.8±3.1%,respectively.When simultaneously predicting the frequency and the quality factor,up to~96.0%of the total computation time can be saved during the design process.The proposed technique can rapidly screen over thousands of design candidates and promotes experience-free and data-driven MEMS structural designs. 展开更多
关键词 STRUCTURAL DEEP FASTER
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