Due to its difficulty and complexity,the cleavage and subsequent functionalization of the C(sp^(3))-C(sp^(3))single bond has received less attention than the C-C bond formation reactions that have been extensively stu...Due to its difficulty and complexity,the cleavage and subsequent functionalization of the C(sp^(3))-C(sp^(3))single bond has received less attention than the C-C bond formation reactions that have been extensively studied.Herein,by utilizing Cu/g-C_(3)N_(4)nanometric semiconductor as a recyclable photocatalyst,an aerobic oxidative C-C bond cleavage of aldehydes was developed with the promotion of amines under visible light irradiation.Based on the reaction,phenylacetaldehyde was selected as a highly efficient formylation reagent for amines.Under blue light irradiation,good to excellent yields of formamides were achieved for various amines in 1 atm oxygen atmosphere at room temperature.This methodology offers a practical,neutral and gentle alternative to the preparation of formamides.展开更多
基金the financial support from the National Natural Science Foundation of China(Nos.21772091,21472092 to X.Yao)funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions。
文摘Due to its difficulty and complexity,the cleavage and subsequent functionalization of the C(sp^(3))-C(sp^(3))single bond has received less attention than the C-C bond formation reactions that have been extensively studied.Herein,by utilizing Cu/g-C_(3)N_(4)nanometric semiconductor as a recyclable photocatalyst,an aerobic oxidative C-C bond cleavage of aldehydes was developed with the promotion of amines under visible light irradiation.Based on the reaction,phenylacetaldehyde was selected as a highly efficient formylation reagent for amines.Under blue light irradiation,good to excellent yields of formamides were achieved for various amines in 1 atm oxygen atmosphere at room temperature.This methodology offers a practical,neutral and gentle alternative to the preparation of formamides.
