Polyphenols and pectin enriched golden kiwifruit (Actinidia chinensis) alleviates high fructose-induced glucolipid disorders and hepatic oxidative damage in rats:in association with improvement of fatty acids metabolism

This study aimed to investigate the protective effects of fleshes from two Actinidia chinensis(ACF), pericarps from two A. chinensis(ACP), and fleshes with pericarps from two A. chinensis(ACFP)on high fructose(HF)-instigated dyslipidemia, hepatic steatosis, oxidative stress, insulin resistance, and fatty acid metabolism disorders in rats. In general, the above abnormalities were improved after 10 weeks intervention of ACF, ACP, and ACFP. Especially, ACFP considerably ameliorated HF-induced abnormal changes in body weight gain, serum TC, TG, LDL-C and HDL-C levels, as well as serum and hepatic SFAs, MUFAs and PUFAs contents. ACFP also alleviated HF-induced hyperglycemia and hyperinsulinemia, stabilized HF-caused increase in hepatic MDA and serum ALT, AST levels, and restored HF-declined hepatic T-SOD and GSH-Px activities. Besides, histopathology of the liver further endorsed the protective effects of ACFP on hepatocellular injury. Moreover, ACFP increased HF-dropped acetic, propionic and butyric acid levels. Overall, ACFP employs more efficacious protective effects against HF-induced metabolic disorders and liver damage than ACF and ACP. This study delivers a scientific foundation for developing kiwifruit(counting peel)-based dietary supplements for those with glucolipid-metabolic disorders and liver damage.

Hydrological response under CMIP6 climate projection in Astore River Basin,Pakistan

Climate change strongly influences the available water resources in a watershed due to direct linkage of atmospheric driving forces and changes in watershed hydrological processes.Understanding how these climatic changes affect watershed hydrology is essential for human society and environmental processes.Coupled Model Intercomparison Project phase 6(CMIP6)dataset of three GCM's(BCC-CSM2-MR,INM-CM5-0,and MPIESM1-2-HR)with resolution of 100 km has been analyzed to examine the projected changes in temperature and precipitation over the Astore catchment during 2020-2070.Bias correction method was used to reduce errors.In this study,statistical significance of trends was performed by using the Man-Kendall test.Sen's estimator determined the magnitude of the trend on both seasonal and annual scales at Rama Rattu and Astore stations.MPI-ESM1-2-HR showed better results with coefficient of determination(COD)ranging from 0.70-0.74 for precipitation and 0.90-0.92 for maximum and minimum temperature at Astore,Rama,and Rattu followed by INM-CM5-0 and BCC-CSM2-MR.University of British Columbia Watershed model was used to attain the future hydrological series and to analyze the hydrological response of Astore River Basin to climate change.Results revealed that by the end of the 2070s,average annual precipitation is projected to increase up to 26.55%under the SSP1-2.6,6.91%under SSP2-4.5,and decrease up to 21.62%under the SSP5-8.5.Precipitation also showed considerable variability during summer and winter.The projected temperature showed an increasing trend that may cause melting of glaciers.The projected increase in temperature ranges from-0.66℃ to 0.50℃,0.9℃ to 1.5℃ and 1.18℃ to 2℃ under the scenarios of SSP1-2.6,SSP2-4.5 and SSP5-8.5,respectively.Simulated streamflows presented a slight increase by all scenarios.Maximum streamflow was generated under SSP5-8.5 followed by SSP2-4.5 and SSP1-2.6.The snowmelt and groundwater contributions to streamflow have decreased whereas rainfall and glacier melt components have increased on the other hand.The projected streamflows(2020-2070)compared to the control period(1990-2014)showed a reduction of 3%-11%,2%-9%,and 1%-7%by SSP1-2.6,SSP2-4.5,and SSP5-8.5,respectively.The results revealed detailed insights into the performance of three GCMs,which can serve as a blueprint for regional policymaking and be expanded upon to establish adaption measures.