To the Editor,Rheumatoid arthritis(RA)synovitis is characterized by synovial inflammation,characterized by synovial proliferation,neovascularization,and leukocyte infiltration into the joint space,1 leading to irrever...To the Editor,Rheumatoid arthritis(RA)synovitis is characterized by synovial inflammation,characterized by synovial proliferation,neovascularization,and leukocyte infiltration into the joint space,1 leading to irreversible cartilage and bone damage.2 This synovial inflammation stimulates the formation of pannus,which is an invasive tumor-like mass,ultimately contributing to the pathogenesis of RA.RA shares several similarities with cancer,including joint pain,swelling,and stiffness,which are accompanied by hypoxia in the synovial tissue and tumor environment.3 Spalt-like transcription factor 4(SALL4)plays an essential role in the occurrence and development of tumors.4 However,SALL4 expression in synovial tissue of RA is yet to be investigated.This study aimed to investigate SALL4 expression in synovial tissue derived from patients with RA,using immunohistochemical techniques.展开更多
基金Shanxi Provincial Department of Science and Technology(Grant/Award Number:201803D421072).
文摘To the Editor,Rheumatoid arthritis(RA)synovitis is characterized by synovial inflammation,characterized by synovial proliferation,neovascularization,and leukocyte infiltration into the joint space,1 leading to irreversible cartilage and bone damage.2 This synovial inflammation stimulates the formation of pannus,which is an invasive tumor-like mass,ultimately contributing to the pathogenesis of RA.RA shares several similarities with cancer,including joint pain,swelling,and stiffness,which are accompanied by hypoxia in the synovial tissue and tumor environment.3 Spalt-like transcription factor 4(SALL4)plays an essential role in the occurrence and development of tumors.4 However,SALL4 expression in synovial tissue of RA is yet to be investigated.This study aimed to investigate SALL4 expression in synovial tissue derived from patients with RA,using immunohistochemical techniques.
