Objective To evaluate the prevalence,awareness,treatment and control rate of hypertension among elder population in China.Methods Data form a cross-sectional stratified multistage random sampling survey conducted from...Objective To evaluate the prevalence,awareness,treatment and control rate of hypertension among elder population in China.Methods Data form a cross-sectional stratified multistage random sampling survey conducted from 2012 to 2015 were used to analyzed.Finally,a total of 134,397 participants aged≥60 years were enrolled in our study.Hypertension was defined as systolic BP≥140 mmHg,and/or diastolic BP≥90 mmHg,and/or use of antihypertensive medicine within 2 weeks.Among participants with hypertension,control rate of hypertension was defined as the participant presenting as hypertensive,but with a systolic BP measure less than 140 mm Hg and diastolic BP measure less than 90 mm Hg.展开更多
Objective To investigate the prevalence of hypertension overweight/obesity and the combined effect on the incidence of cardiovascular disease(CVD).Methods The study population(aged from 35 to 64)were selected from 9 r...Objective To investigate the prevalence of hypertension overweight/obesity and the combined effect on the incidence of cardiovascular disease(CVD).Methods The study population(aged from 35 to 64)were selected from 9 regions of China by cluster sampling method.The baseline was conducted in 2010,and the follow-up survey was done in 2017.Participants with 24≤BMI28 kg/m^2 was defined as overweight,BMI≥28 kg/m^2 was defined as obesity.展开更多
Objective To evaluate the effect of a workplace-based comprehensive intervention strategy on the improvement of blood pressure (BP) control.Methods A cluster controlled trail, with workplaces (clusters)assigned to eit...Objective To evaluate the effect of a workplace-based comprehensive intervention strategy on the improvement of blood pressure (BP) control.Methods A cluster controlled trail, with workplaces (clusters)assigned to either the intervention or control group. Totally, 30 statedowned enterprises across China were included, among which 20were allocated to the intervention group and 10 to the control group.展开更多
Objective To determine whether a workplace-based multicomponent intervention strategy could improve BP control among Chinese working population.Methods A cluster-controlled trail,with workplaces assigned to either the...Objective To determine whether a workplace-based multicomponent intervention strategy could improve BP control among Chinese working population.Methods A cluster-controlled trail,with workplaces assigned to either the intervention or control group.60 workplaces across 20 urban regions of China were selected.4,548 hypertensive employees aged 18-60 years were assigned intervention(n=3,470)or control(n=1,078),of whom 4,205(92.5%;intervention,n=3,209;control,n=996)were included in this analysis.展开更多
Mitochondrial toxicity induced by therapeutic drugs is a major contributor for cardiotoxicity,posing a serious threat to pharmaceutical industries and patients’lives.However,mitochondrial toxicity testing is not inco...Mitochondrial toxicity induced by therapeutic drugs is a major contributor for cardiotoxicity,posing a serious threat to pharmaceutical industries and patients’lives.However,mitochondrial toxicity testing is not incorporated into routine cardiac safety screening procedures.To accurately model native human cardiomyocytes,we comprehensively evaluated mitochondrial responses of adult human primary cardiomyocytes(h PCMs)to a nucleoside analog,remdesivir(RDV).Comparison of their response to human pluripotent stem cell-derived cardiomyocytes revealed that the latter utilized a mitophagy-based mitochondrial recovery response that was absent in h PCMs.Accordingly,action potential duration was elongated in h PCMs,reflecting clinical incidences of RDV-induced QT prolongation.In a screen for mitochondrial protectants,we identified mitochondrial ROS as a primary mediator of RDV-induced cardiotoxicity.Our study demonstrates the utility of h PCMs in the detection of clinically relevant cardiac toxicities,and offers a framework for h PCM-based high-throughput screening of cardioprotective agents.展开更多
The Chinese edition of the Annual Report on Cardiovascular Health and Diseases in China 2022 has been published.[1] We present herein an interpretation of this report.
