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皮肤渗透性预测模型在新污染物健康风险评估中的应用研究进展
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作者 祁增华 黄泽基 +2 位作者 廖永龙 陈浩佳 杨彦 《科学通报》 EI CAS CSCD 北大核心 2023年第18期2354-2365,共12页
越来越多的证据表明,皮肤暴露是新污染物进入人体的重要途径.污染物的皮肤渗透性主要由皮肤渗透系数和渗透通量两个参数来反映.借助人体和动物模型开展的体内/体外暴露实验是当前测定新污染物透皮特征的主要手段.然而,此类方法存在成本... 越来越多的证据表明,皮肤暴露是新污染物进入人体的重要途径.污染物的皮肤渗透性主要由皮肤渗透系数和渗透通量两个参数来反映.借助人体和动物模型开展的体内/体外暴露实验是当前测定新污染物透皮特征的主要手段.然而,此类方法存在成本高、耗时长、差异大以及道德伦理等诸多问题,难以及时准确地反映新污染物的皮肤暴露风险.因此,需发展皮肤渗透性预测数学模型,用于评估污染物的暴露风险和人体健康风险.本文针对风险评估中的皮肤渗透性预测数学模型,介绍皮肤基本结构及新污染物主要透皮吸收途径,概述现有皮肤渗透预测模型的基本原理及其应用,阐明渗透性预测模型在暴露风险和人体健康风险评估中的应用作用,并对数学模型开展新污染物皮肤暴露风险评估方面的研究进行展望. 展开更多
关键词 新污染物 皮肤暴露 数学模型 皮肤渗透性 风险评估
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Investigation of PM_(2.5) pollution during COVID-19 pandemic in Guangzhou,China 被引量:5
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作者 Luyao Wen Chun Yang +9 位作者 Xiaoliang Liao Yanhao Zhang Xuyang Chai Wenjun Gao Shulin Guo Yinglei Bi Suk-Ying Tsang Zhi-Feng Chen zenghua qi Zongwei Cai 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2022年第5期443-452,共10页
The COVID-19 pandemic has raised awareness about various environmental issues,includ-ing PM_(2.5) pollution.Here,PM_(2.5) pollution during the COVID-19 lockdown was traced and an-alyzed to clarify the sources and fact... The COVID-19 pandemic has raised awareness about various environmental issues,includ-ing PM_(2.5) pollution.Here,PM_(2.5) pollution during the COVID-19 lockdown was traced and an-alyzed to clarify the sources and factors influencing PM_(2.5) in Guangzhou,with an emphasis on heavy pollution.The lockdown led to large reductions in industrial and traffic emissions,which significantly reduced PM_(2.5) concentrations in Guangzhou.Interestingly,the trend of PM_(2.5) concentrations was not consistent with traffic and industrial emissions,as minimum concentrations were observed in the fourth period(3/01-3/31,22.45 μg/m^(3))of the lockdown.However,the concentrations of other gaseous pollutants,e.g.,SO_(2),NO_(2) and CO,were corre-lated with industrial and traffic emissions,and the lowest values were noticed in the sec-ond period(1/24-2/0_(3))of the lockdown.Meteorological correlation analysis revealed that the decreased PM_(2.5) concentrations during COVID-19 can be mainly attributed to decreased in-dustrial and traffic emissions rather than meteorological conditions.When meteorological factors were included in the PM_(2.5) composition and backward trajectory analyses,we found that long-distance transportation and secondary pollution offset the reduction of primary emissions in the second and third stages of the pandemic.Notably,industrial PM_(2.5) emis-sions from western,southern and southeastern Guangzhou play an important role in the formation of heavy pollution events.Our results not only verify the importance of control-ling traffic and industrial emissions,but also provide targets for further improvements in PM_(2.5) pollution. 展开更多
关键词 PM_(2.5)pollution COVID-19 pandemic PM_(2.5)composition Meteorological analysis Source appointment
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Application of a real-ambient fine particulate matter exposure system on different animal models 被引量:1
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作者 Yuanyuan Song Lifang Zhao +7 位作者 zenghua qi Yanhao Zhang Guodong Cao Ruijin Li Lin Zhu Zhu Yang Chuan Dong Zongwei Cai 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2021年第7期64-70,共7页
Simulation of fine particulate matter(PM_(2.5))exposure is essential for evaluating adverse health effects.In this work,an ambient exposure system that mimicked real atmospheric conditions was installed in Taiyuan,Chi... Simulation of fine particulate matter(PM_(2.5))exposure is essential for evaluating adverse health effects.In this work,an ambient exposure system that mimicked real atmospheric conditions was installed in Taiyuan,China to study impacts of chronic PM_(2.5) exposure on adult and aged mice as well as Sirtuin3 knockout(Sirt3 KO)mice and wild-type(WT)mice.The real-ambient exposure system eliminated the possible artificial effects caused from exposure experiments and maintained the physiochemical characteristics of PM_(2.5).The case studies indicated that aged mice exhibited apparent heart dysfunction involving in-creased heart rate and decreased blood pressure after 17-week of real-ambient PM_(2.5) exposure.Meanwhile,15-week of real-ambient PM_(2.5) exposure decreased the heart rate and amounts of associated catecholamines to induce heart failure in Sirt3 KO mice.Additionally,the increased pro-inflammatory cytokines and decreased platelet related indices suggested that inflammation occurred.The changes of biomarkers detected by targeted metabolomics confirmed metabolic disorder in WT and Sirt3 KO mice after exposed to real-ambient PM_(2.5).These results indicated that the real-ambient PM_(2.5) exposure system could evaluate the risks of certain diseases associated with air pollution and have great potential for support-ing the investigations of PM_(2.5) effects on other types of rodent models. 展开更多
关键词 Real-ambient PM_(2.5)exposure SYSTEM Adverse effects Sirt3 KO Aged mice
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重点行业场地土壤污染物的人体暴露组学与生物标志物研究 被引量:1
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作者 余应新 祁增华 +8 位作者 马盛韬 徐琳 郑晶 高艳蓬 沈先涛 蔡亚岐 张卫平 李桂英 安太成 《Science Bulletin》 SCIE EI CSCD 2021年第17期1705-1708,M0003,共5页
Rapid economic development and industrialization have left many risk sites around the world with significant or potential soil contamination due to industrial production or the shutdown or relocation of industrial fac... Rapid economic development and industrialization have left many risk sites around the world with significant or potential soil contamination due to industrial production or the shutdown or relocation of industrial facilities.Soil pollutants pose significant threats to human health,especially at sites used by the chemical,mining,and metalworking industries,among others[1]. 展开更多
关键词 人体暴露 SHUTDOWN MINING
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