We describe an iridium-catalyzed ortho-selective C–H borylation of unprotected anilines.The employing strongσ-donating cyclometalated mesoionic carbene as C^C bidentate ligand is crucial for the high ortho-selectivi...We describe an iridium-catalyzed ortho-selective C–H borylation of unprotected anilines.The employing strongσ-donating cyclometalated mesoionic carbene as C^C bidentate ligand is crucial for the high ortho-selectivity.Computational studies support outer-sphere X–H⋅⋅⋅O_(boryl) hydrogen bond interactions,which are strengthened by bidentate C^C ligand introduction.The method shows broad substrate scope and high functional group tolerance.展开更多
基金This work was supported by the National Natural Science Foundation of China(Nos.22171284 and 21602249)the Fundamental Research Funds for the Central Universities,the Research Funds of Renmin University of China(No.20XNLG20)the Public Computing Cloud Platform,Renmin University of China.
文摘We describe an iridium-catalyzed ortho-selective C–H borylation of unprotected anilines.The employing strongσ-donating cyclometalated mesoionic carbene as C^C bidentate ligand is crucial for the high ortho-selectivity.Computational studies support outer-sphere X–H⋅⋅⋅O_(boryl) hydrogen bond interactions,which are strengthened by bidentate C^C ligand introduction.The method shows broad substrate scope and high functional group tolerance.