Recent decades have seen the remarkable development of China in medical accessibility and quality index,and the application of a number of new advanced cardiovascular technologies benefits more patients.However,accord...Recent decades have seen the remarkable development of China in medical accessibility and quality index,and the application of a number of new advanced cardiovascular technologies benefits more patients.However,according to the Annual Report on Cardiovascular Health and Diseases in China published in this article,which was organized and summarized by National Center for Cardiovascular Diseases,there is still a huge population living with risk factors of cardiovascular diseases(CVD),and the morbidity and mortality of CVD are increasing.It is estimated that there are around 330 million patients suffering from CVD currently,including 245 million of hypertension,13 million of stroke,45.3 million of peripheral artery disease,11.39 million of coronary heart disease(CHD),8.9 million of heart failure,5 million of pulmonary heart disease,4.87 million of atrial fibrillation,2.5 million of rheumatic heart disease,and 2 million of congenital heart disease.Tobacco use,diet and nutrition factors,physical activity,overweight and obesity,and psychological factors are what affect cardiovascular health,while hypertension,dyslipidemia,diabetes,chronic kidney disease,metabolic syndrome,and air pollution are the risk factors for CVD.In this article,in addition to risk factors for CVD,we also report the epidemiological trends of CVD,including CHD,cerebrovascular disease,arrhythmias,valvular heart disease,congenital heart disease,cardiomyopathy,heart failure,pulmonary vascular disease and venous thromboembolism,and aortic and peripheral artery diseases,as well as the basic research and medical device development in CVD.In a word,China has entered a new stage of transforming from high-speed development focusing on scale growth to high-quality development emphasizing on strategic and key technological development to curb the trend of increasing incidence and mortality of CVD.展开更多
The Chinese edition of the Annual Report on Cardiovascular Health and Diseases in China 2021 has been published.[1] We present herein an interpretation of this report.
The World Health Organization(WHO)prioritizes pneumococcal disease as a vaccine-preventable disease and recommends the inclusion of pneumococcal conjugate vaccines(PCV)in national immunization programs worldwide.Howev...The World Health Organization(WHO)prioritizes pneumococcal disease as a vaccine-preventable disease and recommends the inclusion of pneumococcal conjugate vaccines(PCV)in national immunization programs worldwide.However,PCV is not included in the National Immunization Program in China and has low vaccination coverage due to its high cost.To address this,Weifang City implemented an innovative strategy for a 13-valent PCV(PCV13)on June 1,2021.This strategy aimed to provide one dose of PCV13 free of charge for children aged 6 months to 2 years in registered households and to adopt a commercial insurance model with one dose of PCV13 free of charge in 2023 for children over 2 years old.The Health Commission of Weifang and other departments conducted a comprehensive investigation and considered various factors,such as vaccine efectiveness,safety,accessibility,vaccine price,and immunization schedules,for eligible children(under 5 years old).Stakeholder opinions were also solicited before implementing the policy.The Commission negotiated with various vaccine manufacturers to maximize its negotiating power and reduce vaccine prices.The implementation plan was introduced under the Healthy Weifang Strategy.Following the implementation of this strategy,the full course of vaccination coverage increased signifcantly from 0.67 to 6.59%.However,vaccination coverage is still lower than that in developed countries.Weifang’s PCV13 vaccination innovative strategy is the frst of its kind in Chinese mainland and is an active pilot of non-immunization program vaccination strategies.To further promote PCV13 vaccination,Weifang City should continue to implement this strategy and explore appropriate fnancing channels.Regions with higher levels of economic development can innovate the implementation of vaccine programs,broaden fnancing channels,improve accessibility to vaccination services,and advocate for more localities to incorporate PCV13 into locally expanded immunization programs or people-benefting projects.A monitoring and evaluation system should also be established to evaluate implementation efects.展开更多
