Osteoarthritis(OA)has emerged as a significant health concern among the elderly population,with increasing attention paid to ferroptosis-induced OA in recent years.However,the prolonged use of nonsteroidal anti-inflam...Osteoarthritis(OA)has emerged as a significant health concern among the elderly population,with increasing attention paid to ferroptosis-induced OA in recent years.However,the prolonged use of nonsteroidal anti-inflammatory drugs or corticosteroids can lead to a series of side effects and limited therapeutic efficacy.This study aimed to employ the Mannich condensation reaction between epigallocatechin-3-gallate(EGCG)and selenomethionine(SeMet)to efficiently synthesize polyphenol-based nanodrugs in aqueous media for treating OA.Molecular biology experiments demonstrated that EGCG-based nanodrugs(ES NDs)could effectively reduce glutathione peroxidase 4(GPX4)inactivation,abnormal Fe2+accumulation,and lipid peroxidation induced by oxidative stress,which ameliorated the metabolic disorder of chondrocytes and other multiple pathological processes triggered by ferroptosis.Moreover,imaging and histopathological analysis of the destabilization of the medial meniscus model in mice confirmed that ES NDs exhibiting significant therapeutic effects in relieving OA.The intra-articular delivery of ES NDs represents a promising approach for treating OA and other joint inflammatory diseases.展开更多
To the Editor:The spine is a common site for tumor metastasis.Patients with spinal metastases have pain,pathological fractures and spinal deformities owing to the tumor invasion of spinal bones.At present,the mouse mo...To the Editor:The spine is a common site for tumor metastasis.Patients with spinal metastases have pain,pathological fractures and spinal deformities owing to the tumor invasion of spinal bones.At present,the mouse model is a very important tool for spinal metastases-related studies.[1]It is crucial to elucidate the pathophysiological mechanism underlying spinal metastases,improve the diagnosis and treatment guidelines,and develop new therapeutic methods.In this study,we have summarized various mouse spinal metastasis models and the applicable research contents.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.81972128 to Xuesong Zhang)National Natural Science Foundation of China(Grant No.82072478 to Yunpeng Zhao)the Application of Clinical Features of Capital City of Science and Technology Commission China BEIJING Special Subject(Z181100001718180 to Xuesong Zhang).
文摘Osteoarthritis(OA)has emerged as a significant health concern among the elderly population,with increasing attention paid to ferroptosis-induced OA in recent years.However,the prolonged use of nonsteroidal anti-inflammatory drugs or corticosteroids can lead to a series of side effects and limited therapeutic efficacy.This study aimed to employ the Mannich condensation reaction between epigallocatechin-3-gallate(EGCG)and selenomethionine(SeMet)to efficiently synthesize polyphenol-based nanodrugs in aqueous media for treating OA.Molecular biology experiments demonstrated that EGCG-based nanodrugs(ES NDs)could effectively reduce glutathione peroxidase 4(GPX4)inactivation,abnormal Fe2+accumulation,and lipid peroxidation induced by oxidative stress,which ameliorated the metabolic disorder of chondrocytes and other multiple pathological processes triggered by ferroptosis.Moreover,imaging and histopathological analysis of the destabilization of the medial meniscus model in mice confirmed that ES NDs exhibiting significant therapeutic effects in relieving OA.The intra-articular delivery of ES NDs represents a promising approach for treating OA and other joint inflammatory diseases.
基金supported by a grant from the Natural Science Foundation of Shanxi Province(No.202204041101023)
文摘To the Editor:The spine is a common site for tumor metastasis.Patients with spinal metastases have pain,pathological fractures and spinal deformities owing to the tumor invasion of spinal bones.At present,the mouse model is a very important tool for spinal metastases-related studies.[1]It is crucial to elucidate the pathophysiological mechanism underlying spinal metastases,improve the diagnosis and treatment guidelines,and develop new therapeutic methods.In this study,we have summarized various mouse spinal metastasis models and the applicable research contents.
