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果胶@壳聚糖复合凝胶微球的制备及释药性能 被引量:3
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作者 李佳颖 孙琪琪 +5 位作者 樊曦 蔡文睿 潘杨 王增增 何斌 李赛 《高分子材料科学与工程》 EI CAS CSCD 北大核心 2023年第6期42-53,共12页
文中以天然多糖果胶和壳聚糖为原料,采用乳化交联的方法制备了果胶酸锌微球,再通过自组装壳聚糖层并用柠檬酸钠固化,得到了核壳结构的凝胶微球,将药物奥沙拉嗪封装在凝胶微球中,考察了其药物缓释性能。通过红外光谱、扫描电镜、能谱分... 文中以天然多糖果胶和壳聚糖为原料,采用乳化交联的方法制备了果胶酸锌微球,再通过自组装壳聚糖层并用柠檬酸钠固化,得到了核壳结构的凝胶微球,将药物奥沙拉嗪封装在凝胶微球中,考察了其药物缓释性能。通过红外光谱、扫描电镜、能谱分析和荧光显微镜对微球形貌和核壳结构进行了表征。通过单因素变量法对凝胶微球的制备进行了优化,并对微球的药物负载性能及在模拟结肠环境中的释药行为进行了研究。结果表明,果胶@壳聚糖载药微球的最高载药量和包封率分别为29.4%和37.3%,果胶@壳聚糖复合载药微球在pH=7.4的模拟结肠液中,前12 h内的释放量仅为35.29%,72 h后奥沙拉嗪的释放量达到了89.90%,而纯果胶载药微球前12 h的释放量就已经高达78.65%,体现了壳聚糖包封层在药物缓释中的重要性。锌离子在果胶@壳聚糖复合微球和果胶微球中的释放趋势与奥沙拉嗪一致,相比于果胶微球,果胶@壳聚糖复合微球具备良好的缓释性能,可用于治疗结肠炎症疾病。 展开更多
关键词 果胶 壳聚糖 凝胶微球 核壳结构 药物缓释
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Self-adaptive rolling motion for snake robots in unstructured environments based on torque control
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作者 Shihao Ma Fatao Qin +5 位作者 Shufan Chen Longchuan Li Jianming wang zengzeng wang Shuai Li Xuan Xiao 《Biomimetic Intelligence & Robotics》 EI 2023年第3期59-66,共8页
Snake robots have great potential for exploring and operating in challenging unstructured environments,such as rubble,caves,and narrow pipelines.However,due to the complexity and unpredictability of unstructured envir... Snake robots have great potential for exploring and operating in challenging unstructured environments,such as rubble,caves,and narrow pipelines.However,due to the complexity and unpredictability of unstructured environments,designing a controller that can achieve adaptive motion is crucial.This paper proposes a self-adaptive torque-based rolling controller for snake robots,enabling compliant motion in unstructured environments.First,a controller is designed to modify the torque of each motor by focusing on the different motion states of the rolling gait.Second,an experimental platform is established for snake robots to verify the effectiveness of the controller.Finally,a series of rolling experiments are conducted using the torque-based rolling controller.In conclusion,the self-adaptive torque-based rolling controller enhances snake robot adaptability and mobility. 展开更多
关键词 Snake robot Torque-based control Self-adaptive rolling gait Unstructured environments
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