Aerosol optical depth （AOD） is a common indicator applied in monitoring aerosols in the atmosphere. The hilly landscape and rapid economic growth of the megacity Chongqing have facilitated increased aerosol concentr...Aerosol optical depth （AOD） is a common indicator applied in monitoring aerosols in the atmosphere. The hilly landscape and rapid economic growth of the megacity Chongqing have facilitated increased aerosol concentration, and it is meaningful to accurately retrieve AOD over Chongqing. The HJ-1A/B satellite of China carries a sensor/camera called the Charge Coupled Device （CCD）, the spatial resolution of which meets the requirement for re- trieving high resolution AOD. In this paper, analysis of the AOD retrievals from different methods using the H J-1 satellite data revealed the most suitable algorithm. Through comparison with the AOD product of Moderate Resolu- tion Imaging Spectroradiometer （MODIS）, the AOD retrieval results using enhanced vegetation index （EVI） to estim- ate dark pixels showed the highest correlation. The continental aerosol model was used to build a lookup table that was able to facilitate a good AOD retrieval for both city and rural areas. Finally, the algorithm that combined dark pixels, buffer areas, and the deep blue algorithm was found to be most suitable for AOD retrieval. The AOD retrieval results based on the HJ-1 data were consistent with MODIS products, and our algorithm yields reasonable results in most cases. The results were also compared with ground-based PMl0 measurements synchronized with the overpass time of the HJ-1 satellite, and high correlation was found. The findings are relevant to other Chinese satellite data used for retrieving AOD on the same channels.展开更多
The Chinese edition of the Annual Report on Cardiovascular Health and Diseases in China 2020 has been published.[1]We present herein an interpretation of this report.Factors influencing cardiovascular health Tobacco u...The Chinese edition of the Annual Report on Cardiovascular Health and Diseases in China 2020 has been published.[1]We present herein an interpretation of this report.Factors influencing cardiovascular health Tobacco use About 1.9 million avoidable deaths from coronary heart disease(CHD)per year(approximately one-fifth of all CHD deaths globally)are attributable to tobacco use and exposure to secondhand smoke(SHS).An estimated 382,000 people died of CHD attributable to SHS exposure,representing 4.3%of all deaths from CHD.展开更多
The Chinese edition of Annual Report on Cardiovascular Health and Diseases in China 2019 have been published[1],and we present herein an interpretation of the report.Influencing factors on cardiovascular health Tobacc...The Chinese edition of Annual Report on Cardiovascular Health and Diseases in China 2019 have been published[1],and we present herein an interpretation of the report.Influencing factors on cardiovascular health Tobacco use The smoking prevalence among Chinese residents has shown a downward trend.According to the Chinese Adult Tobacco Survey in 2018,the current smoking prevalence among Chinese residents≥15years of age was 26.6%,which was higher in rural areas(28.9%)than in urban areas(25.1%),and the daily consumption by each smoker was 16.0 cigarettes on average.展开更多
文摘Objective To evaluate the prevalence,awareness,treatment and control rate of hypertension among elder population in China.Methods Data form a cross-sectional stratified multistage random sampling survey conducted from 2012 to 2015 were used to analyzed.Finally,a total of 134,397 participants aged≥60 years were enrolled in our study.Hypertension was defined as systolic BP≥140 mmHg,and/or diastolic BP≥90 mmHg,and/or use of antihypertensive medicine within 2 weeks.Among participants with hypertension,control rate of hypertension was defined as the participant presenting as hypertensive,but with a systolic BP measure less than 140 mm Hg and diastolic BP measure less than 90 mm Hg.
文摘Objective To investigate the prevalence of hypertension overweight/obesity and the combined effect on the incidence of cardiovascular disease(CVD).Methods The study population(aged from 35 to 64)were selected from 9 regions of China by cluster sampling method.The baseline was conducted in 2010,and the follow-up survey was done in 2017.Participants with 24≤BMI28 kg/m^2 was defined as overweight,BMI≥28 kg/m^2 was defined as obesity.
文摘Objective To evaluate the effect of a workplace-based comprehensive intervention strategy on the improvement of blood pressure (BP) control.Methods A cluster controlled trail, with workplaces (clusters)assigned to either the intervention or control group. Totally, 30 statedowned enterprises across China were included, among which 20were allocated to the intervention group and 10 to the control group.
文摘Objective To determine whether a workplace-based multicomponent intervention strategy could improve BP control among Chinese working population.Methods A cluster-controlled trail,with workplaces assigned to either the intervention or control group.60 workplaces across 20 urban regions of China were selected.4,548 hypertensive employees aged 18-60 years were assigned intervention(n=3,470)or control(n=1,078),of whom 4,205(92.5%;intervention,n=3,209;control,n=996)were included in this analysis.
基金supported by the CAMS Innovation Fund for Medical Sciences(CIFMS)(2021-1-I2M-006,2023-I2M-1-003,2022-I2M-2-001,2021-1-I2M-019)the National Natural Science Foundation of China(82070287,82088101 and 82025004)the National Key Research and Development Program of China(2022YFA1104500)。
文摘Mitochondrial toxicity induced by therapeutic drugs is a major contributor for cardiotoxicity,posing a serious threat to pharmaceutical industries and patients’lives.However,mitochondrial toxicity testing is not incorporated into routine cardiac safety screening procedures.To accurately model native human cardiomyocytes,we comprehensively evaluated mitochondrial responses of adult human primary cardiomyocytes(h PCMs)to a nucleoside analog,remdesivir(RDV).Comparison of their response to human pluripotent stem cell-derived cardiomyocytes revealed that the latter utilized a mitophagy-based mitochondrial recovery response that was absent in h PCMs.Accordingly,action potential duration was elongated in h PCMs,reflecting clinical incidences of RDV-induced QT prolongation.In a screen for mitochondrial protectants,we identified mitochondrial ROS as a primary mediator of RDV-induced cardiotoxicity.Our study demonstrates the utility of h PCMs in the detection of clinically relevant cardiac toxicities,and offers a framework for h PCM-based high-throughput screening of cardioprotective agents.
文摘The Chinese edition of the Annual Report on Cardiovascular Health and Diseases in China 2022 has been published.[1] We present herein an interpretation of this report.
文摘Recent decades have seen the remarkable development of China in medical accessibility and quality index,and the application of a number of new advanced cardiovascular technologies benefits more patients.However,according to the Annual Report on Cardiovascular Health and Diseases in China published in this article,which was organized and summarized by National Center for Cardiovascular Diseases,there is still a huge population living with risk factors of cardiovascular diseases(CVD),and the morbidity and mortality of CVD are increasing.It is estimated that there are around 330 million patients suffering from CVD currently,including 245 million of hypertension,13 million of stroke,45.3 million of peripheral artery disease,11.39 million of coronary heart disease(CHD),8.9 million of heart failure,5 million of pulmonary heart disease,4.87 million of atrial fibrillation,2.5 million of rheumatic heart disease,and 2 million of congenital heart disease.Tobacco use,diet and nutrition factors,physical activity,overweight and obesity,and psychological factors are what affect cardiovascular health,while hypertension,dyslipidemia,diabetes,chronic kidney disease,metabolic syndrome,and air pollution are the risk factors for CVD.In this article,in addition to risk factors for CVD,we also report the epidemiological trends of CVD,including CHD,cerebrovascular disease,arrhythmias,valvular heart disease,congenital heart disease,cardiomyopathy,heart failure,pulmonary vascular disease and venous thromboembolism,and aortic and peripheral artery diseases,as well as the basic research and medical device development in CVD.In a word,China has entered a new stage of transforming from high-speed development focusing on scale growth to high-quality development emphasizing on strategic and key technological development to curb the trend of increasing incidence and mortality of CVD.
文摘The Chinese edition of the Annual Report on Cardiovascular Health and Diseases in China 2021 has been published.[1] We present herein an interpretation of this report.
基金supported by Bill and Melinda Gates Foundation(OPP1216666)Natural Science Foundation of Shandong Province(ZR2022MG032)+1 种基金Key R&D Program of Shandong Province,China(2023RKY07003)the research“Innovation Lab of Vaccine Delivery Research,”supported by the Bill&Melinda Gates Foundation(INV034554).
文摘The World Health Organization(WHO)prioritizes pneumococcal disease as a vaccine-preventable disease and recommends the inclusion of pneumococcal conjugate vaccines(PCV)in national immunization programs worldwide.However,PCV is not included in the National Immunization Program in China and has low vaccination coverage due to its high cost.To address this,Weifang City implemented an innovative strategy for a 13-valent PCV(PCV13)on June 1,2021.This strategy aimed to provide one dose of PCV13 free of charge for children aged 6 months to 2 years in registered households and to adopt a commercial insurance model with one dose of PCV13 free of charge in 2023 for children over 2 years old.The Health Commission of Weifang and other departments conducted a comprehensive investigation and considered various factors,such as vaccine efectiveness,safety,accessibility,vaccine price,and immunization schedules,for eligible children(under 5 years old).Stakeholder opinions were also solicited before implementing the policy.The Commission negotiated with various vaccine manufacturers to maximize its negotiating power and reduce vaccine prices.The implementation plan was introduced under the Healthy Weifang Strategy.Following the implementation of this strategy,the full course of vaccination coverage increased signifcantly from 0.67 to 6.59%.However,vaccination coverage is still lower than that in developed countries.Weifang’s PCV13 vaccination innovative strategy is the frst of its kind in Chinese mainland and is an active pilot of non-immunization program vaccination strategies.To further promote PCV13 vaccination,Weifang City should continue to implement this strategy and explore appropriate fnancing channels.Regions with higher levels of economic development can innovate the implementation of vaccine programs,broaden fnancing channels,improve accessibility to vaccination services,and advocate for more localities to incorporate PCV13 into locally expanded immunization programs or people-benefting projects.A monitoring and evaluation system should also be established to evaluate implementation efects.
基金Supported by the National Natural Science Foundation of China(41631180 and 41471305)Sichuan Youth Science Fund(2015JQ0037)+2 种基金Chongqing Meteorological Bureau Open Fund(kfjj-201402)China Meteorological Administration Special Fund for Forecasting(CMAHX20160406)Sichuan Province Department of Education Innovation Team Fund(16TD0024)
文摘Aerosol optical depth （AOD） is a common indicator applied in monitoring aerosols in the atmosphere. The hilly landscape and rapid economic growth of the megacity Chongqing have facilitated increased aerosol concentration, and it is meaningful to accurately retrieve AOD over Chongqing. The HJ-1A/B satellite of China carries a sensor/camera called the Charge Coupled Device （CCD）, the spatial resolution of which meets the requirement for re- trieving high resolution AOD. In this paper, analysis of the AOD retrievals from different methods using the H J-1 satellite data revealed the most suitable algorithm. Through comparison with the AOD product of Moderate Resolu- tion Imaging Spectroradiometer （MODIS）, the AOD retrieval results using enhanced vegetation index （EVI） to estim- ate dark pixels showed the highest correlation. The continental aerosol model was used to build a lookup table that was able to facilitate a good AOD retrieval for both city and rural areas. Finally, the algorithm that combined dark pixels, buffer areas, and the deep blue algorithm was found to be most suitable for AOD retrieval. The AOD retrieval results based on the HJ-1 data were consistent with MODIS products, and our algorithm yields reasonable results in most cases. The results were also compared with ground-based PMl0 measurements synchronized with the overpass time of the HJ-1 satellite, and high correlation was found. The findings are relevant to other Chinese satellite data used for retrieving AOD on the same channels.
文摘The Chinese edition of the Annual Report on Cardiovascular Health and Diseases in China 2020 has been published.[1]We present herein an interpretation of this report.Factors influencing cardiovascular health Tobacco use About 1.9 million avoidable deaths from coronary heart disease(CHD)per year(approximately one-fifth of all CHD deaths globally)are attributable to tobacco use and exposure to secondhand smoke(SHS).An estimated 382,000 people died of CHD attributable to SHS exposure,representing 4.3%of all deaths from CHD.
文摘The Chinese edition of Annual Report on Cardiovascular Health and Diseases in China 2019 have been published[1],and we present herein an interpretation of the report.Influencing factors on cardiovascular health Tobacco use The smoking prevalence among Chinese residents has shown a downward trend.According to the Chinese Adult Tobacco Survey in 2018,the current smoking prevalence among Chinese residents≥15years of age was 26.6%,which was higher in rural areas(28.9%)than in urban areas(25.1%),and the daily consumption by each smoker was 16.0 cigarettes on average.
